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Bis-NH2-PEG2 is a 2-unit PEG derivative with two amino groups. It is commonly used in peptide synthesis and in bioconjugation processes.

4.5 *For Research Use Only !

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Quality Control of Bis-NH2-PEG2 Purity: 98% SDS Specification

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Product Details of Bis-NH2-PEG2

CAS No. :	929-59-9
Formula :	C₆H₁₆N₂O₂
M.W :	148.20
SMILES Code :	NCCOCCOCCN
MDL No. :	MFCD00040474
InChI Key :	IWBOPFCKHIJFMS-UHFFFAOYSA-N
Pubchem ID :	70248

Safety of Bis-NH2-PEG2

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H302-H314-H317
Precautionary Statements:	P280-P264-P270-P271-P272-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P403+P233-P501
Class:	8
UN#:	2735
Packing Group:	Ⅱ

Application In Synthesis of Bis-NH2-PEG2

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 929-59-9 ]

[ 929-59-9 ] Synthesis Path-Downstream 1~25

1
[ 929-59-9 ]
[ 120550-35-8 ]
[ 138529-46-1 ]

References: [1]Organic and biomolecular chemistry,2003,vol. 1,p. 950 - 959.
[2]Biomacromolecules,2012,vol. 13,p. 2831 - 2842.

2
[ 3123-97-5 ]
[ 929-59-9 ]
[ 533932-20-6 ]

References: [1]Nucleosides, nucleotides and nucleic acids,2003,vol. 22,p. 703 - 705.

3
[ 929-59-9 ]
[ 6345-43-3 ]
6,9-dioxa-3,12,15,17-tetraazabicyclo[12.3.1]octadeca-1⁽¹⁸⁾,14,16-triene-2,13-dione [ No CAS ]
6,9,23,26-tetraoxa-3,12,15,17,20,29,32,34-octaazatricyclo[29.3.1.1^14,18]hexatriaconta-1⁽³⁵⁾,14,16,18⁽³⁶⁾,31,33-hexaene-2,13,19,30-tetraone [ No CAS ]

References: [1]Helvetica Chimica Acta,2004,vol. 87,p. 156 - 166.

4
[ 929-59-9 ]
[ 25309-39-1 ]
methyl 2,13-dioxo-6,9-dioxa-3,12,18-triazabicyclo[12.3.1]octadeca-1⁽¹⁸⁾,14,16-triene-16-carboxylate [ No CAS ]

References: [1]Helvetica Chimica Acta,2004,vol. 87,p. 156 - 166.

5
[ 929-59-9 ]
[ 37091-73-9 ]
1-(1,3-dimethylimidazolidin-2-ylideneamino)-2-{2-[2-(1,3-dimethylimidazolidin-2-ylideneamino)ethoxy]ethoxy}ethane [ No CAS ]

References: [1]European Journal of Organic Chemistry,2005,p. 4879 - 4890.

6
[ 929-59-9 ]
[ 63521-92-6 ]
C₁₁H₂₂N₂O₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
45%	In acetonitrile; at 25℃;	Synthesis and Characterization of Pent-4-enoi? Acid {2-[2-(2-Pent-4-Ylnoylamino-Ethoxy)-Ethoxy] -Ethyl} -Amide (1); PfI]1T.?.? 4-pentynoic acid anhydride NHS ester [00143] Pentenoic anhydride (789 mg, 4.3 mmol, 1.0 equiv.) in acetonitrile (10 mL) was added dropwise over the course of 30 min to a stirring solution of 2,2'- (ethylenedioxy)bis-(ettiylamine) (640 mg, 4.3 mmol, 1.0 equiv.) in 20 mL acetonitrile at 25 C. At the conclusion of addition the reaction solution was dried in vacuo. The dried material was dissolved in 50 mM acetic acid in H2O (20 mL) and purified by preparative HPLC (acetonitrile/50 mM aqueous acetic acid gradient) followed by lyophilization to afford the acetate salt of the monoacylated material (560 nxg, 45%) as a pale yellow oil. To trie monoacylated material (300 mg, 1.0 mmol, 1.0 equiv.) in acetonitrile (20 mL) was added N-hydroxysuccinirnide activated 4-pentynoic acid (220 mg, 1.1 mmol, 1.1 equiv.) and the resulting clear solution was allowed to stir under N2 atmosphere at 25 0C for 20 min. The reaction was dried in vacuo, and the material was resuspended in H2O (2OmL) and purified via preparative HPLC (acetonitrile/water gradient). Lyophilization afforded 1 (230 mg, 741^o, 33% overall) as an off-Lambdavhite crystalline solid.[00144] 1H-NMH (500 MHz, CDCl3): delta 6.20 (br, s, IH, NHCO), delta 6.01 (br, s,IH, NHCO), delta 5.86-5.78 (m, IH, CHCH2), delta 5.06 (dd, IH3 J = 1.5, 17.0 Hz, CHCH2), delta 4.99 (dd, IH,[00145] J = 1.5, 10.0 Hz, CHCH2), delta 3.60 (s, 4H, OCH2CH2O), delta 3.55 (m, 4H,CHOCH2), delta 3.47 (m, 4H5 CH2NH), delta 2.52 (m, 2H, CH2CCH), delta 2.44-2.36 (m, 4H, CH2CHCH2, NHCOCH2), delta 2.28 (t, 2H, NHCOCH2), delta 2.00 (t, IH, CCH). EPO <DP n="61"/>[00146] 13C-NMR (100 MHz, CDCl3): delta 175, 174, 137.3, 115.8, 83.2, 70.5, 70.4,70.2, 70.1, 69.5, 39.5, 39.4, 36.0, 35.5, 29.8, 15.1.[00147] HRMS (TOF ES+) calculated fotau C16H26N2O4 (M+H)+ = 311.1972; observed = 311.1989.

References: [1]Patent: WO2007/8226,2007,A2 .Location in patent: Page/Page column 59-60.

7
dysprosium(III) nitrate hydrate [ No CAS ]
gadolinium nitrate hydrate [ No CAS ]
[ 929-59-9 ]
[ 32596-43-3 ]
DyGd(C₆H₂O(Cl)(CHNC₂H₄OC₂H₄OC₂H₄NCH))2(NO₃)4*2H₂O [ No CAS ]