Home Cart Sign in  
Chemical Structure| 480-40-0 Chemical Structure| 480-40-0
Chemical Structure| 480-40-0

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

Chrysin, an analog of apigenin, demonstrates inhibition of aromatase and the phosphorylation of PLCY2 and PKC activities. It can be isolated from the blue passion flower (passiflora caerulea) with anti-inflammatory and anti-thrombotic activities etc..

Synonyms: 5,7-Dihydroxyflavone; 5,7-DHF; Galangin flavanone.

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of Chrysin

CAS No. :480-40-0
Formula : C15H10O4
M.W : 254.24
SMILES Code : O=C1C=C(C2=CC=CC=C2)OC3=CC(O)=CC(O)=C13
Synonyms :
5,7-Dihydroxyflavone; 5,7-DHF; Galangin flavanone.
MDL No. :MFCD00006834
InChI Key :RTIXKCRFFJGDFG-UHFFFAOYSA-N
Pubchem ID :5281607

Safety of Chrysin

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Chrysin

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 480-40-0 ]

[ 480-40-0 ] Synthesis Path-Downstream   1~7

  • 3
  • [ 480-40-0 ]
  • [ 480-39-7 ]
  • 5,7-dihydroxy-2-cyclohexyl-4H-1-benzopyran-4-one [ No CAS ]
  • 4
  • [ 480-40-0 ]
  • [ 1088-08-0 ]
  • [ 480-39-7 ]
  • 5
  • [ 40299-87-4 ]
  • [ 480-40-0 ]
  • 5-hydroxy-7-(2-morpholino-2-oxoethoxy)flavone [ No CAS ]
  • 6
  • [ 480-40-0 ]
  • [ 3792-04-9 ]
  • 2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)-N-(2-(trifluoromethyl)phenyl)acetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
94% With potassium carbonate; In N,N-dimethyl-formamide; at 20℃; for 24h; Chrysin (1) (50 mg, 0.20 mmol), <strong>[3792-04-9]2-chloro-N-(2-(trifluoromethyl)phenyl)acetamide</strong> (6) (49 mg,0.21 mmol) and anhydrous potassium carbonate (28 mg, 0.20 mmol) were dissolved in DMF (2 mL).The reaction mixture was stirred at room temperature for 24 h, then, it was poured into water (30mL). After filtering off the precipitate, the filtrate was extracted with DCM (3 x 30 mL). The combined organic layer was dried over MgSO4 and concentrated in vacuo. The filtered precipitationand the crude product obtained by extraction were purified separately with preparative TLC (DCM: MeOH = 40 : 1). Combining the pure products 84 mg (94 %) of compound 11 was isolated as a whitesolid. M.p.: 263 C (decomp.). TLC (DCM : MeOH = 40 : 1); Rf = 0.64.
  • 7
  • [ 480-40-0 ]
  • [ 3792-04-9 ]
  • N-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)-2-(2-(trifluoromethyl)phenoxy)acetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
28% With potassium carbonate; In N,N-dimethyl-formamide; at 75℃; for 9h; Chrysin (1) (100 mg, 0.39 mmol), <strong>[3792-04-9]2-chloro-N-(2-(trifluoromethyl)phenyl)acetamide</strong> (6) (98 mg,0.41 mmol) and anhydrous potassium carbonate (112 mg, 0.81 mmol) were dissolved in DMF (4 mL).The reaction mixture was stirred at 75 C for 9 h, then, it was poured into water (30 mL). Afterfiltering off the precipitate, the filtrate was diluted with saturated NaCl solution (30 mL) andextracted with DCM (4 x 30 mL). The combined organic layer was washed with water (30 mL), driedover MgSO4 and concentrated in vacuo. The filtered precipitation and the crude product obtained byextraction were purified separately with preparative TLC (DCM : MeOH = 60 : 1). Combining thepure products 50 mg (28 %) of compound 20 was isolated as a white solid. M.p.: 210-212 C. TLC(DCM : MeOH = 60 : 1); Rf = 0.71.
 

Historical Records

Categories