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Type HazMat fee for 500 gram (Estimated)
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Chemical Structure| 627-03-2 Chemical Structure| 627-03-2
Chemical Structure| 627-03-2

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Ethoxyacetic acid is an endogenous metabolite.

Synonyms: Ethoxyacetic acid

4.5 *For Research Use Only !

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Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

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Product Details of Ethoxyacetic acid

CAS No. :627-03-2
Formula : C4H8O3
M.W : 104.10
SMILES Code : O=C(O)COCC
Synonyms :
Ethoxyacetic acid
MDL No. :MFCD00004310
InChI Key :YZGQDNOIGFBYKF-UHFFFAOYSA-N
Pubchem ID :12301

Safety of Ethoxyacetic acid

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:3265
Packing Group:

Application In Synthesis of Ethoxyacetic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 627-03-2 ]

[ 627-03-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 627-03-2 ]
  • [ 2734-70-5 ]
  • N-(2,6-dimethoxyphenyl)-2-ethoxyacetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20℃; To a solution of 2-ethoxyacetic acid (4.1 g, 39.2 mmol) and <strong>[2734-70-5]2,6-dimethoxyaniline</strong> (5 0 g, 32.6mmol) in DCM (100 mL) were added DMAP (200 mg, 1.6 mmol) and EDCI (7.5 g, 39 2 mmol) at room temperature. The resulted mixture was stirred at room temperature overnight. The mixture was diluted with EtOAc (500 mL), washed with veater (3*100 mL) and brine (150 mL), dried over anhydrous Na2S04 and concentrated in vacuo. The residue was purified by flash chromatography eluting with PE/ EtOAc (20/1-1/1) to afford the title compound as a white solid. NMR (400 MHz, DMSO-de) d: 8.53 (s, 1H), 7.21 (t, J = 8.4 Hz, 1H), 6.68 (d, J = 8.4 Hz, 2H), 3.95 (s, 2H), 3.72 (s, 6H), 3.57 (d, J = 7.0 Hz, 2H), 1.19 (t, J = 7.0 Hz, 3H). LC-MS: m/z 240.1 (M+H)+
 

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