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Chemical Structure| 505-56-6 Chemical Structure| 505-56-6
Chemical Structure| 505-56-6

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Docosanedioic acid is a non-degradable ADC linker for the synthesis of antibody-drug conjugates (ADCs) and also serves as an alkyl chain-based PROTAC linker for PROTAC synthesis.

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Product Details of Docosanedioic acid

CAS No. :505-56-6
Formula : C22H42O4
M.W : 370.57
SMILES Code : O=C(O)CCCCCCCCCCCCCCCCCCCCC(O)=O
MDL No. :MFCD00002806
InChI Key :DGXRZJSPDXZJFG-UHFFFAOYSA-N
Pubchem ID :244872

Safety of Docosanedioic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Docosanedioic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 505-56-6 ]

[ 505-56-6 ] Synthesis Path-Downstream   1~1

  • 1
  • suberin [ No CAS ]
  • [ 4494-16-0 ]
  • [ 3329-38-2 ]
  • C17H32O4 [ No CAS ]
  • [ 69232-68-4 ]
  • [ 506-45-6 ]
  • [ 496-86-6 ]
  • [ 505-56-6 ]
YieldReaction ConditionsOperation in experiment
Air-dried bark was cut in strips, granulated and ground to give a powder having particles of 20 mesh, followed by extraction of said powder for 24 hours with aceton in a Soxhlet apparatus. The remaining solid material was filtered and dried. The solid material (100 g) was refluxed in basic 2-propanol (22 g/0.55 mol NaOH in 1 liter of alcohol) for 1 hour. The solid material was filtered from the solution while still hot. The solution was still refluxed for 15 min. The solution was kept in a freezer at least 24 hours. The precipitate was filtered and dried. The product containing sodium salts of carboxylic acids of suberin was a yellowish powder. EPO <DP n="19"/>Example 2Preparation of suberin acidsThe hydrolysis product of suberin (6 g) obtained in Example 1 was dissolved in water (750 ml) in a bath at about 100 C, followed by cooling the solution. 0.25 M sulphuric acid was added to the solution to adjust the pH of the solution between 2 and 3. The mixture was extracted with diethyl ether (400 + 200 + 200 ml) and dried with sodium sulphate. The solvent was removed by means of a rotary evaporator, followed by drying of the product in vacuum at room temperature. The product contained fatty acids of suberin, the yield thereof being between 84 and 90 %. The product was a yellowish powder.1H NMR (ppm): 1.0-1.6(m) CH2; 2.0 CH2; 2.2(t) CH2CO2; 2.8 CH(O)CH; 3.2 CH(OH)CH(OH); 3.4(t) CH2OH; 3.8 CH(OH); 4.0, 4.2 OH; 5.3 CH=CH; 11.8 OH 13C NMR (ppm): 24-28(5s) CH2; 29(m), 32 CH2; 34 CH2COOH; 37 CH2CH(OH); 56 CH(O)CH; 61 CH2OH; 70 CH(OH); 73 CH(OH)CH(OH); 130 CH=CH; 174 COOHContents of Fatty acid content of suberin is shown in Table 4, by NMR analysis.Table 4. Fatty acids of suberin
 

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