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Type HazMat fee for 500 gram (Estimated)
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Chemical Structure| 112811-66-2 Chemical Structure| 112811-66-2
Chemical Structure| 112811-66-2

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Product Details of Gatifloxacin Impurity 5

CAS No. :112811-66-2
Formula : C8H4ClF3O2
M.W : 224.56
SMILES Code : O=C(Cl)C1=CC(F)=C(F)C(OC)=C1F
MDL No. :MFCD02682012
InChI Key :JVQSZTJTWSUJCR-UHFFFAOYSA-N
Pubchem ID :2775281

Safety of Gatifloxacin Impurity 5

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:1760
Packing Group:

Application In Synthesis of Gatifloxacin Impurity 5

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 112811-66-2 ]

[ 112811-66-2 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 16173-58-3 ]
  • [ 765-30-0 ]
  • [ 112811-66-2 ]
  • [ 112811-71-9 ]
YieldReaction ConditionsOperation in experiment
63.16% Put 15.0g of N, N-dimethylaminoacrylate in a reaction flask,Then put 11.11g triethylamine and 100ml ethyl acetate,Stir and mix and heat to 60 , take 2,4,5-trifluoro-3 methoxybenzoyl chloride 22.5g,Dissolve it in 100 ml of ethyl acetate, and then slowly drip the dissolved matter into the reaction flask. After 1 hour of dripping, increase the temperature to 80 C.Stir reaction for 2h,After cooling to room temperature, 6.6 g of acetic acid was added for acidification.After 5.7 g of cyclopropylamine was added dropwise, stirring was continued for 0.5 hours, and 120 ml of distilled water was added.Transfer the mixed liquid to a separatory funnel and separate the upper water layer,Wash once with distilled water, and then extract the aqueous layer with 100ml of ethyl acetate,Combine the organic layer into the reaction flask, then add 27.6g of potassium hydroxide,Adjust the temperature to 140 C to remove water, and cool after 7 hours.Ethyl acetate was distilled off under reduced pressure to precipitate a brownish yellow solid,Wash three times with water and isopropanol,Dried under vacuum to obtain 21.4 g of white solid powder,The yield was 63.16%.
 

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