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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
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Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
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Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 75932-02-4 |
Formula : | C36H34N2O6 |
M.W : | 590.67 |
SMILES Code : | OC(=O)[C@@H](CCCCNC(=O)OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)NC(=O)OCC1C2=C(C=CC=C2)C2=C1C=CC=C2 |
MDL No. : | MFCD00270743 |
InChI Key : | BMJRTKDVFXYEFS-MGBGTMOVSA-N |
Pubchem ID : | 22816294 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
a) Obtaining Fmoc-L-Lys(Fmoc)-4-Abz-AM-MBHA- 15 mmol of the resin pMBHA with a functionalization of 0.6 mmol/g were treated with 40% TFA in DCM (1×2 min+1×10 min+1×20 min), DCM (5×1 min) and a solution of 15% DIEA in DCM (3×2 min). The resin was washed with DCM (5×1 min) and DMF (3×1 min). 1.5 equiv of Fmoc-AM-OH were incorporated into the resin in the presence of 1.5 equiv of DIPCDI and 1.5 equiv of HOBt using DMF/DCM (1/1; v/v) as a solvent for 1 hour. The resin was then washed with DMF (3×1 min). The Fmoc N-terminal group was deprotected as described in the general methods (20% piperidine in DMF, 1×1 min+1×5 min). The resin was washed with DMF (5×1 min), after which 4 equiv of Fmoc-4-Abz-OH were incorporated in the presence of 4 equiv of DIPCDI and 4 equiv of HOBt using DMF as a solvent for 1 hour. It was filtered and the reaction was repeated adding 2 equiv of Fmoc-4-Abz-OH in the presence of 2 equiv of DIPCDI and 2 equiv of HOBt using DMF as a solvent for 19 hours. The resin was then washed as described in the general methods and the deprotection treatment of the Fmoc group was carried out to incorporate the following amino acid. 5 equiv of Fmoc-L-Lys(Fmoc)-OH were incorporated into the unprotected peptidyl resin in the presence of 5 equiv of DIPCDI and 5 equiv of HOBt using DMF as a solvent for 2 hours. It was filtered and the reaction was repeated applying 5 equiv of Fmoc-L-Lys(Fmoc)-OH in the presence of 5 equiv of DIPCDI and 5 equiv of HOBt using DMF as a solvent for 20 hours. The peptidyl resin was washed with DMF (5×1 min), DCM (4×1 min), diethyl ether (4×1 min) and was dried under vacuum. |