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Chemical Structure| 4353-32-6 Chemical Structure| 4353-32-6
Chemical Structure| 4353-32-6

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Product Details of H-Arg(Tos)-OH

CAS No. :4353-32-6
Formula : C13H20N4O4S
M.W : 328.39
SMILES Code : N[C@@H](CCCNC(NS(=O)(C1=CC=C(C)C=C1)=O)=N)C(O)=O
MDL No. :MFCD00077167
InChI Key :SLTWQHUEZWYAOI-NSHDSACASA-N
Pubchem ID :7408233

Safety of H-Arg(Tos)-OH

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of H-Arg(Tos)-OH

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 4353-32-6 ]

[ 4353-32-6 ] Synthesis Path-Downstream   1~31

  • 2
  • [ 4353-32-6 ]
  • [ 88419-43-6 ]
  • Z(OMe)-Lys(Z)-Tyr-Arg(Tos)-OH [ No CAS ]
  • 3
  • [ 4353-32-6 ]
  • [(R)-5-[(S)-1-Azidocarbonyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-5-(4-methoxy-benzyloxycarbonylamino)-pentyl]-carbamic acid benzyl ester [ No CAS ]
  • [ 97186-06-6 ]
  • 5
  • [ 4353-32-6 ]
  • [ 75-07-0 ]
  • (Nα-Et)Arg(Tos) [ No CAS ]
  • 6
  • [ 1234-35-1 ]
  • [ 98-59-9 ]
  • [ 4353-32-6 ]
  • 7
  • [ 30761-96-7 ]
  • [ 4353-32-6 ]
  • p-Methoxybenzyloxycarbonyl-arginin-tosylat [ No CAS ]
  • 8
  • [ 53122-06-8 ]
  • [ 4353-32-6 ]
  • [ 52885-31-1 ]
  • 9
  • [ 1871-76-7 ]
  • [ 4353-32-6 ]
  • Nα-(diphenylmethylcarbonyl)-toluenesulfonyl-L-arginine [ No CAS ]
  • 10
  • [ 5854-52-4 ]
  • [ 4353-32-6 ]
  • Nα-(1-adamantyloxycarbonyl)-toluenesulfonyl-L-arginine [ No CAS ]
  • 11
  • [ 33948-19-5 ]
  • [ 4353-32-6 ]
  • Nα-(10,11-dihydroo-5H-dibenz[b.f]azepine-5-carbonyl)toluenesulfonyl-L-arginine [ No CAS ]
  • 12
  • [ 13650-38-9 ]
  • [ 4353-32-6 ]
  • 14
  • [ 4353-32-6 ]
  • H-(S)-NG-p-toluenesulfonyl-5-guanidino-2-hydroxy-pentanoic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
15% With tert.-butylnitrite; In 1,4-dioxane; water; at 20.0℃; for 1.0h;Inert atmosphere; General procedure: The Boc-protected amino acid (1 mmol) was treated with TFA (3 mL) for 15 minutes. Afterevaporation the residue was dissolved in dioxane-water (1:1, 4 mL) and the flask wasplaced in an ice bath. tert-Butylnitrite (0.13 mL, 1.1 mmol) was added and stirring wasmaintained under nitrogen at room temperature for one hour. After pouring the reactionmixture onto celite and evaporation (50 Pa, 30 C) into a dry free-floating powder,separation was performed utilizing a CombiFlash Rf (Teledyne ISCO) automated flashchromatography apparatus by means of AcOH-MeOH-EtOAc (1:9:90) on a normal phasesilica column affording the pure a-hydroxy carboxylic acid in the yield specified in Table 1.HO-His(Bom)-OH and HO-<strong>[4353-32-6]Arg(Tos)</strong>-OH were isolated by adding water (30 mL) to thereaction mixture followed by freeze drying and HPLC purification.
  • 15
  • [ 1234-35-1 ]
  • [ 4353-32-6 ]
  • 16
  • [ 98-59-9 ]
  • 1-propyloxy-ethanol-(2) [ No CAS ]
  • [ 4353-32-6 ]
  • 20
  • [ 4353-32-6 ]
  • Boc-(Nα-Et)Arg(Tos) [ No CAS ]
  • 21
  • [ 4353-32-6 ]
  • Boc-(Nα-Bzl)Arg(Tos) [ No CAS ]
  • 22
  • [ 4353-32-6 ]
  • [ 136620-31-0 ]
  • 23
  • [ 4353-32-6 ]
  • [ 136642-76-7 ]
  • 24
  • [ 4353-32-6 ]
  • [ 136620-33-2 ]
  • 25
  • [ 4353-32-6 ]
  • (2-mercaptobenzoyl)-Nα-methyl-Arg-Gly-Asp-2-mercaptoanilide cyclic disulfide [ No CAS ]
  • 26
  • [ 4353-32-6 ]
  • [ 83759-54-0 ]
  • 27
  • [ 4353-32-6 ]
  • [ 86579-32-0 ]
  • 28
  • [ 4353-32-6 ]
  • Z(OMe)-Thr-Ser-Lys(Z)-Tyr-Arg(Tos)-OH [ No CAS ]
  • 29
  • [ 4353-32-6 ]
  • H-Thr-Ser-Lys-Tyr-Arg-OH [ No CAS ]
  • 30
  • [ 4353-32-6 ]
  • [ 88419-44-7 ]
  • 31
  • [ 13836-37-8 ]
  • [ 4353-32-6 ]
YieldReaction ConditionsOperation in experiment
With trifluoroacetic acid; at 20.0℃; for 0.25h; General procedure: The Boc-protected amino acid (1 mmol) was treated with TFA (3 mL) for 15 minutes. Afterevaporation the residue was dissolved in dioxane-water (1:1, 4 mL) and the flask wasplaced in an ice bath. tert-Butylnitrite (0.13 mL, 1.1 mmol) was added and stirring wasmaintained under nitrogen at room temperature for one hour. After pouring the reactionmixture onto celite and evaporation (50 Pa, 30 C) into a dry free-floating powder,separation was performed utilizing a CombiFlash Rf (Teledyne ISCO) automated flashchromatography apparatus by means of AcOH-MeOH-EtOAc (1:9:90) on a normal phasesilica column affording the pure a-hydroxy carboxylic acid in the yield specified in Table 1.HO-His(Bom)-OH and HO-Arg(Tos)-OH were isolated by adding water (30 mL) to thereaction mixture followed by freeze drying and HPLC purification.
 

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