Structure of Bosutinib
CAS No.: 380843-75-4
*Storage: {[sel_prStorage]}
*Shipping: {[sel_prShipping]}
The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Bosutinib is an inhibitor of Src and Abl with IC50 of 1.2 nM and 1 nM.
Synonyms: SKI-606
4.5
*For Research Use Only !
Change View
Size | Price | VIP Price | US Stock |
Global Stock |
In Stock | ||
{[ item.pr_size ]} |
Inquiry
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price, item.discount_usd) ]} {[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]} |
Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]} | Inquiry {[ item.pr_usastock ]} In Stock Inquiry - | {[ item.pr_chinastock ]} {[ item.pr_remark ]} In Stock 1-2 weeks - Inquiry - | Login | - + | Inquiry |
Please Login or Create an Account to: See VIP prices and availability
US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days
1-2weeks
Inquiry
{[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price, item.pr_usd) ]}
Inquiry
{[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price, item.vip_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
In Stock
- +
Please Login or Create an Account to: See VIP prices and availability
US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Leclercq, Gabrielle ;
Abstract: T cell bispecific antibodies (TCBs) are a novel class of T cell engagers redirecting T cells towards tumor cells, facilitating the formation of a cytotoxic synapse and resulting in tumor celllysis. On-target activity of TCBs may come with a risk of Cytokine Release Syndrome (CRS), characterized by elevated levels of pro-inflammatory cytokines in the serum, such as IL-6, IL-1β, TNF-α or IFN-γ and over activation of immune cells. Besides, the expression of the tumorassociated antigen on healthy cells may induce off-tumor activity of the TCB and contribute to inflammation. Despite the use of step-up dosing, glucocorticoids, or tocilizumab to manage or prevent these safety liabilities, they remain the major dose-limiting toxicities associated with the treatment of T cell engagers, highlighting the need to develop preventive mitigation treatments. To this aim, we investigated the biological mechanisms and the chronology of events involved in TCB-mediated cytokine release and explored mitigation strategies that might retain profound treatment efficacy while reducing cytokine release. Using an in vitro co-culture of peripheral blood mononuclear cells (PBMCs) or total leukocytes(PBMCs + neutrophils) and target cells with the respective TCBs, or whole blood treated with a B cell depleting TCB, we confirmed the contribution of T cell and myeloid cells and revealed the role of neutrophils in the TCB-mediated cytokine release. In the same model, the use of anticytokine neutralizing antibodies provided insights into the chronology of events triggering the cascade of cytokines after TCB stimulation. Ultimately this work guided the evaluation of mitigation strategies directed against T-cell derived cytokine release by targeting kinases involved in signaling pathways downstream of the T cell receptor (TCR) after stimulation with TCBs. A novel small molecule-kinase inhibitors screen identified mTOR, JAK and Src inhibitors as candidates to switch-off T-cell derived cytokine release. We validated the effects of these kinase inhibitors and fine-tuned their effective doses in in vitro co-cultures of peripheral blood mononuclear cells (PBMCs) and tumor cells with the respective TCBs. In vivo, we used nontumor or tumor-bearing-humanized NSG mice to assess the effect of mTOR, JAK and Srcinhibitors on CD19-TCB-mediated cytokine release and anti-tumor efficacy. Altogether, we confirmed the biological mechanisms of the TCB-mediated cytokine cascade and revealed the contribution of neutrophils. Our work on kinase inhibitors highlights their differential activities on the inhibition of cytokine release and/or T cell cytotoxicity and demonstrates the decoupling between both mechanisms. Our data open new horizons for the prophylactic mitigation of CRS with the use of FDA approved mTOR and JAK inhibitors or the transient use of the Src inhibitor dasatinib. Finally, our results also indicate that dasatinib may serve as an “antidote” against adverse events related to the treatment with TCBs such as high grade CRS or unpredictable off-tumor activity of TCBs, a strategy which is now implemented the clinic.
Show More >
Purchased from AmBeed: 302962-49-8 ; 943319-70-8 ; 162635-04-3 ; 53123-88-9 ; 380843-75-4
Show More >
CAS No. : | 380843-75-4 |
Formula : | C26H29Cl2N5O3 |
M.W : | 530.45 |
SMILES Code : | N#CC1=C(NC2=CC(OC)=C(Cl)C=C2Cl)C3=CC(OC)=C(OCCCN4CCN(C)CC4)C=C3N=C1 |
Synonyms : |
SKI-606
|
MDL No. : | MFCD07367846 |
InChI Key : | UBPYILGKFZZVDX-UHFFFAOYSA-N |
Pubchem ID : | 5328940 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H319-H413 |
Precautionary Statements: | P305+P351+P338 |
Target |
|
In Vitro:
Concentration | Treated Time | Description | References |
BEAS-2B cells | 5 or 10 μM | 30 min | To investigate the inhibitory effect of Bosutinib on Src kinase activity, it was found that pretreatment with Bosutinib significantly inhibited O3-induced EGFR phosphorylation. | PMC4348738 |
ParC5 cells | 0.1–1.0 μM | 30 min | Bosutinib inhibited IR-induced apoptosis in ParC5 cells and suppressed phosphorylation of PKC δ at Y64 and Y155. | PMC5587414 |
KRAS mutant non-small cell lung cancer cells | 0.1, 0.5, 1 μM | Bosutinib inhibited migration and invasion in KRAS mutant cells but had no significant effect on KRAS wild-type cells. | PMC3930897 | |
NCI-H1792 cells | 0.5, 1 μM | Bosutinib-induced inhibition of cell migration and invasion was dependent on ACK1, not SRC. | PMC3930897 | |
Human umbilical vein endothelial cells | 0.5 μM | 3 h | To investigate the effect of Bosutinib on human umbilical vein endothelial cells, results showed that Bosutinib treatment did not affect the phosphorylation of eNOS. | PMC8516812 |
K562DOX cells | 1 μM | 1 h | To evaluate the role of ABCB1 in bosutinib transport, results showed the lowest intracellular level of bosutinib in K562DOX cells | PMC4491863 |
K562S cells | 1 μM | 1 h | To evaluate bosutinib transport in normal cells, results showed high intracellular levels of bosutinib in K562S cells | PMC4491863 |
Human umbilical vein endothelial cells | 0.5 μM | 3 h | To investigate the effect of Bosutinib on eNOS phosphorylation in endothelial cells, results showed that Bosutinib treatment did not affect eNOS phosphorylation. | PMC8516812 |
In Vivo:
Administration | Dosage | Frequency | Description | References |
Mice | KRT5Cre/tdTomatoLoxP transgenic mice | Tail vein injection | 30 mg/kg | Single injection, observed for 3 hours | To study the effect of SKI606 on the retraction of basal cell axiopodia, results showed that SKI606 induced the retraction of axiopodia. | PMC4754344 |
Mice | Endothelial cell-specific c-Abl knockout mice | Oral | 100 mg/kg | Once daily for 4 to 7 days | To investigate the effect of Bosutinib on blood pressure, results showed that Bosutinib treatment increased blood pressure in mice, and this effect was independent of endothelial c-Abl. | PMC8516812 |
Nude mice | K562S, K562DOX, and K562DOX/sh P-GP xenograft model | Oral | 150 mg/kg | Once daily, 5 days/week for 2 weeks | To evaluate the effect of ABCB1 overexpression on the anti-tumor activity of bosutinib, results showed that K562DOX mice had a limited response to bosutinib treatment and relapsed, while K562DOX/sh P-GP mice were fully sensitive to treatment | PMC4491863 |
Mice | Endothelial cell-specific c-Abl knockout mice | Oral gavage | 100 mg/kg | Once daily for 4 to 7 days | To investigate the effect of Bosutinib on blood pressure and its mechanism, results showed that Bosutinib increased blood pressure by upregulating soluble epoxide hydrolase (sEH), and the sEH inhibitor TPPU reversed this effect. | PMC8516812 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT02551718 | Acute Leukemia of Ambiguous Li... More >>neage Recurrent Adult Acute Lymphoblastic Leukemia Recurrent Adult Acute Myeloid Leukemia Recurrent Childhood Acute Lymphoblastic Leukemia Recurrent Childhood Acute Myeloid Leukemia Refractory Acute Myeloid Leukemia Refractory Adult Acute Lymphoblastic Leukemia Refractory Childhood Acute Lymphoblastic Leukemia Less << | Not Applicable | Recruiting | - | United States, Washington ... More >> Fred Hutch/University of Washington Cancer Consortium Recruiting Seattle, Washington, United States, 98109 Contact: Pamela S. Becker 206-616-1589 pbecker@u.washington.edu Principal Investigator: Pamela S. Becker Less << |
NCT03610971 | Chronic Phase Chronic Myeloid ... More >>Leukemia Chronic Myeloid Leukemia, Chronic Phase Less << | Phase 2 | Not yet recruiting | January 2022 | United States, Florida ... More >> H. Lee Moffitt Cancer Center and Research Institute Not yet recruiting Tampa, Florida, United States, 33612 Contact: Anthony McLaughlin 813-745-5941 anthony.mclaughlin@moffitt.org Contact: Kendra Sweet, M.D. 813-745-8986 kendra.sweet@moffitt.org Principal Investigator: Kendra Sweet, M.D. Less << |
NCT03746054 | Chronic Myeloid Leukemia (CML) | Phase 3 | Not yet recruiting | March 2023 | - |
NCT02269267 | Leukemia, Myeloid, Chronic | Phase 2 | Active, not recruiting | December 2021 | United States, California ... More >> Helen Diller Family Comprehensive Cancer Center University of California San Francisco, California, United States, 94143 United States, Florida Moffit Cancer Center Tampa, Florida, United States, 33612 United States, Georgia Winship Cancer Institute of Emory University Atlanta, Georgia, United States, 30322 United States, Illinois The University of Chicago Chicago, Illinois, United States, 60637 The University of Chicago Medicine Comprehensive Cancer Center at Silver Cross New Lenox, Illinois, United States, 60451 United States, Massachusetts Beth Israel Deaconess Medical Center (Satellite site of Dana Farber) Boston, Massachusetts, United States, 02215 Dana Farber Cancer Institute Boston, Massachusetts, United States, 02215 United States, Michigan Karmanos Cancer Institute of Wayne State University Detroit, Michigan, United States, 48201 United States, New York Roswell Park Cancer Institute Buffalo, New York, United States, 14263 Weill Medical College of Cornell University New York, New York, United States, 10021 Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27710 United States, Texas MD Anderson Cancer Center Houston, Texas, United States, 77054 United States, Utah University of Utah Huntsman Cancer Institute Salt Lake City, Utah, United States, 84132-2408 United States, Washington Fred Hutchinson Cancer Research Center Seattle, Washington, United States, 98109-1024 United States, Wisconsin Froedtert Hospital & Medical College of Wisconsin Milwaukee, Wisconsin, United States, 53226 Less << |
NCT02767063 | Leukemia, Myeloid, Chronic-Pha... More >>se Less << | Phase 1 Phase 2 | Recruiting | June 2021 | France ... More >> Martine GARDEMBAS Recruiting Angers, France Contact: Martine GARDEMBAS 02.41.35.44.75 MaGardembas@chu-angers.fr Pascale CONY.MAKHOUL Recruiting Annecy, France Contact: Pascale CONY.MAKHOUL 04.50.63.64.31 pconymakhoul@ch-annecygenevois.fr Thorsten BRAUN Recruiting Bobigny, France Contact: Thorsten BRAUN 01.48.95.54.58 Thorsten.braun@avc.aphp.fr Etienne Recruiting Bordeaux, France Contact: Gabriel Etienne 05.56.33.04.76 G.Etienne@bordeaux.unicancer.fr CHU Côte de Nacre Not yet recruiting Caen, France Contact: Hyacynthe Johnson-Ansah 02.31.27.25.39 Johnsonansah-a@chu-caen.fr CHU Estaing Not yet recruiting Clermont-Ferrand, France Contact: Marc BERGER mberger@chu-clermontferrand.fr CH Henri Mondor Recruiting Créteil, France Contact: ROY Lydia Rousselot Recruiting Le Chesnay, France Contact: Philippe Rousselot 01.39.63.89.09 phrousselot@ch-versailles.fr CHU Lille Recruiting Lille, France Contact: COITEUX Valérie CHU de LIMOGES Not yet recruiting Limoges, France Contact: Amélie PENOT 05.55.05.66.42 Amelie.penot@chu-limoges.fr Franck NICOLINI Recruiting Lyon, France Contact: Franck NICOLINI 04.72.11.74.01 franck.nicolini@chu-lyon.fr Institut P Calmette Recruiting Marseille, France Contact: CHARBONNIER Aude Viviane DUBRUILLE Recruiting Nantes, France Contact: Viviane DUBRUILLE 02.40.08.32.71 Viviane.dubruille@chu-nantes.fr Hopital l'Archet Not yet recruiting Nice, France Contact: Laurence LEGROS 04.92.03.58.41 legros.l@chu-nice.fr Eric JOURDAN Recruiting Nimes, France Contact: Eric JOURDAN 04.66.68.32.31 eric.jourdan@chu-nimes.fr Hôpital La Source Recruiting Orléans, France Contact: BENBRAHIM Omar Delphine REA _St louis Recruiting Paris, France Contact: Delphine REA 01.42.49.96.49 delphine.rea@aphp.fr Simona LAPUSAN_St Antoine Recruiting Paris, France Contact: Simona LAPUSAN 01.49.28.34.42 Simona.lapusan@sat.aphp.fr Cayssials Recruiting Poitiers, France Contact: Emilie Cayssials : 05.49.44. 44.72 e.cayssials@chu-poitiers.fr CHU de Rennes - Pontchaillou Recruiting Rennes, France Contact: ESCOFFRE-BARBE Martine Hôpital René Huguenin Not yet recruiting Saint-Cloud, France Contact: Sylvie GLAISNER 01.47.11.15.30 Sylvie.glaisner@curie.net Institut Universitaire contre le Cancer Not yet recruiting Toulouse, France Contact: Françoise HUGUET 05.31.15.63.56 Huguet.françoise@iuct-oncopole.fr CHU Tours Not yet recruiting Tours, France Contact: DARTIGEAS Caroline Less << |
NCT00406406 | Healthy | PHASE1 | COMPLETED | 2025-08-07 | Utrecht, 3584 CJ, Netherlands |
NCT00499538 | Healthy | PHASE1 | COMPLETED | 2025-09-07 | San Antonio, Texas, 78217, Uni... More >>ted States Less << |
NCT00434486 | Healthy | PHASE1 | COMPLETED | 2025-03-07 | Philadelphia, Pennsylvania, 19... More >>148, United States Less << |
NCT02693535 | Lymphoma, Non-Hodgkin ... More >> Multiple Myeloma Advanced Solid Tumors Less << | Phase 2 | Recruiting | - | - |
NCT01001936 | Tumors | PHASE1 | COMPLETED | 2025-12-08 | - |
NCT02921477 | Mild Cognitive Impairment ... More >> Dementia Less << | Phase 1 | Unknown | September 2018 | United States, California ... More >> Neurological Associates of West LA Santa Monica, California, United States, 90403 Less << |
NCT02638467 | Leukemia Myel... More >>ogenous Chronic BCR-ABL Positive Less << | Phase 2 | Recruiting | January 2019 | Italy ... More >> ASST-Monza Recruiting Monza, Italy/MB, Italy, 20900 Contact: Carlo Gambacorti-Passerini, MD +390392339553 carlo.gambacorti@unimib.it Principal Investigator: Carlo Gambacorti-Passerini, MD Ospedale San Raffaele Recruiting Milano, MI, Italy, 20132 Contact: Fabio Ciceri, MD +390226437703 fabio.ciceri@hsr.it Less << |
NCT00757341 | Healthy Subjects | PHASE1 | COMPLETED | 2025-12-08 | Tacoma, Washington, 98418, Uni... More >>ted States Less << |
NCT00777530 | Breast Cancer ... More >> Tumors Leukemia Less << | Phase 1 | Completed | - | Netherlands ... More >> Utrecht, Netherlands, 3584 Less << |
NCT00195260 | Neoplasms | Phase 1 | Completed | - | United States, Alabama ... More >> Pfizer Investigational Site Birmington, Alabama, United States, 35233 United States, Arizona Pfizer Investigational Site Scottsdale, Arizona, United States, 85258 United States, California Pfizer Investigational Site Los Angeles, California, United States, 90033 United States, Florida Pfizer Investigational Site Tampa, Florida, United States, 33612 United States, Georgia Pfizer Investigational Site Atlanta, Georgia, United States, 30341 United States, Indiana Pfizer Investigational Site Indianpolis, Indiana, United States, 46202 United States, Maryland Pfizer Investigational Site Baltimore, Maryland, United States, 21287 United States, Michigan Pfizer Investigational Site Detroit, Michigan, United States, 48202 Pfizer Investigational Site Lansing, Michigan, United States, 48910 United States, New York Pfizer Investigational Site New York, New York, United States, 10016 Pfizer Investigational Site New York, New York, United States, 10032 United States, North Carolina Pfizer Investigational Site Charlotte, North Carolina, United States, 28203 Pfizer Investigational Site Charlotte, North Carolina, United States, 28211 Pfizer Investigational Site UNC Chapel Hill, North Carolina, United States, 27514 Pfizer Investigational Site UNC Chapel Hill, North Carolina, United States, 27759 United States, Ohio Pfizer Investigational Site Cleveland, Ohio, United States, 44106-1736 United States, Texas Pfizer Investigational Site San Antonio, Texas, United States, 78258 Pfizer Investigational Site Tyler, Texas, United States, 75702 United States, Washington Pfizer Investigational Site Seattle, Washington, United States, 98104 Less << |
NCT00319254 | Breast Neoplasms ... More >> Neoplasm Metastasis Less << | Phase 2 | Completed | - | United States, California ... More >> Pfizer Investigational Site Duarte, California, United States, 91010-3000 Pfizer Investigational Site Santa Monica, California, United States, 90404 United States, Florida Pfizer Investigational Site Tampa, Florida, United States, 33612 United States, Ohio Pfizer Investigational Site Cleveland, Ohio, United States, 44195 Australia, New South Wales Pfizer Investigational Site Darlinghurst, New South Wales, Australia, 2010 France Pfizer Investigational Site Dijon, France, 21034 Pfizer Investigational Site Saint-Herblain, France, 44805 Hong Kong Pfizer Investigational Site Pokfulam, Hong Kong Malta Pfizer Investigational Site Floriana, Malta, VLT 14 Poland Pfizer Investigational Site Lodz, Poland, 90-553 Pfizer Investigational Site Wroclaw, Poland, 51-124 Russian Federation Pfizer Investigational Site Moscow, Russian Federation, 115478 Ukraine Pfizer Investigational Site Dnipropetrovsk, Ukraine, 49102 Pfizer Investigational Site Sumy, Ukraine, 40005 Pfizer Investigational Site Uzhgorod, Ukraine, 88014 Less << |
NCT00880009 | Breast Cancer | Phase 2 | Terminated(See termination rea... More >>son in detailed description.) Less << | - | United States, California ... More >> Pfizer Investigational Site Whittier, California, United States, 90603 United States, Illinois Pfizer Investigational Site Joliet, Illinois, United States, 60435 Pfizer Investigational Site Niles, Illinois, United States, 60714 United States, Massachusetts Pfizer Investigational Site Boston, Massachusetts, United States, 02114 United States, Michigan Pfizer Investigational Site Detroit, Michigan, United States, 84202 Belgium Pfizer Investigational Site Wilrijk, Belgium, 2610 China, Beijing Pfizer Investigational Site Beijing, Beijing, China, 100021 Hong Kong Pfizer Investigational Site Hong Kong, Hong Kong Hungary Pfizer Investigational Site Budapest, Hungary, 1122 Poland Pfizer Investigational Site Warszawa, Poland, 04125 Singapore Pfizer Investigational Site Singapore, Singapore, 308433 Less << |
NCT00880009 | - | Terminated(See termination rea... More >>son in detailed description.) Less << | - | - | |
NCT00759837 | Breast Cancer|Leukemia, Myeloi... More >>d, Chronic Less << | PHASE1 | COMPLETED | 2025-05-09 | Warsaw, 02-507, Poland |
NCT00914121 | Healthy Subjects | Phase 1 | Completed | - | United States, Washington ... More >> Tacoma, Washington, United States, 98418 Less << |
NCT03297606 | Lymphoma, Non-Hodgkin ... More >> Multiple Myeloma Advanced Solid Tumors Less << | Phase 2 | Recruiting | September 2021 | Canada, British Columbia ... More >> BCCA - Vancouver Cancer Centre Recruiting Vancouver, British Columbia, Canada, V5Z 4E6 Contact: Daniel John Renouf 604 877-6000 ext 672357 Canada, Ontario London Regional Cancer Program Recruiting London, Ontario, Canada, N6A 5W9 Contact: Stephen Welch 519 685-8640 Ottawa Hospital Research Institute Recruiting Ottawa, Ontario, Canada, K1H 8L6 Contact: John Hilton 613 737-7700 ext 70179 University Health Network Recruiting Toronto, Ontario, Canada, M5G 2M9 Contact: Lillian Siu 416 946-2911 Canada, Quebec The Jewish General Hospital Recruiting Montreal, Quebec, Canada, H3T 1E2 Contact: Cristiano Ferrario 514 398-8307 Less << |
NCT00319254 | - | Completed | - | - | |
NCT03747679 | CML | Phase 1 | Not yet recruiting | December 20, 2018 | Belgium ... More >> Pfizer Clinical Research Unit Not yet recruiting Brussels, Belgium, B-1070 Less << |
NCT02228382 | Previously Treated PH + CML | PHASE4 | TERMINATED | 2020-10-13 | Keck Hospital of USC, Los Ange... More >>les, California, 90033, United States|LAC+USC Medical Center, Los Angeles, California, 90033, United States|USC/Norris Comprehensive Cancer Center, Los Angeles, California, 90033, United States|Sylvester Deerfield Beach, Deerfield Beach, Florida, 33442, United States|University of Miami Hospital & Clinics, Miami, Florida, 33136, United States|Indiana Blood and Marrow Transplantation-Clinic, Indianapolis, Indiana, 46237, United States|Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, 21287, United States|Siteman Cancer Center - West County, Creve Coeur, Missouri, 63141-6337, United States|Barnes-Jewish Hospital, Saint Louis, Missouri, 63110, United States|Washington University School of Medicine, Saint Louis, Missouri, 63110, United States|Siteman Cancer Center - South County, Saint Louis, Missouri, 63129, United States|Weill Cornell Medical College - New York-Presbyterian Hospital, New York, New York, 10021, United States|Seattle Cancer Care Alliance, Seattle, Washington, 98109, United States|Medizinische Universitaet Innsbruck, Innsbruck, 6020, Austria|Ordensklinikum Linz Gmbh Barmherzige Schwestern, Linz, 4010, Austria|Institut Bergonie, Bordeaux Cedex 09, 33076, France|Centre Hospitalier de Versailles (CHV)-Hopital Andre Mignot Service d'Hematologie Clinique- Oncology, Le Chesnay Cedex, 78157, France|Centre Regional De Lutte Contre Le Cancer, Marseille, 13009, France|Hopital Archet I, Nice Cedex 3, 06202, France|Institut Universitaire du Cancer Toulouse - Oncopole, Toulouse Cedex 9, 31059, France|CHU Brabois, Vandoeuvre-les-Nancy cedex, 54511, France|RWTH Uniklinik Aachen Klinik fur Onkologie, Hamatologie und Stammzelltransplantation, Aachen, 52074, Germany|Charite - Universitaetsmedizin Berlin - Campus Virchow-Klinikum (CVK), Berlin, 13353, Germany|Universitaetsklinikum Hamburg-Eppendorf, Hamburg, 20246, Germany|Klinik fur Innere Medizin II, Jena, 07747, Germany|Universitaetsklinikum Koeln (AoeR), Koeln, 50937, Germany|III. Medizinische Klinik Universitaetsmedizin Mannheim, Mannheim, D-68167, Germany|AOU Policlinico Consorziale di Bari - UO Ematologia con Trapianto, Bari, BA, 70124, Italy|A.O.U. Policlinico S. Orsola-Malpighi, Bologna, BO, 40138, Italy|Azienda Socio Sanitaria Territoriale - ASST Monza, Monza, MB, 20900, Italy|Ospedale S. Eugenio - UOC Ematologia, Rome, RM, 00144, Italy|AOU San Luigi Gonzaga SCDU Medicina Interna II ad indirizzo Ematologico, Orbassano, TO, 10043, Italy|AOU Policlinico Vittorio Emanuele-P.O.G. Rodolico, Catania, 95123, Italy|SOD Ematologia, Firenze, 50134, Italy|A.O. Ospedale Niguarda Ca Granda - SC Ematologia, Milano, 20162, Italy|Haukeland Universitetssjukehus, Bergen, 5021, Norway|St Olav Hospital, Trondheim, 7030, Norway|Hospital Universitario Quiron Madrid, Pozuelo de Alarcon, Madrid, 28223, Spain|Hospital Universitari Vall d' Hebron, Barcelona, 08035, Spain|Hospital Universitari Vall d'Hebron, Barcelona, 08035, Spain|Hospital Clinic De Barcelona, Barcelona, 08036, Spain|Hospital Universitario de La Princesa, Madrid, 28006, Spain|Hospital Universitario Ramon y Cajal, Madrid, 28034, Spain|Hospital Clinico Universitario de Salamanca, Salamanca, 37007, Spain|Hospital Universitari i Politecnic La Fe de Valencia, Valencia, 46026, Spain|Hospital de dia Quiron Zaragoza, Zaragoza, 50012, Spain|Hematologiskt centrum, Stockholm, 171 76, Sweden|Akademiska Sjukhuset, Uppsala, 751 85, Sweden Less << |
NCT00725426 | Healthy | PHASE1 | COMPLETED | 2025-08-08 | - |
NCT00793546 | Advanced Breast Cancer | Phase 2 | Terminated(See termination rea... More >>son in detailed description.) Less << | - | - |
NCT01233882 | Renal Disease, End-Stage ... More >> Renal Insufficiency, Chronic Renal Insufficiency, Acute Less << | Phase 1 | Completed | - | United States, Florida ... More >> Pfizer Investigational Site DeLand, Florida, United States, 32720 Pfizer Investigational Site Gainesville, Florida, United States, 32608 Pfizer Investigational Site Miami, Florida, United States, 33169 Pfizer Investigational Site Orlando, Florida, United States, 32806 United States, Minnesota Pfizer Investigational Site Saint Paul, Minnesota, United States, 55114 Less << |
NCT00195260 | - | Completed | - | - | |
NCT00952913 | Healthy | Phase 1 | Completed | - | United States, Florida ... More >> Pfizer Investigational Site Miami, Florida, United States, 33126 Less << |
NCT00811070 | Chronic Myelogenous Leukemia | Phase 2 | Completed | - | Japan ... More >> Tohoku University Hospital Sendai-city, Miyagi, Japan, 980-8574 National Cancer Center Hospital Chuo-ku, Tokyo, Japan, 104-0045 Toyohashi Municipal Hospital Aichi, Japan, 441-8570 Japanese Red Cross Nagoya First Hospital Aichi, Japan, 453-8511 Aichi Cancer Center Aichi, Japan, 464-8681 Akita University Hospital Akita, Japan, 010-8543 Chiba University Hospital Chiba, Japan, 260-8677 National Hospital Organization Kyushu Cancer Center Fukuoka, Japan, 811-1395 Harasanshin Hospital Fukuoka, Japan, 812-0033 Kobe City Medical Center General Hospital Hyogo, Japan, 650-0047 Hospital of Hyogo College of Medicine Hyogo, Japan, 663-8501 Kanazawa University Hospital Ishikawa, Japan, 920-8641 Tokai University Hospital Kanagawa, Japan, 259-1193 Kumamoto University Hospital Kumamoto, Japan, 860-8556 University Hospital,Kyoto Prefectural University of Medicine Kyoto, Japan, 602-8566 Okayama University Hospital Okayama, Japan, 700-8558 Osaka University Hospital Osaka, Japan, 565-0871 Kinki University School of Medicine Osaka, Japan, 589-8511 Saga University Hospital Saga, Japan, 846-8501 Hamamatsu Medical Univ. HP Faculty of Medicine Shizuoka, Japan, 431-3192 Tokyo Metropolitan Cancer&Infectious disease Ctr Komagome Hp Tokyo, Japan, 113-8677 Japanese Red Cross Medical Center Tokyo, Japan, 150-8935 Jikei University Hospital Daisan Tokyo, Japan, 201-8601 Less << |
NCT00793546 | - | Terminated(See termination rea... More >>son in detailed description.) Less << | - | - | |
NCT00811070 | - | Completed | - | - | |
NCT00721474 | Healthy Subjects | Phase 1 | Completed | - | United States, Washington ... More >> Tacoma, Washington, United States, 98418 Less << |
NCT01233869 | Polycystic Kidney, Autosomal D... More >>ominant Less << | Phase 2 | Completed | - | - |
NCT01233869 | - | Completed | - | - | |
NCT00934674 | Healthy | Phase 1 | Completed | - | United States, Washington ... More >> Tacoma, Washington, United States, 98418 Less << |
NCT00574873 | Chronic Myeloid Leukemia | Phase 3 | Completed | - | - |
NCT00574873 | - | Completed | - | - | |
NCT02501330 | Chronic Myelogenous Leukemia | COMPLETED | 2024-02-28 | Shibuya-ku, 151-8589, Japan | |
NCT02102633 | Healthy | Phase 1 | Completed | - | United States, Florida ... More >> Pfizer Investigational Site DeLand, Florida, United States, 32720 Less << |
NCT01080365 | Healthy | Phase 1 | Completed | - | United States, Washington ... More >> Pfizer Investigational Site Tacoma, Washington, United States, 98418 Less << |
NCT02058277 | Healthy | Phase 1 | Completed | - | United States, Florida ... More >> Pfizer Investigational Site DeLand, Florida, United States, 32720 Less << |
NCT00959946 | - | Terminated | - | - | |
NCT00959946 | Advanced Breast Cancer (Parts ... More >>1 and 2) Advanced Pancreatic Cancer (Part 1) Advanced Colorectal Cancer (Part 1) Advanced Cholangiocarcinoma (Part 1) Advanced Glioblastoma Multiforme (Part 1) Less << | Phase 1 Phase 2 | Terminated | - | United States, Massachusetts ... More >> Pfizer Investigational Site Boston, Massachusetts, United States, 02114 United States, Michigan Pfizer Investigational Site Detroit, Michigan, United States, 84202 Australia, South Australia Pfizer Investigational Site Adelaide, South Australia, Australia, 5037 Belgium Pfizer Investigational Site Edegem, Belgium, 2650 France Pfizer Investigational Site Saint Herblain, France, 44805 Hong Kong Pfizer Investigational Site Hong Kong, Hong Kong Spain Pfizer Investigational Site Madrid, Spain, 28050 Less << |
NCT01374139 | Philadelphia Chromosome Positi... More >>ve (Ph+) Chronic Myeloid Leukemia (CML) Less << | Phase 1 | Completed | - | Singapore ... More >> Pfizer Investigational Site Singapore, Singapore, 188770 Less << |
NCT02192294 | Healthy | Phase 1 | Completed | - | United Kingdom ... More >> Quotient Clinical Ruddington Fields, Nottingham, United Kingdom, NG11 6JS Less << |
NCT00261846 | Chronic Myeloid Leukemia | PHASE2 | COMPLETED | 2015-08-06 | City of Hope National Medical ... More >>Center, Duarte, California, 91010, United States|HealthONE Presbyterian, Denver, Colorado, 80218, United States|Rocky Mountain Cancer Centers, Denver, Colorado, 80218, United States|Georgetown University Hospital, Washington, D.C., District of Columbia, 20007, United States|Emory Clinic, Atlanta, Georgia, 30322, United States|Emory University Hospital, Atlanta, Georgia, 30322, United States|Winship Cancer Institute, Atlanta, Georgia, 30322, United States|Oncology Specialists, S.C., Niles, Illinois, 60714, United States|Indiana Blood and Marrow Transplantation, Indianapolis, Indiana, 46237, United States|LSU Health Sciences Center, Shreveport, Louisiana, 71103, United States|University Of Maryland Medical Center, Baltimore, Maryland, 21201, United States|University Of Maryland, Baltimore, Maryland, 21201, United States|Roswell Park Cancer Institute, Buffalo, New York, 14263, United States|Hudson Valley Hematology and Oncology Associates, Hawthorne, New York, 10532, United States|Westchester Oncology Hematology Group, P.C., Hawthorne, New York, 10532, United States|Westchester Oncology Hematology, Group, P.C., Hawthorne, New York, 10532, United States|New York Presbyterian Hospital, New York, New York, 10021, United States|New York Presbyterian Hospital, New York, New York, 10065, United States|University of Rochester Cancer Center Pharmacy, Rochester, New York, 14642, United States|University of Rochester Medical Center Strong Memorial Hospital - James P. Wilmot Cancer Center, Rochester, New York, 14642, United States|University of Rochester Medical Center, Rochester, New York, 14642, United States|University of Rochester-James P. Wilmot Cancer Center, Rochester, New York, 14642, United States|University of Rochester, Rochester, New York, 14642, United States|Westchester Medical Center, Valhalla, New York, 10595, United States|Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania, 17033-0850, United States|MD Anderson Cancer Center, Houston, Texas, 77030-4009, United States|The University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, United States|The University of Texas, Houston, Texas, 77030, United States|Virginia Commonwealth University, Richmond, Virginia, 23298-0157, United States|Hospital Italiano de la Plata, La Plata, Provincia de Buenos Aires, 1900, Argentina|Hospital Britanico, Buenos Aires, 1280, Argentina|Academia Nacional de Medicina-Instituto de Investigaciones Hematologicas, Buenos Aires, 1425, Argentina|Instituto Medico Especializado Alexander Fleming, Buenos Aires, 1426, Argentina|Clinica del Sol, Ciudad Autonoma de Buenos Aires, C1425DQI, Argentina|Centro Medico S.A., Corrientes, 3400, Argentina|Hospital Jose Ramon Vidal, Corrientes, 3400, Argentina|Hospital universitario austral, Pcia de Buenos Aires, B1629ODT, Argentina|Royal Adelaide Hospital, Adelaide, South Australia, 5000, Australia|Institute of Medical and Veterinary Science, Adelaide, SA 5000, Australia|Department of Clinical Haematology and Bone Marrow Transplantation, Melbourne, 3181, Australia|Royal Brisbane and Women's Hospital, Queensland, 4029, Australia|Haematology and Oncology Clinics of Australia, Queensland, 4101, Australia|Klinikum Kreuzschwestern Wels, Wels, 4600, Austria|Hospital Brigadeiro da Secretaria de Estado da Saude de Sao Paulo, Jardim Paulista, Sao Paulo/sp - Brazil, CEP: 01401-901, Brazil|Centro de Estudos da Disciplina dr Hematologia da Faculdade de Medicine do ABC, Santo Andre, Sp - Brazil, CEP 09060-650, Brazil|Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Sp Brazil, 05403-000, Brazil|Hospital de Clinicas - Universidade Federal do Parana, Curitiba, PR, CEP: 80060-900, Brazil|Cross Cancer Institute, Edmonton, Alberta, T6G1Z2, Canada|BC Cancer Agency - Cancer Centre for the Southern Interior, Kelowna, British Columbia, V1Y 5L3, Canada|CancerCare Manitoba, Winnipeg, Manitoba, R3E 0V9, Canada|University Health Network Princess Margaret Hospital, Toronto, Ontario, M5G 2M9, Canada|Sir Mortimer B. Davis, Jewish General Hospital, Montreal, Quebec, H3T 1E2, Canada|Instituto Clinico Oncologico del Sur, Temuco, Chile|The First Hospital affiliated to the Medical School of Zhejiang University, Zhejiang, P.r China, 310003, China|Peking Union Medical College Hospital of Chinese Academy of Medical Sciences, Beijing, P.r. China, 100730, China|The Department of Hematology, The Chinese PLA General Hospital, Beijing, P.r. China, 100853, China|The Hematology Hospital of Chinese Academy of Medical Sciences, Tianjin, P.r. China, 300020, China|The Department of Hematology, Ruijin Hospital Affiliated to School of Medicine of Shanghai Jiaotong, Shanghai, 200025, China|Hospital Pablo Tobon Uribe, Medellin, Antioquia, 4459000, Colombia|Fundacion Santa Fe de Bogota, Bogota, Cundinamarca, Colombia|Biomedicum Helsinki, Helsinki, FIN-00029 HUS, Finland|Universitaet Mainz, Mainz, RP, 55101, Germany|University Hospital Carl Gustav Carus, Dresden, 01307, Germany|Universitaetsklinikum Hamburg - Eppendorf, Hamburg, 20246, Germany|Universitaetsklinikum Hamburg-Eppendorf, Hamburg, 20246, Germany|Universitaetsklinikum Magdeburg A. oe. R., Magdeburg, 39120, Germany|III Medizinische Klinik und Poliklinik, Mainz, 55101, Germany|Klinikum der Johann Gutenberg Universitaet Mainz, Mainz, 55131, Germany|Universitaet Mainz Iii. Medizinische Klinik Abteilung Fuer Haematologie, Mainz, D-55101, Germany|Universitaetsklinikum Mainz, Mainz, Germany|III. Medizinische Klinik, Mannheim, 68169, Germany|Pamela Youde Nethersole Eastern Hosp., Chai Wan, Hong Kong|Queen Mary Hospital, Hong Kong, Hong Kong|Fovarosi Onkormanyzat Egyesitett Szent Istvan es Szent Laszlo, Budapest, 1096, Hungary|Christian Medical College, Vellore, Tamil Nadu, 632 004, India|University of Bologna, Bologna, Province of Bologna, 40138, Italy|Azienda Ospedaliero - Universitaria San Luigi Gonzaga, Orbassano, Torino, 10043, Italy|AOU-S.Orsola-Malpighi - Universita degli Studi di Bologna, Bologna, 40138, Italy|Azienda Ospedaliera San Gerardo, Monza, 20900, Italy|The Catholic University of Korea, Seoul St. Mary Hospital, Seoul, 137-701, Korea, Republic of|Dept. of Hematology, Seoul, 138736, Korea, Republic of|Hospital Universitario "Dr. Jose Eleuterio Gonzalez", Nuevo Leon, 64460, Mexico|Centro Oncologico Estatal ISSEMYM, Toluca Estado de Mexico, CP50180, Mexico|VU University Medical Center, Amsterdam, 1081 HV, Netherlands|University Medical Center Groningen, Groningen, 9700 RB, Netherlands|UMCG - Pharmacy, Groningen, 9713 AP, Netherlands|Universitair Medisch Centrum Groningen, Groningen, 9713 GZ, Netherlands|VUMC, The Netherlands, Netherlands|Avd. for blodsykdommer, Trondheim, Norge, 7006, Norway|Hospital Nacional Edgardo Rebagliati Martins, Lima, 11, Peru|State Healthcare Institution, Sverdlovsk Regional Clinical Hospital, Ekaterinburg, 620102, Russian Federation|Kirov Research Institute of Hematology and Blood transfusion of Roszdrav Hematology clinic, Kirov, 610027, Russian Federation|Hematological Research Centre of RAMS, Moscow, 125167, Russian Federation|Moscow regional Clinical Research Institute named after M.F Vladimirsky, Moscow, 129110, Russian Federation|Rostov State Medical University of Roszdrav, Rostov-on Don, 344022, Russian Federation|Saint Petersburg State Medical University Hematology Department, Saint Petersburg, 197022, Russian Federation|Singapore General Hospital, Singapore, 169608, Singapore|University of the Free State, Bloemfontein, 9301, South Africa|University of Cape Town, Cape Town, 7925, South Africa|Johannesburg Hospital, Parktown, 2193, South Africa|Clinical Haematology Unit, Soweto, 2013, South Africa|Hospital Clinic de Barcelona (Hospital Clinic i Provincial), Barcelona, Catalonia, 08036, Spain|Hospital Universitari Clinic de Barcelona, Barcelona, Catalonia, 08036, Spain|Hospital Universitario La Princesa, Madrid, 28006, Spain|Hospital Clinico Universitario de Valencia (CHUV), Valencia, 46010, Spain|Akademiska University Hospital, Uppsala, 75185, Sweden|National Taiwan University Hospital - Section of Hematology-Oncology, Taipei 100, 10018, Taiwan|Northern Centre for Cancer Care - The Newcastle Upon Tyne Hospitals - NHS Foundation Trust, Newcastle Upon Tyne, North East England, NE7 7DN, United Kingdom|School of Clinical and Laboratory Sciences, University upon Tyne, North East England, NE1 7RU, United Kingdom|Hammersmith Hospital, London, W12 0HS, United Kingdom|Clinical Research Facility, Newcastle Upon Tyne, North East England, NE1 4LP, United Kingdom Less << |
NCT01025570 | Pancreatic Cancer | Phase 1 | Terminated(Terminated due to s... More >>low accrual) Less << | - | United States, California ... More >> UCSF Helen Diller Family Comprehensive Cancer Center San Francisco, California, United States, 94115 United States, Utah Huntsman Cancer Institute, University of Utah Salt Lake City, Utah, United States, 84112 Less << |
NCT03106779 | Chronic Myelogenous Leukemia | Phase 3 | Recruiting | March 19, 2025 | - |
NCT00261846 | Chronic Myeloid Leukemia | PHASE2 | COMPLETED | 2015-08-06 | City of Hope National Medical ... More >>Center, Duarte, California, 91010, United States|HealthONE Presbyterian, Denver, Colorado, 80218, United States|Rocky Mountain Cancer Centers, Denver, Colorado, 80218, United States|Georgetown University Hospital, Washington, D.C., District of Columbia, 20007, United States|Emory Clinic, Atlanta, Georgia, 30322, United States|Emory University Hospital, Atlanta, Georgia, 30322, United States|Winship Cancer Institute, Atlanta, Georgia, 30322, United States|Oncology Specialists, S.C., Niles, Illinois, 60714, United States|Indiana Blood and Marrow Transplantation, Indianapolis, Indiana, 46237, United States|LSU Health Sciences Center, Shreveport, Louisiana, 71103, United States|University Of Maryland Medical Center, Baltimore, Maryland, 21201, United States|University Of Maryland, Baltimore, Maryland, 21201, United States|Roswell Park Cancer Institute, Buffalo, New York, 14263, United States|Hudson Valley Hematology and Oncology Associates, Hawthorne, New York, 10532, United States|Westchester Oncology Hematology Group, P.C., Hawthorne, New York, 10532, United States|Westchester Oncology Hematology, Group, P.C., Hawthorne, New York, 10532, United States|New York Presbyterian Hospital, New York, New York, 10021, United States|New York Presbyterian Hospital, New York, New York, 10065, United States|University of Rochester Cancer Center Pharmacy, Rochester, New York, 14642, United States|University of Rochester Medical Center Strong Memorial Hospital - James P. Wilmot Cancer Center, Rochester, New York, 14642, United States|University of Rochester Medical Center, Rochester, New York, 14642, United States|University of Rochester-James P. Wilmot Cancer Center, Rochester, New York, 14642, United States|University of Rochester, Rochester, New York, 14642, United States|Westchester Medical Center, Valhalla, New York, 10595, United States|Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania, 17033-0850, United States|MD Anderson Cancer Center, Houston, Texas, 77030-4009, United States|The University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, United States|The University of Texas, Houston, Texas, 77030, United States|Virginia Commonwealth University, Richmond, Virginia, 23298-0157, United States|Hospital Italiano de la Plata, La Plata, Provincia de Buenos Aires, 1900, Argentina|Hospital Britanico, Buenos Aires, 1280, Argentina|Academia Nacional de Medicina-Instituto de Investigaciones Hematologicas, Buenos Aires, 1425, Argentina|Instituto Medico Especializado Alexander Fleming, Buenos Aires, 1426, Argentina|Clinica del Sol, Ciudad Autonoma de Buenos Aires, C1425DQI, Argentina|Centro Medico S.A., Corrientes, 3400, Argentina|Hospital Jose Ramon Vidal, Corrientes, 3400, Argentina|Hospital universitario austral, Pcia de Buenos Aires, B1629ODT, Argentina|Royal Adelaide Hospital, Adelaide, South Australia, 5000, Australia|Institute of Medical and Veterinary Science, Adelaide, SA 5000, Australia|Department of Clinical Haematology and Bone Marrow Transplantation, Melbourne, 3181, Australia|Royal Brisbane and Women's Hospital, Queensland, 4029, Australia|Haematology and Oncology Clinics of Australia, Queensland, 4101, Australia|Klinikum Kreuzschwestern Wels, Wels, 4600, Austria|Hospital Brigadeiro da Secretaria de Estado da Saude de Sao Paulo, Jardim Paulista, Sao Paulo/sp - Brazil, CEP: 01401-901, Brazil|Centro de Estudos da Disciplina dr Hematologia da Faculdade de Medicine do ABC, Santo Andre, Sp - Brazil, CEP 09060-650, Brazil|Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Sp Brazil, 05403-000, Brazil|Hospital de Clinicas - Universidade Federal do Parana, Curitiba, PR, CEP: 80060-900, Brazil|Cross Cancer Institute, Edmonton, Alberta, T6G1Z2, Canada|BC Cancer Agency - Cancer Centre for the Southern Interior, Kelowna, British Columbia, V1Y 5L3, Canada|CancerCare Manitoba, Winnipeg, Manitoba, R3E 0V9, Canada|University Health Network Princess Margaret Hospital, Toronto, Ontario, M5G 2M9, Canada|Sir Mortimer B. Davis, Jewish General Hospital, Montreal, Quebec, H3T 1E2, Canada|Instituto Clinico Oncologico del Sur, Temuco, Chile|The First Hospital affiliated to the Medical School of Zhejiang University, Zhejiang, P.r China, 310003, China|Peking Union Medical College Hospital of Chinese Academy of Medical Sciences, Beijing, P.r. China, 100730, China|The Department of Hematology, The Chinese PLA General Hospital, Beijing, P.r. China, 100853, China|The Hematology Hospital of Chinese Academy of Medical Sciences, Tianjin, P.r. China, 300020, China|The Department of Hematology, Ruijin Hospital Affiliated to School of Medicine of Shanghai Jiaotong, Shanghai, 200025, China|Hospital Pablo Tobon Uribe, Medellin, Antioquia, 4459000, Colombia|Fundacion Santa Fe de Bogota, Bogota, Cundinamarca, Colombia|Biomedicum Helsinki, Helsinki, FIN-00029 HUS, Finland|Universitaet Mainz, Mainz, RP, 55101, Germany|University Hospital Carl Gustav Carus, Dresden, 01307, Germany|Universitaetsklinikum Hamburg - Eppendorf, Hamburg, 20246, Germany|Universitaetsklinikum Hamburg-Eppendorf, Hamburg, 20246, Germany|Universitaetsklinikum Magdeburg A. oe. R., Magdeburg, 39120, Germany|III Medizinische Klinik und Poliklinik, Mainz, 55101, Germany|Klinikum der Johann Gutenberg Universitaet Mainz, Mainz, 55131, Germany|Universitaet Mainz Iii. Medizinische Klinik Abteilung Fuer Haematologie, Mainz, D-55101, Germany|Universitaetsklinikum Mainz, Mainz, Germany|III. Medizinische Klinik, Mannheim, 68169, Germany|Pamela Youde Nethersole Eastern Hosp., Chai Wan, Hong Kong|Queen Mary Hospital, Hong Kong, Hong Kong|Fovarosi Onkormanyzat Egyesitett Szent Istvan es Szent Laszlo, Budapest, 1096, Hungary|Christian Medical College, Vellore, Tamil Nadu, 632 004, India|University of Bologna, Bologna, Province of Bologna, 40138, Italy|Azienda Ospedaliero - Universitaria San Luigi Gonzaga, Orbassano, Torino, 10043, Italy|AOU-S.Orsola-Malpighi - Universita degli Studi di Bologna, Bologna, 40138, Italy|Azienda Ospedaliera San Gerardo, Monza, 20900, Italy|The Catholic University of Korea, Seoul St. Mary Hospital, Seoul, 137-701, Korea, Republic of|Dept. of Hematology, Seoul, 138736, Korea, Republic of|Hospital Universitario "Dr. Jose Eleuterio Gonzalez", Nuevo Leon, 64460, Mexico|Centro Oncologico Estatal ISSEMYM, Toluca Estado de Mexico, CP50180, Mexico|VU University Medical Center, Amsterdam, 1081 HV, Netherlands|University Medical Center Groningen, Groningen, 9700 RB, Netherlands|UMCG - Pharmacy, Groningen, 9713 AP, Netherlands|Universitair Medisch Centrum Groningen, Groningen, 9713 GZ, Netherlands|VUMC, The Netherlands, Netherlands|Avd. for blodsykdommer, Trondheim, Norge, 7006, Norway|Hospital Nacional Edgardo Rebagliati Martins, Lima, 11, Peru|State Healthcare Institution, Sverdlovsk Regional Clinical Hospital, Ekaterinburg, 620102, Russian Federation|Kirov Research Institute of Hematology and Blood transfusion of Roszdrav Hematology clinic, Kirov, 610027, Russian Federation|Hematological Research Centre of RAMS, Moscow, 125167, Russian Federation|Moscow regional Clinical Research Institute named after M.F Vladimirsky, Moscow, 129110, Russian Federation|Rostov State Medical University of Roszdrav, Rostov-on Don, 344022, Russian Federation|Saint Petersburg State Medical University Hematology Department, Saint Petersburg, 197022, Russian Federation|Singapore General Hospital, Singapore, 169608, Singapore|University of the Free State, Bloemfontein, 9301, South Africa|University of Cape Town, Cape Town, 7925, South Africa|Johannesburg Hospital, Parktown, 2193, South Africa|Clinical Haematology Unit, Soweto, 2013, South Africa|Hospital Clinic de Barcelona (Hospital Clinic i Provincial), Barcelona, Catalonia, 08036, Spain|Hospital Universitari Clinic de Barcelona, Barcelona, Catalonia, 08036, Spain|Hospital Universitario La Princesa, Madrid, 28006, Spain|Hospital Clinico Universitario de Valencia (CHUV), Valencia, 46010, Spain|Akademiska University Hospital, Uppsala, 75185, Sweden|National Taiwan University Hospital - Section of Hematology-Oncology, Taipei 100, 10018, Taiwan|Northern Centre for Cancer Care - The Newcastle Upon Tyne Hospitals - NHS Foundation Trust, Newcastle Upon Tyne, North East England, NE7 7DN, United Kingdom|School of Clinical and Laboratory Sciences, University upon Tyne, North East England, NE1 7RU, United Kingdom|Hammersmith Hospital, London, W12 0HS, United Kingdom|Clinical Research Facility, Newcastle Upon Tyne, North East England, NE1 4LP, United Kingdom Less << |
NCT02130557 | Leukemia, Myelogenous, Chronic... More >>, Breakpoint Cluster Region-Abelson Proto-oncogene (BCR-ABL) Positive Less << | Phase 3 | Active, not recruiting | April 4, 2020 | - |
NCT02445742 | Chronic Myeloblastic Leukaemia | PHASE2 | COMPLETED | 2019-06-27 | C. H. U. de Gran Canaria Dr. N... More >>egrín, Gran Canaria, Spain|C. H. Gregorio Mara?ón, Madrid, Spain|C. U. La Paz - H. U. La Paz, Madrid, Spain|H. Ramón y Cajal, Madrid, Spain|H. U. de la Princesa, Madrid, Spain|H. U. Fundación Jiménez Díaz, Madrid, Spain|Hospital Universitario 12 de Octubre, Madrid, Spain|C. H. Regional de Málaga , H. General, Málaga, Spain|H. U. Son Espases, Palma de Mallorca, Spain|C. Asistencial U. de Salamanca, Salamanca, Spain|C. H. U. de Santiago, Santiago de Compostela, Spain|H. Virgen de la Salud, Toledo, Spain|Clínica Quirón Zaragoza S.A., Zaragoza, Spain Less << |
NCT03205267 | Chronic Myelogenous Leukaemia | Phase 2 | Recruiting | October 2019 | Germany ... More >> University Hospital Bonn Recruiting Bonn, Germany, 53127 Contact: Dominik Wolf, Prof. Dr. +49 228 287 17233 dominik.wolf@ukb.uni-bonn.de Less << |
NCT02546375 | Chronic Myeloid Leukaemia | COMPLETED | 2017-01-16 | Royal Liverpool Hospital, Live... More >>rpool, Merseyside, L7 8XP, United Kingdom|Hammersmith Hospital, London, W12 0HS, United Kingdom|Nottingham University Hospital, Nottingham, NG5 1PB, United Kingdom Less << | |
NCT01331291 | Glioblastoma | Phase 2 | Completed | - | United States, Massachusetts ... More >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Dana=Farber Cancer Institute Boston, Massachusetts, United States, 02115 Less << |
NCT01903733 | Chronic Myeloid Leukemia | Not Applicable | Active, not recruiting | April 3, 2020 | - |
NCT02782403 | Leukemia | Phase 1 Phase 2 | Recruiting | March 2021 | United States, Texas ... More >> University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact pbose@mdanderson.org Less << |
NCT02130557 | - | Active, not recruiting | - | - | |
NCT02311998 | Leukemia | Phase 1 Phase 2 | Recruiting | April 2020 | United States, Texas ... More >> University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Less << |
NCT01331291 | - | Completed | - | - | |
NCT02810990 | Chronic Myeloid Leukemia | PHASE2 | COMPLETED | 2022-06-22 | S.O.C. di Ematologia - Azienda... More >> Ospedaliera - SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy|Azienda Ospedaliero - Universitaria Ospedali Riuniti Umberto I - G.M. LANCISI - G. SALESI, Ancona, Italy|UO Ematologia con trapianto-Università degli Studi di Bari Aldo Moro, Bari, Italy|Fausto Castagnetti, Bologna, Italy|Istituto di Ematologia "Lorenzo e A. Seragnoli" - Policlinico S. Orsola - Malpighi, Bologna, Italy|ASL N.8 - Ospedale "A. Businco" - Struttura Complessa di Ematologia e CTMO, Cagliari, Italy|Università di Catania - Cattedra di Ematologia - Ospedale "Ferrarotto", Catania, Italy|S.C. Ematologia ASO S. Croce e Carle, Cuneo, Italy|Arcispedale Sant'Anna Dipartimento di Scienze Mediche Sezione di Ematologia, Ferrara, Italy|Policlinico di Careggi, Firenze, Italy|Struttura Complessa di Ematologia Ospedali Riuniti Foggia, Foggia, Italy|IRCCS_AOU San Martino-IST-Ematologia 1-Monoblocco 11°piano- lato ponente, Genova, Italy|ASL Le/1 P.O. Vito Fazzi - U.O. di Ematologia ed UTIE, Lecce, Italy|Istituto Scientifico Romagnoli per lo Studio e la Cura dei Tumori- IRST, Meldola, Italy|Policlinico G. Martino Dipartimento di Medicina Interna - U.O. Messina, Messina, Italy|Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico UOC Oncoematologia, Milano, Italy|U.O. Ematologia e Trapianto di MIdollo - Ist.Scientifico Ospedale San Raffaele, Milano, Italy|Unità Trapianto di Midollo Ist. Nazionale Tumori, Milano, Italy|Azienda Ospedaliera "S.Gerardo", Monza, Italy|Azienda Università degli Studi di Napoli "Federico II" - Facoltà di Medicina e Chirurgia, Napoli, Italy|S.C.D.U. Ematologia - Università del Piemonte Orientale Amedeo Avogadro, Novara, Italy|Dip. di Scienze Cliniche e Biologiche - Ospedale S. Luigi Gonzaga-Medicina Interna 2, Orbassano, Italy|Università degli Studi di Padova - Ematologia ed Immunologia Clinica, Padova, Italy|U.O. di Ematologia con trapianto - A.U. Policlinico "Paolo Giaccone", Palermo, Italy|Cattedra di Ematologia CTMO Università degli Studi di Parma, Parma, Italy|S.C. Ematologia - Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy|Dipartimento di Oncologia ed Ematologia - AUSL Ospedale G. da Saliceto, Piacenza, Italy|Ematologia - Ospedale San Carlo, Potenza, Italy|Dipartimento Oncologico - Ospedale S.Maria delle Croci, Ravenna, Italy|Unità Operativa Complessa di Ematologia - Arcispedale S. Maria Nuova, Reggio Emilia, Italy|Ospedale "Infermi", Rimini, Italy|U.O. di Ematologia - Centro Oncologico Basilicata, Rionero in Vulture, Italy|Complesso Ospedaliero S. Giovanni Addolorata, Roma, Italy|Divisione Ematologia - Università Campus Bio-Medico, Roma, Italy|Padiglione Cesalpino - I piano - Divisione di Ematologia - Ospedale S. Camillo, Roma, Italy|Università Cattolica del Sacro Cuore - Policlinico A. Gemelli, Roma, Italy|UOC Pronto Soccorso - Dipartimento Biotecnologie Cellulari Università di Roma "Sapienza", Roma, Italy|Istituto di Ematologia - IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy|U.O.C. Ematologia e Trapianti - A.O. Senese - Policlinico " Le Scotte", Siena, Italy|A.O. Santa Maria - Terni S.C Oncoematologia, Terni, Italy|Divisione di Ematologia - "Città della Salute e della Scienza di Torino", Torino, Italy|S.C. Ematologia 2 A.O. Città della Salute e della Scienza di Torino San Giovanni Battista, Torino, Italy|Clinica Ematologica-Centro Trapianti e Terapie cellulari, Udine, Italy|Medicina Interna I - Ospedale di Circolo, Varese, Italy|A. O. - Istituti Ospitalieri di Verona- Div. di Ematologia - Policlinico G.B. Rossi, Verona, Italy Less << |
NCT03023319 | Carcinoma, Non-Small-Cell Lung... More >> Mesothelioma Bladder Cancer Ovarian Cancer Peritoneal Cancer Thymoma Thymus Cancer Uterine Cervical Cancer Less << | Phase 1 | Recruiting | July 2020 | United States, Ohio ... More >> UC Health Recruiting Cincinnati, Ohio, United States, 45219 Contact: UCCI Clinical Trials Office 513-584-7698 kastla@ucmail.uc.edu Less << |
NCT02546375 | Chronic Myeloid Leukaemia | COMPLETED | 2017-01-16 | Royal Liverpool Hospital, Live... More >>rpool, Merseyside, L7 8XP, United Kingdom|Hammersmith Hospital, London, W12 0HS, United Kingdom|Nottingham University Hospital, Nottingham, NG5 1PB, United Kingdom Less << | |
NCT03128411 | Leukemia, Chronic Myelogenous | PHASE2 | COMPLETED | 2021-03-04 | Fujita Health University Hospi... More >>tal, Toyoake-City, Aichi, 470-1192, Japan|Toyohashi Municipal Hospital, Toyohashi, Aichi, 441-8570, Japan|Akita University Hospital, Akita City, Akita, 010-8543, Japan|Japanese Red Cross Narita Hospital, Narita, Chiba, 286-8523, Japan|Ehime University Hospital, Toon-shi, Ehime, 791-0295, Japan|Kobe City Medical Center General Hospital, Kobe-city, Hyogo, 650-0047, Japan|Ishikawa Prefectural Central Hospital, Kanazawa, Ishikawa, 920-8530, Japan|Yokohama City University Medical Center, Yokohama, Kanagawa, 232-0024, Japan|National Hospital Organization Osaka Minami Medical Center, Kawachinagano, Osaka, 586-8521, Japan|Osaka City University Hospital, Osaka-City, Osaka, 545-8586, Japan|Kindai University Hospital, Osaka-Sayama, Osaka, 589-8511, Japan|Hamamatsu University Hospital, Hamamatsu, Shizuoka, 431-3192, Japan|Juntendo University Hospital, Bunkyo-ku, Tokyo, 113-8431, Japan|Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital, Bunkyo-ku, Tokyo, 113-8677, Japan|NTT Medical Center Tokyo, Shinagawa-ku, Tokyo, 141-8625, Japan|National Hospital Organization Disaster Medical Center, Tachikawa, Tokyo, 190-0014, Japan|Yamagata University Hospital, Yamagata-Shi, Yamagata, 990-9585, Japan|Chiba University Hospital, Chiba, 260-8677, Japan|National Hospital Organization Kyushu Cancer Center, Fukuoka, 811-1395, Japan|Saga University Hospital, Saga, 849-8501, Japan|Nippon Medical School Hospital, Tokyo, 113-8603, Japan Less << |
NCT02906696 | Chronic Myelogenous Leukemia | Phase 2 | Recruiting | October 2022 | United States, Texas ... More >> University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Less << |
NCT04258943 | Philadelphia Chromosome Positi... More >>ve CML|Accelerated Phase Chronic Myelogenous Leukemia|Blastic Phase Chronic Myelogenous Leukemia|Chronic Phase Chronic Myelogenous Leukemia Less << | PHASE1|PHASE2 | ACTIVE_NOT_RECRUITING | 2025-07-28 | Children's Hospital of Alabama... More >>, Birmingham, Alabama, 35233, United States|Phoenix Childrens Hospital, Phoenix, Arizona, 85016, United States|Arkansas Children's Hospital, Little Rock, Arkansas, 72202-3591, United States|Kaiser Permanente Downey Medical Center, Downey, California, 90242, United States|Loma Linda University Medical Center, Loma Linda, California, 92354, United States|Kaiser Permanene-Oakland, Oakland, California, 94611, United States|Children's Hospital of Orange County, Orange, California, 92868, United States|Lucile Packard Children's Hospital Stanford University, Palo Alto, California, 94304, United States|Alfred I duPont Hospital for Children, Wilmington, Delaware, 19803, United States|Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida, 33908, United States|University of Florida Health Science Center - Gainesville, Gainesville, Florida, 32610, United States|Nemours Children's Hospital, Orlando, Florida, 32827, United States|Kapiolani Medical Center for Women and Children, Honolulu, Hawaii, 96826, United States|Riley Hospital for Children, Indianapolis, Indiana, 46202, United States|Blank Children's Hospital, Des Moines, Iowa, 50309, United States|Norton Children's Hospital, Louisville, Kentucky, 40202, United States|Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland, 21287, United States|Dana-Farber/Harvard Cancer Center, Boston, Massachusetts, 02215, United States|Children's Mercy Hospitals and Clinics, Kansas City, Missouri, 64108, United States|Children's Specialty Center of Nevada II, Las Vegas, Nevada, 89109, United States|Hackensack University Medical Center, Hackensack, New Jersey, 07601, United States|Morristown Medical Center, Morristown, New Jersey, 07960, United States|Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey, 08903, United States|Roswell Park Cancer Institute, Buffalo, New York, 14263, United States|The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York, 11040, United States|Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina, 28203, United States|Children's Hospital Medical Center of Akron, Akron, Ohio, 44308, United States|Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229, United States|Rainbow Babies and Childrens Hospital, Cleveland, Ohio, 44106, United States|Nationwide Children's Hospital, Columbus, Ohio, 43205, United States|Lehigh Valley Hospital-Cedar Crest, Bethlehem, Pennsylvania, 18017, United States|Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104, United States|Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, 15224, United States|Rhode Island Hospital, Providence, Rhode Island, 02903, United States|East Tennessee Childrens Hospital, Knoxville, Tennessee, 37916, United States|Saint Jude Children's Research Hospital, Memphis, Tennessee, 38105, United States|Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee, 37232, United States|Dell Children's Medical Center of Central Texas, Austin, Texas, 78723, United States|UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas, 75390, United States|Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas, 77030, United States|M D Anderson Cancer Center, Houston, Texas, 77030, United States|Inova Fairfax Hospital, Falls Church, Virginia, 22042, United States|Children's Hospital of The King's Daughters, Norfolk, Virginia, 23507, United States|Seattle Children's Hospital, Seattle, Washington, 98105, United States|Children's Hospital of Wisconsin, Milwaukee, Wisconsin, 53226, United States Less << |
NCT05363488 | Myeloid Leukemia | COMPLETED | 2021-10-08 | eatson West of Scotland Cancer... More >> Centre, Glasgow, United Kingdom Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
1.89mL 0.38mL 0.19mL |
9.43mL 1.89mL 0.94mL |
18.85mL 3.77mL 1.89mL |