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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 58142-99-7 Chemical Structure| 58142-99-7

Structure of DSRM-3716
CAS No.: 58142-99-7

Chemical Structure| 58142-99-7

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DSRM-3716 is a potent, reversible inhibitor of SARM1 NAD(+) hydrolase (IC50 = 75 nM).

Synonyms: 5-Iodoisoquinoline

4.5 *For Research Use Only !

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Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

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Product Citations

Product Citations

Bratkowski, Matthew ; Burdett, Thomas C. ; Danao, Jean ; Wang, Xidao ; Mathur, Prakhyat ; Gu, Weijing , et al.

Abstract: Axon degeneration is an early pathological event in many neurological diseases. The identification of the nicotinamide adenine dinucleotide (NAD) hydrolase SARM1 as a central metabolic sensor and axon executioner presents an exciting opportunity to develop novel neuroprotective therapies that can prevent or halt the degenerative process, yet limited progress has been made on advancing efficacious inhibitors. We describe a class of NAD-dependent active-site SARM1 inhibitors that function by intercepting NAD hydrolysis and undergoing covalent conjugation with the reaction product adenosine diphosphate ribose (ADPR). The resulting small-molecule ADPR adducts are highly potent and confer compelling neuroprotection in preclinical models of neurological injury and disease, validating this mode of inhibition as a viable therapeutic strategy. Additionally, we show that the most potent inhibitor of CD38, a related NAD hydrolase, also functions by the same mechanism, further underscoring the broader applicability of this mechanism in developing therapies against this class of enzymes.

Keywords: NAD hydrolase ; SARM1 ; axon degeneration ; neurodegenerative disease ; neurofilament light ; neuroprotection ; small-molecule inhibitor ; uncompetitive inhibition

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Product Details of DSRM-3716

CAS No. :58142-99-7
Formula : C9H6IN
M.W : 255.06
SMILES Code : IC1=CC=CC2=C1C=CN=C2
Synonyms :
5-Iodoisoquinoline
MDL No. :MFCD11226893
InChI Key :CUILFTFMBBGSFT-UHFFFAOYSA-N
Pubchem ID :11391181

Safety of DSRM-3716

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H311-H315-H319-H412
Precautionary Statements:P264-P270-P273-P280-P301+P312+P330-P302+P352+P312-P305+P351+P338-P332+P313-P337+P313-P405-P501
Class:6.1
UN#:2811
Packing Group:

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.92mL

0.78mL

0.39mL

19.60mL

3.92mL

1.96mL

39.21mL

7.84mL

3.92mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
 

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