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Chemical Structure| 2851885-95-3 Chemical Structure| 2851885-95-3

Structure of ARV-393
CAS No.: 2851885-95-3

Chemical Structure| 2851885-95-3

ARV-393

CAS No.: 2851885-95-3

ARV-393 is an orally active PROTAC that utilizes the ubiquitin-proteasome system to target the degradation of BCL6. ARV-393 consists of ligand conjugates targeting BCL6 and the E3 ligase cereblon

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Cat. No.: A2698981 Purity: 99%

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Product Details of ARV-393

CAS No. :2851885-95-3
Formula : C46H53ClFN9O7
M.W : 898.42
SMILES Code : FC1=C2C(C(N(C3C(NC(CC3)=O)=O)C2)=O)=CC=C1C4CCN([C@@H]5C[C@H](C5)OC6CCN(C7=NC=C(Cl)C(NC8=CC=C(N(C(C(OCC(NC)=O)=C9)=O)C(C)C)C9=C8)=N7)CC6)CC4
MDL No. :N/A

Safety of ARV-393

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT06393738 Relapsed/Refractory (R/R) Matu... More >>re B Cell Non Hodgkin Lymphoma (NHL)|Relapsed/Refractory (R/R) Angioimmunoblastic T-cell Lymphoma (AITL) Less << PHASE1 RECRUITING 2025-12-25 Clinical Trial Site, New Haven... More >>, Connecticut, 06510, United States|Clinical Trial Site, Detroit, Michigan, 48201, United States|Clinical Trial Site, New Brunswick, New Jersey, 10065, United States|Clinical Trial Site, New York, New York, 10016, United States|Clinical Trial Site, Cleveland, Ohio, 44122, United States|Clinical Trial Site, Nashville, Tennessee, 37203, United States|Clinical Trial Site, Houston, Texas, 77030, United States|Clinical Trial Site, Toronto, Ontario, M5G 1Z5, Canada|Clinical Trial Site, Montreal, Quebec, H3T 1E2, Canada|Clinical Trial Site, Copenhagen, 2100, Denmark|Clinical Trial Site, Odense C, 5000, Denmark|Clinical Trial Site, El Palmar, Murcia, 30120, Spain|Clinical Trial Site, Pamplona, Navarra, 31008, Spain|Clinical Trial Site, Barcelona, 8908, Spain|Clinical Trial Site, Madrid, 28050, Spain Less <<

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1 mM

5 mM

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1.11mL

0.22mL

0.11mL

5.57mL

1.11mL

0.56mL

11.13mL

2.23mL

1.11mL

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