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Chemical Structure| 1196723-93-9 Chemical Structure| 1196723-93-9

Structure of HSF1A
CAS No.: 1196723-93-9

Chemical Structure| 1196723-93-9

HSF1A

CAS No.: 1196723-93-9

HSF1A is an activator of Heat shock transcription factor 1 (HSF1).

4.5 *For Research Use Only !

Cat. No.: A327751 Purity: 99%

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Product Details of HSF1A

CAS No. :1196723-93-9
Formula : C21H19N3O2S2
M.W : 409.52
SMILES Code : O=S(C1=CC=C(CC)C=C1)(NC2=CC(C3=CC=CS3)=NN2C4=CC=CC=C4)=O
MDL No. :MFCD22580417
InChI Key :KJTITGSAONQVPY-UHFFFAOYSA-N
Pubchem ID :44472508

Safety of HSF1A

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Mouse embryonic fibroblasts (MEFs) 50 μM HSF1A provided similar protection against TcdB as observed in HeLa cells Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9580-9585
HeLa cells 50 μM 90 minutes HSF1A blocked TcdB-induced cytotoxicity in a concentration-dependent manner, with 50 μM completely blocking it Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9580-9585
Primary neonatal rat ventricular myocytes (NRVMs) 10 μM 24 hours HSF1A significantly enhanced the ability of CHIP-ΔM/U to inhibit IGF-IIR expression, reduce caspase-3 activation and retained cell viability. Cell Death Dis. 2016 Nov 3;7(11):e2455
H9c2 cells 10 μM 24 hours HSF1A significantly inhibited DOX-induced IGF-IIR upregulation, caspase-3 cleavage and caspase-3 activity. Cell Death Dis. 2016 Nov 3;7(11):e2455
A549 cells 200 µM 4 hours To evaluate the protective effects of HSF1A against PT-induced cell intoxication in A549 cells. Results showed that HSF1A also effectively reduced PT intoxication in A549 cells. Toxins (Basel). 2024 Jan 10;16(1):36
CHO cells 200 µM 4 hours To evaluate the protective effects of HSF1A against PT-induced cell intoxication. Results showed that HSF1A effectively reduced the levels of ADP-ribosylated Gαi in PT-treated cells. Toxins (Basel). 2024 Jan 10;16(1):36

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Wistar Kyoto rats (WKY) DOX-induced cardiomyopathy model Intraperitoneal injection 100 mg/kg/day Once daily for 6 weeks HSF1A significantly alleviated DOX-induced cardiac dysfunction and minimized cardiac damage, reducing TUNEL-positive cardiomyocytes. Cell Death Dis. 2016 Nov 3;7(11):e2455

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.44mL

0.49mL

0.24mL

12.21mL

2.44mL

1.22mL

24.42mL

4.88mL

2.44mL

 

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