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Chemical Structure| 7781-98-8 Chemical Structure| 7781-98-8
Chemical Structure| 7781-98-8

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Product Details of Ethyl 3-hydroxybenzoate

CAS No. :7781-98-8
Formula : C9H10O3
M.W : 166.17
SMILES Code : O=C(OCC)C1=CC=CC(O)=C1
MDL No. :MFCD00002296
InChI Key :MWSMNBYIEBRXAL-UHFFFAOYSA-N
Pubchem ID :24522

Safety of Ethyl 3-hydroxybenzoate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H335
Precautionary Statements:P261

Application In Synthesis of Ethyl 3-hydroxybenzoate

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 7781-98-8 ]

[ 7781-98-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 7781-98-8 ]
  • [ 99337-98-1 ]
  • cis-3-[4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)cyclohexyloxy]benzoic acid ethyl ester [ No CAS ]
  • 2
  • [ 31865-25-5 ]
  • [ 7781-98-8 ]
  • [ 74-88-4 ]
  • benzyl trans-3-(3-(ethoxycarbonyl)phenoxy)-4-methoxypyrrolidine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
32.2 g A mixture of <strong>[31865-25-5]benzyl 6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate</strong> (19.5 g), ethyl 3-hydroxybenzoate (22.2 g), cesium carbonate (72.5 g) and DMF (150 ml) was stirred overnight at 80 C. To the reaction solution were added iodomethane (37.9 g) and 60% sodium hydride (7.11 g) at 0 C., and the mixture was stirred under nitrogen atmosphere at room temperature for 1 hr. The mixture was poured into ice water, and extracted with ethyl acetate. The organic layer was separated, washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give benzyl trans-3-(3-(ethoxycarbonyl)phenoxy)-4-methoxypyrrolidine-1-carboxylate (32.2 g). To a mixture of the obtained benzyl trans-3-(3-(ethoxycarbonyl)phenoxy)-4-methoxypyrrolidine-1-carboxylate (11.7 g) and THF (100 ml) was added lithium tetrahydroborate (2.48 g) by small and small at room temperature. The mixture was stirred at 50 C. for 7 hr. To the mixture was added saturated aqueous ammonium chloride solution at 0 C., and the mixture was extracted with ethyl acetate. The organic layer was separated, washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (10.0 g).
 

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