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Chemical Structure| 501-30-4 Chemical Structure| 501-30-4
Chemical Structure| 501-30-4

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Kojic acid is a chelation agent produced by several species of fungi.

Synonyms: NSC 1942

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Product Details of Kojic acid

CAS No. :501-30-4
Formula : C6H6O4
M.W : 142.11
SMILES Code : O=C1C=C(CO)OC=C1O
Synonyms :
NSC 1942
MDL No. :MFCD00006580
InChI Key :BEJNERDRQOWKJM-UHFFFAOYSA-N
Pubchem ID :3840

Safety of Kojic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H351
Precautionary Statements:P201-P280-P305+P351+P338-P405

Application In Synthesis of Kojic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 501-30-4 ]

[ 501-30-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 501-30-4 ]
  • [ 62-53-3 ]
  • [ 70033-61-3 ]
YieldReaction ConditionsOperation in experiment
49% 5-Hydroxy-2-hydroxymethyl-1-phenyl-pyridin-4-one (214) (Looker, J. H.; Cliffton, M. D. Convenient preparative methods for N-aryl-γ-pyridones from γ-pyrones. J. Hetero. Chem. 1986, 23, 5). To a suspension of kojic acid (1.421 g, 10.00 mmol) in diluted hydrochloric acid (0.52 mL of concentrated hydrochloric acid diluted with 25 mL of water) was added aniline (1.40 mL, 15.4 mmol). The resulting mixture was heated under reflux for 20 h. The mixture, while warn (60 C.), was washed with dichloromethane two times and the organic phase was discarded. The aqueous phase was neutralized with solid sodium carbonate, upon which much off-white precipitate appeared. The mixture stood in a hood overnight. The crude product was isolated by filtration and purified by recrystallization with methanol to give a pale solid (1.064 g, 49%). Mp: 236-238 C. (lit.85 237-240 C.). 1H NMR (d6-DMSO): δ 4.20 (2H, s), 6.47 (1H, s), 7.35 (1H, s), 7.5-7.6 (5H, m). 13C NMR (d6-DMSO): δ 70.9, 102.5, 114.8, 118.2, 118.9, 130.5, 138.7, 146.7, 165.3, 179.5.
 

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