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Chemical Structure| 89793-12-4 Chemical Structure| 89793-12-4
Chemical Structure| 89793-12-4

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Product Details of Ethyl 2-chloropyrimidine-5-carboxylate

CAS No. :89793-12-4
Formula : C7H7ClN2O2
M.W : 186.60
SMILES Code : ClC1=NC=C(C=N1)C(=O)OCC
MDL No. :MFCD09863164
InChI Key :IEMKQRSOAOPKRJ-UHFFFAOYSA-N
Pubchem ID :10487815

Safety of Ethyl 2-chloropyrimidine-5-carboxylate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of Ethyl 2-chloropyrimidine-5-carboxylate

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 89793-12-4 ]
  • Downstream synthetic route of [ 89793-12-4 ]

[ 89793-12-4 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 89793-12-4 ]
  • [ 98-80-6 ]
  • [ 85386-14-7 ]
YieldReaction ConditionsOperation in experiment
65% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In 1,4-dioxane at 100℃; General procedure: To a solution of and halide in the indicated solvent is added boronic acid or ester, carbonate base, and palladium catalyst at room temperature. After stirring at 100 °C overnight, the mixture is cooled and concentrated.Following Procedure B using ii (500 mg, 2.67 mrnol). dioxane (10 mL), phenylboronic acid (650 mg, 5.36 mmoi), potassium carbonate (1.85 g. 13.4 mmol), and Pd(dppf)C12 (50 mg), then purified by silica gel column chromatography (EA:PE = 1:100 to 1:50) to give 20 as a white solid (400 mg, 65percent yield). (MS: M+Hi 229.1)
References: [1] Patent: WO2017/176812, 2017, A1, . Location in patent: Paragraph 0215; 0248.
  • 2
  • [ 89793-12-4 ]
  • [ 1339928-25-4 ]
References: [1] Patent: US9249156, 2016, B2, .
[2] Patent: US9249156, 2016, B2, .
[3] Patent: WO2018/85342, 2018, A1, .
[4] Patent: WO2018/85342, 2018, A1, .
 

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