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Quality Control of H-Phe(3,4-DiF)-OH Purity: 97% SDS Specification

COA

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NMR

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CNMR

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HPLC

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Product Details of H-Phe(3,4-DiF)-OH

CAS No. :	31105-90-5
Formula :	C₉H₉F₂NO₂
M.W :	201.17
SMILES Code :	O=C(O)[C@@H](N)CC1=CC=C(F)C(F)=C1
Synonyms :	3,4-Difluoro-L-phenylalanine
MDL No. :	MFCD01075125
InChI Key :	PRAWYXDDKCVZTL-QMMMGPOBSA-N
Pubchem ID :	716295

Safety of H-Phe(3,4-DiF)-OH

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of H-Phe(3,4-DiF)-OH

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 31105-90-5 ]

[ 31105-90-5 ] Synthesis Path-Downstream 1~19

1
[ 24424-99-5 ]
[ 31105-90-5 ]
[ 198474-90-7 ]

References: [1]Tetrahedron Letters,2000,vol. 41,p. 923 - 927.

2
[ 266360-51-4 ]
[ 31105-90-5 ]
[ 266360-57-0 ]

References: [1]Tetrahedron Letters,2000,vol. 41,p. 923 - 927.

3
[ 67-56-1 ]
[ 31105-90-5 ]
methyl (2S)-2-amino-3-(3,4-difluorophenyl)propanoate hydrochloride [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2002,vol. 12,p. 637 - 640.

4
[ 31105-90-5 ]
(S)-2-[(S)-1-(3,5-Dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-3-(3,4-difluoro-phenyl)-propionic acid [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2002,vol. 12,p. 637 - 640.

5
[ 31105-90-5 ]
(S)-2-[(S)-1-(3,5-Dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-3-(3,4-difluoro-phenyl)-propionic acid methyl ester [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2002,vol. 12,p. 637 - 640.

6
[ 15017-45-5 ]
[ 31105-90-5 ]

References: [1]Tetrahedron Letters,2000,vol. 41,p. 923 - 927.

7
[ 85118-01-0 ]
[ 31105-90-5 ]

References: [1]Tetrahedron Letters,2000,vol. 41,p. 923 - 927.

8
2-acetylamino-2-(3,4-difluoro-benzyl)-malonic acid [ No CAS ]
[ 31105-90-5 ]

References: [1]Tetrahedron Letters,2000,vol. 41,p. 923 - 927.

9
[ 31105-90-5 ]
[ 1364867-97-9 ]

Yield	Reaction Conditions	Operation in experiment
100%		(+)-3,4-difluorophenyl alanine (1.0 g, 5.0 mmol) was added in small portions to a stirring suspension of LiAlH4 (0.480 g, 12.5 mmol) in THF (30 mL) at 0 C. The resulting gray suspension was then heated at reflux for 2 h. The reaction mixture was cooled to 0 C. and then carefully quenched sequentially with water (0.5 mL), 3 N NaOH (0.5 mL), and water (1.50 mL). The resulting suspension was filtered through a fritted glass funnel. Ether (50 mL) was added to the filter cake and the suspension was heated at reflux temperature for 20 min. The suspension was filtered and was combined with the previous filtrate. The combined organics were dried over MgSO4, filtered and the solvent was removed in vacuo. 2-Amino-3-(3,4-difluoro)-phenyl-propan-1-ol was obtained as a white solid (0.500 g, 100%) which was used in the next step without further purification.

References: [1]Patent: US6727264,2004,B1 .Location in patent: Page column 66; 103.

10
[ 152152-17-5 ]
[ 31105-90-5 ]

References: [1]Catalysis science and technology,2016,vol. 6,p. 4086 - 4089.

11
[ 34036-07-2 ]
[ 31105-90-5 ]

References: [1]Tetrahedron,2016,vol. 72,p. 7256 - 7262.

12
[ 112897-97-9 ]
[ 31105-90-5 ]