98-68-0|4-Methoxybenzene-1-sulfonyl chloride| Ambeed

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

Structure of 98-68-0

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

{[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

Quality Control of [ 98-68-0 ] Purity: 98% SDS Specification

COA

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

NMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

CNMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

HPLC

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

LC-MS

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

1-2 Day Shipping
High Quality
Technical Support

Product Details of [ 98-68-0 ]

CAS No. :	98-68-0
Formula :	C₇H₇ClO₃S
M.W :	206.65
SMILES Code :	O=S(C1=CC=C(OC)C=C1)(Cl)=O
MDL No. :	MFCD00007446
InChI Key :	DTJVECUKADWGMO-UHFFFAOYSA-N
Pubchem ID :	7401

Safety of [ 98-68-0 ]

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H314-H290
Precautionary Statements:	P260-P280-P303+P361+P353-P301+P330+P331-P304+P340+P310-P305+P351+P338+P310
Class:	8
UN#:	3261
Packing Group:	Ⅱ

Computational Chemistry of [ 98-68-0 ] Show Less

Physicochemical Properties

Num. heavy atoms	12
Num. arom. heavy atoms	6
Fraction Csp3	0.14
Num. rotatable bonds	2
Num. H-bond acceptors	3.0
Num. H-bond donors	0.0
Molar Refractivity	46.02
TPSA ? Topological Polar Surface Area: Calculated from Ertl P. et al. 2000 J. Med. Chem.	51.75 Å²

Lipophilicity

Log P_o/w (iLOGP)? iLOGP: in-house physics-based method implemented from Daina A et al. 2014 J. Chem. Inf. Model.	1.89
Log P_o/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by XLOGP program, version 3.2.2, courtesy of CCBG, Shanghai Institute of Organic Chemistry	1.54
Log P_o/w (WLOGP)? WLOGP: Atomistic method implemented from Wildman SA and Crippen GM. 1999 J. Chem. Inf. Model.	2.7
Log P_o/w (MLOGP)? MLOGP: Topological method implemented from Moriguchi I. et al. 1992 Chem. Pharm. Bull. Moriguchi I. et al. 1994 Chem. Pharm. Bull. Lipinski PA. et al. 2001 Adv. Drug. Deliv. Rev.	1.23
Log P_o/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	1.31
Consensus Log P_o/w? Consensus Log P_o/w: Average of all five predictions	1.74

Water Solubility

Log S (ESOL):? ESOL: Topological method implemented from Delaney JS. 2004 J. Chem. Inf. Model.	-2.33
Solubility	0.968 mg/ml ; 0.00468 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble
Log S (Ali)? Ali: Topological method implemented from Ali J. et al. 2012 J. Chem. Inf. Model.	-2.24
Solubility	1.2 mg/ml ; 0.00581 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	-3.07
Solubility	0.175 mg/ml ; 0.000847 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble

Pharmacokinetics

GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg	High
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg	Yes
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) and tested on 415 molecules (test set) 10-fold CV: ACC=0.72 / AUC=0.77 External: ACC=0.88 / AUC=0.94	No
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.83 / AUC=0.90 External: ACC=0.84 / AUC=0.91	Yes
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.80 / AUC=0.86 External: ACC=0.80 / AUC=0.87	No
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) and tested on 2075 molecules (test set) 10-fold CV: ACC=0.78 / AUC=0.85 External: ACC=0.71 / AUC=0.81	No
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) and tested on 1068 molecules (test set) 10-fold CV: ACC=0.79 / AUC=0.85 External: ACC=0.81 / AUC=0.87	No
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) and tested on 2579 molecules (test set) 10-fold CV: ACC=0.77 / AUC=0.85 External: ACC=0.78 / AUC=0.86	No
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from Potts RO and Guy RH. 1992 Pharm. Res.	-6.47 cm/s

Druglikeness

Lipinski? Lipinski (Pfizer) filter: implemented from Lipinski CA. et al. 2001 Adv. Drug Deliv. Rev. MW ≤ 500 MLOGP ≤ 4.15 N or O ≤ 10 NH or OH ≤ 5	0.0
Ghose? Ghose filter: implemented from Ghose AK. et al. 1999 J. Comb. Chem. 160 ≤ MW ≤ 480 -0.4 ≤ WLOGP ≤ 5.6 40 ≤ MR ≤ 130 20 ≤ atoms ≤ 70	None
Veber? Veber (GSK) filter: implemented from Veber DF. et al. 2002 J. Med. Chem. Rotatable bonds ≤ 10 TPSA ≤ 140	0.0
Egan? Egan (Pharmacia) filter: implemented from Egan WJ. et al. 2000 J. Med. Chem. WLOGP ≤ 5.88 TPSA ≤ 131.6	0.0
Muegge? Muegge (Bayer) filter: implemented from Muegge I. et al. 2001 J. Med. Chem. 200 ≤ MW ≤ 600 -2 ≤ XLOGP ≤ 5 TPSA ≤ 150 Num. rings ≤ 7 Num. carbon > 4 Num. heteroatoms > 1 Num. rotatable bonds ≤ 15 H-bond acc. ≤ 10 H-bond don. ≤ 5	0.0
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat implemented from Martin YC. 2005 J. Med. Chem.	0.55

Medicinal Chemistry

PAINS? Pan Assay Interference Structures: implemented from Baell JB. & Holloway GA. 2010 J. Med. Chem.	0.0 alert
Brenk? Structural Alert: implemented from Brenk R. et al. 2008 ChemMedChem	0.0 alert: heavy_metal
Leadlikeness? Leadlikeness: implemented from Teague SJ. 1999 Angew. Chem. Int. Ed. 250 ≤ MW ≤ 350 XLOGP ≤ 3.5 Num. rotatable bonds ≤ 7	No; 1 violation:MW<1.0
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) based on 1024 fragmental contributions (FP2) modulated by size and complexity penaties, trained on 12'782'590 molecules and tested on 40 external molecules (r² = 0.94)	1.66

Application In Synthesis of [ 98-68-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 98-68-0 ]
Downstream synthetic route of [ 98-68-0 ]

[ 98-68-0 ] Synthesis Path-Upstream 1~1

1
[ 78750-68-2 ]
[ 98-68-0 ]
[ 141430-65-1 ]

References: [1] Journal of Medicinal Chemistry, 1992, vol. 35, # 13, p. 2496 - 2497.
[2] Patent: WO2006/76511, 2006, A1, . Location in patent: Page/Page column 16.
[3] Patent: WO2006/76630, 2006, A1, . Location in patent: Page/Page column 14.
[4] Patent: US2006/293367, 2006, A1, . Location in patent: Page/Page column 2.

[ 98-68-0 ] Synthesis Path-Downstream 1~30

1
[ 5760-20-3 ]
[ 98-68-0 ]
4-Methoxy-N-quinolin-2-ylmethyl-benzenesulfonamide [ No CAS ]

References: [1]Journal of Medicinal Chemistry,1997,vol. 40,p. 2525 - 2532.

2
[ 33105-81-6 ]
[ 98-68-0 ]
2-(4-Methoxy-benzenesulfonylamino)-3,3-dimethyl-butyric acid [ No CAS ]

References: [1]Journal of Medicinal Chemistry,1997,vol. 40,p. 2525 - 2532.

3
[ 98-68-0 ]
[ 88319-43-1 ]
[ 1026472-43-4 ]

References: [1]Journal of Medicinal Chemistry,1997,vol. 40,p. 2525 - 2532.

4
[ 98-68-0 ]
[ 117810-52-3 ]
2-(4-methoxy-benzenesulfonyl)-hexahydro-pyrrolo[1,2-<i>a</i>]pyrazin-6-one [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2000,vol. 43,p. 1969 - 1974.

5
[ 15980-22-0 ]
[ 98-68-0 ]
<i>N</i>-(4-hydroxy-3,5-dimethyl-phenyl)-4-methoxy-benzenesulfonamide [ No CAS ]

References: [1]Russian Journal of Organic Chemistry,2000,vol. 36,p. 522 - 527.

6
[ 98-00-0 ]
[ 135112-28-6 ]
[ 98-68-0 ]
[ 160885-98-3 ]
N-(2-furfuryl)-N-(4-methoxybenzenesulfonyl)-L-norvalinyl-L-valinol [ No CAS ]

References: [1]Journal of Organic Chemistry,2000,vol. 65,p. 5048 - 5056.

7
[ 636-72-6 ]
[ 135112-28-6 ]
[ 98-68-0 ]
[ 160885-98-3 ]
N-(2-thienylmethyl)-N-(4-methoxybenzenesulfonyl)-L-norvalinyl-L-valinol [ No CAS ]

References: [1]Journal of Organic Chemistry,2000,vol. 65,p. 5048 - 5056.

8
[ 624-95-3 ]
[ 135112-28-6 ]
[ 98-68-0 ]
[ 160885-98-3 ]
N-(3,3-dimethylbutyl)-N-(4-methoxybenzenesulfonyl)-L-norvalinyl-L-valinol [ No CAS ]

References: [1]Journal of Organic Chemistry,2000,vol. 65,p. 5048 - 5056.

9
[ 135112-28-6 ]
[ 98-68-0 ]
[ 160885-98-3 ]
[ 100-51-6 ]
N-benzyl-N-(4-methoxybenzenesulfonyl)-L-norvalinyl-L-valinol [ No CAS ]

References: [1]Journal of Organic Chemistry,2000,vol. 65,p. 5048 - 5056.

10
[ 17672-21-8 ]
[ 98-68-0 ]
[ 206547-14-0 ]

Yield	Reaction Conditions	Operation in experiment
0.86 g (57%)	In pyridine;	EXAMPLE 31 3-Hydroxy-2-(4-methoxy-benzenesulfonylamino)-benzoic acid methyl ester To a solution of 0.748 g (4.48 mmol) of the product of Example 30 in 10.0 mL of pyridine was added 0.928 g (4.48 mmol) of p-methoxybenzenesulfonyl chloride. The reaction mixture was stirred for 24 h at room temperature and then diluted with chloroform and washed with 5% HCl solution and water. The organic layer was then dried over MgSO4, filtered and concentrated in vacuo. The residue was triturated with ether-hexanes and the resulting solid was filtered and dried to provide 0.86 g (57%) of the desired product as a tan solid. Electrospray Mass Spec: 338.2 (M+H)+
0.86g (57%)	In pyridine;	Example 31 3-Hydroxy-2-(4-methoxy-benzenesulfonylamino)-benzoic acid methyl ester To a solution of 0.748g (4.48mmol) of the product of Example 30 in 10.0mL of pyridine was added 0.928g (4.48mmol) of p-methoxybenzenesulfonyl chloride. The reaction mixture was stirred for 24h at room temperature and then diluted with chloroform and washed with 5% HCl solution and water. The organic layer was then dried over MgSO4, filtered and concentrated in vacuo. The residue was triturated with ether-hexanes and the resulting solid was filtered and dried to provide 0.86g (57%) of the desired product as a tan solid. Electrospray Mass Spec: 338.2 (M+H)+

References: [1]Bioorganic and medicinal chemistry letters,2001,vol. 11,p. 235 - 238.
[2]Patent: US5929097,1999,A .
[3]Patent: EP938471,2001,B1 .

11
[ 98-68-0 ]
[ 121148-00-3 ]
[ 121148-19-4 ]

References: [1]Bioorganic and Medicinal Chemistry,2002,vol. 10,p. 1399 - 1415.

12
[ 74209-34-0 ]
[ 64-17-5 ]
[ 98-68-0 ]
N-(3-bromo-1H-7-indazolyl)-4-methoxybenzenesulfonamide [ No CAS ]
N-(3-bromo-4-ethoxy-1H-7-indazolyl)-4-methoxybenzenesulfonamide [ No CAS ]

References: [1]Tetrahedron,2005,vol. 61,p. 8218 - 8225.
[2]Synthetic Communications,2011,vol. 41,p. 999 - 1005.

13
[ 135112-28-6 ]
[ 98-68-0 ]
[ 160885-98-3 ]
N-(4-methoxybenzenesulfonyl)-L-norvalinyl-L-valinol [ No CAS ]

References: [1]Journal of Organic Chemistry,2000,vol. 65,p. 5048 - 5056.

14
[ 120-35-4 ]
[ 98-68-0 ]
3-(4-Methoxy-benzenesulfonylamino)-4-methoxy-N-phenyl-benzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With pyridine; In ethyl acetate;	Example 121 3-(4-Methoxy-benzenesulfonylamino)-4-methoxy-N-phenyl-benzamide A mixture of 4-methoxybenzenesulfonyl chloride (2.21 g, 10.0 mmol), 3-amino-4-methoxy-N-phenyl-benzamide (2.43 g, 10.0 mmol) and pyridine (25 mL) was allowed to stand at room temperature until thin layer chromatography indicated the reaction to be complete. The mixture was then partitioned between water (400 mL) and ethyl acetate (400 mL). The layers were separated and the organic layer washed with water (2*400 mL), 1N HCL (100 mL), and brine (100 mL) dried (magnesium sulfate), filtered and stripped of solvent. Trituration of the residue in hexanes/ethyl acetate (1:1) and filtration afforded the product (3.754 g); m.p. 184-186 C. Calculated for C21H20N2O5S: C, 61.15; H, 4.89; N, 6.79. Found: C, 61.20; H, 5.03; N, 6.78.

References: [1]Patent: US6268387,2001,B1 .

15
[ 91640-73-2 ]
[ 98-68-0 ]
[ 1073697-20-7 ]

Yield	Reaction Conditions	Operation in experiment
96%	With triethylamine; In dichloromethane; at 0 - 20℃;	2-(2-(4-Methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acetic acid S15; Methyl 2-(2-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate; <strong>[91640-73-2]2-(1,2,3,4-Tetrahydroisoquinolin-1-yl)acetic acid methyl ester</strong> (9.55 g, 46.5 mmol) was dissolved in DCM (150 ml), and triethylamine (14.9 ml, 106 mmol) was added thereto. The reaction mixture was cooled to 0 C., and a solution of methoxybenzenesulfonyl chloride (8.74 g, 42.3 mmol) in DCM (100 ml) was added dropwise thereto. The reaction mixture was stirred overnight at room temperature. For working up, 100 ml of a 0.5 M HCl solution were added and then the phases were separated. The organic phase was first washed with water and then dried over sodium sulfate. The crude product was purified by column chromatography on silica gel (mobile phase: DCM).Yield: 15.22 g (96%)
96%	With triethylamine; In dichloromethane; at 0 - 20℃;	Et3N (14.9 ml, 106 mmol) was added to a solution of the ester (9.55 g, 46.5 mmol) in CH2Cl2 (150 ml). The reaction mixture was cooled to 0 C. and a solution of the sulfonyl halide (42 mmol) in CH2Cl2 (100 ml) was added dropwise. After stirring at RT overnight, 0.5 M HCl (100 ml) was added and the organic phase was separated off and washed with water. After drying over Na2SO4 and filtration, the solvent was removed in vacuo. The product was purified via column chromatography (silica, CH2Cl2). Yield: 15.22 g 96%.

References: [1]Patent: US2008/312231,2008,A1 .Location in patent: Page/Page column 42.
[2]Patent: US2009/253669,2009,A1 .Location in patent: Page/Page column 43.

16
[ 1185265-52-4 ]
[ 98-68-0 ]
[ 350800-81-6 ]
[ 1185265-19-3 ]

Yield	Reaction Conditions	Operation in experiment
	In pyridine;	N-{6-[7-(2,2-Dimethyl-propionyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-1H-indol-4-yl}-4-methoxy-benzenesulfonamide. Substituting N-(6-bromo-1H-indol-4-yl)-4-methoxy-benzenesulfonamide (prepared by treatment of <strong>[350800-81-6]6-bromo-1H-indol-4-ylamine</strong> with 4-methoxy-benzenesulfonyl chloride in pyridine) for 6-bromo-2,2-dimethyl-4H-benzo[1,4]oxazin-3-one. MP=231-233 C, (M+H)+=504.

References: [1]Patent: US2009/215724,2009,A1 .

17
[ 98-68-0 ]
[ 350800-81-6 ]
[ 1185265-52-4 ]

Yield	Reaction Conditions	Operation in experiment
	With pyridine;	N-{6-[7-(2,2-Dimethyl-propionyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-1H-indol-4-yl}-4-methoxy-benzenesulfonamide. Substituting N-(6-bromo-1H-indol-4-yl)-4-methoxy-benzenesulfonamide (prepared by treatment of <strong>[350800-81-6]6-bromo-1H-indol-4-ylamine</strong> with 4-methoxy-benzenesulfonyl chloride in pyridine) for 6-bromo-2,2-dimethyl-4H-benzo[1,4]oxazin-3-one. MP=231-233 C, (M+H)+=504.

References: [1]Patent: US2009/215724,2009,A1 .Location in patent: Page/Page column 27.

18
[ 98-68-0 ]
[ 120068-37-3 ]
[ 1225373-73-8 ]

References: [1]Journal of Chemical Research,2010,p. 92 - 94.

19
[ 165669-35-2 ]
[ 98-68-0 ]
[ 1265023-89-9 ]

Yield	Reaction Conditions	Operation in experiment
97%	With tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide; In dichloromethane;	7-Bromo-l-(4-methoxy-benzenesulfonyl)-lH-pyrrolo[2,3-c]pyridine (3 in Scheme 1):; Potassium hydroxide (1.71 g, 30.45 mmol) and tetra-n-butylammonium hydrogen sulfate (0.345 g, 1.015 mmol) were added to a solution of 2 (2.0 g, 10.15 mmol) in dichloromethane (100 mL).The reaction mixture thus formed was stirred for 30 min. 4-Methoxysulfonyl chloride (4.2 g,20.3 mmol) was added slowly to the reaction mixture. After 1 h the mixture was quenched with water and extracted with CΗ2CI2 The combined organic layers were dried over MgSO4, the dried solution was filtered, and the filtrate was concentrated. The residue was purified by silica gel column chromatography (EtOAc: w-hexane = 1: 1) to afford 3 (3.6 g, 97%).1H NMR (500 MHz, CDCl3): δ 3.84 (s, 3H), 6.72 (d, IH, J=3.7 Hz), 6.94 (d, 2H, J= 8.9Hz), 7.46 (d, IH, J =5.1 Hz), 7.77 (d, 2H, J= 8.9 Hz), 8.07 (d, IH, J=3.7 Hz), 8.12 (d, IH, J =5.2 Hz).

References: [1]Patent: WO2011/19634,2011,A2 .Location in patent: Page/Page column 13.
[2]Journal of Medicinal Chemistry,2013,vol. 56,p. 8008 - 8018.

20
[ 4771-49-7 ]
[ 98-68-0 ]
[ 1356240-02-2 ]

References: [1]Journal of Agricultural and Food Chemistry,2013,vol. 61,p. 5696 - 5705.

21
[ 1455-20-5 ]
[ 98-68-0 ]
2-n-butyl-4-(4-methoxyphenyl)thiophene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
98.3%	With bis(benzonitrile)palladium(II) dichloride; tributylphosphine; 25,26,27,28-tetrakis(hydroxy)calix[4]arene; sodium carbonate; In 1,4-dioxane; at 100℃; for 20h;Inert atmosphere;	The synthesis reactor was charged with lmmo 1 compound of formula (I) and 2 mmo 1 compound of formula (II), followed by the addition of 4 ml of solvent 1, 4-dioxane and 5 mmol of sodium carbonate were added, and 0.07 mmol of Pd (PhCN)2Cl2 and 80 mg of a cup having a mass ratio of 1: 0.8 were added with stirring [4] a mixture of aromatic hydrocarbons and tributylphosphine, followed by argon-vacuum evacuation for three times, followed by sealing and stirring Gradually warm to l00 C reaction 20h, after the completion of the reaction to cool to room temperature, the mixture was filtered, steamed, after silica gel column chromatography To give a compound of formula (III) in a yield of 98.3% and a purity of 98.9% (HPLC).

References: [1]Patent: CN103980247,2016,B .Location in patent: Paragraph 0036-0038.
[2]Chemical Science,2013,vol. 5,p. 392 - 396.

22
[ 3095-48-5 ]
[ 98-68-0 ]
[ 1616605-04-9 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,p. 3100 - 3103.
[2]Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,p. 3100 - 3103.

23
[ 92914-74-4 ]
[ 98-68-0 ]
N-isoxazolo[5,4-b]pyridin-3-yl-4-methoxybenzenesulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
76%	With pyridine; In tetrahydrofuran; at 60 - 65℃; for 0.25h;Microwave irradiation;	General procedure: To a solution of <strong>[92914-74-4]3-aminoisoxazolo[5,4-b]pyridine</strong>(1) (1.35 g, 0.01 mol) in 100 mL of tetrahydrofurane tetrahydrofurane,a few drops of anhydrous pyridine and 0.01mol of the appropriate arylsulfonyl chlorides: benzene-,4-bromobenzene-, 4-chlorobenzene-, ptoluene-and 4-methoxybenzenesulfonyl chlorideswere added. The reaction mixture was heated underreflux while being stirred in the microwave reactorin an aluminum bath at 60-65OC for 15 min (3 5min with 5 min breaks) at microwave power P = 240W. The solvent was evaporated under vacuum andthe residue obtained was triturated with water, filtered,dried and crystallized from ethanol.

References: [1]Acta poloniae pharmaceutica,2015,vol. 72,p. 727 - 735.

24
[ 4265-25-2 ]
[ 98-68-0 ]
3-((4-methoxyphenyl)thio)-2-methylbenzofuran [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
70%	With triphenylphosphine; potassium iodide; In ethanol; at 100℃; for 24h;Sealed tube;	General procedure: 2-substituted benzofurans (0.5 mmol), aryl sulfonyl chloride (0.6 mmol), PPh3 (262 mg, 1.0 mmol), KI (17 mg, 0.1 mmol) or KI (42 mg, 0.25 mmol) and EtOH (1.0 mL) were mixed in a sealed tube. The mixture was stirred at 90 C or 100 C for 12 hours or 24 hours. Then, the solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography to afford the pure product.

References: [1]Tetrahedron Letters,2016,vol. 57,p. 5330 - 5333.

25
[ 6174-86-3 ]
[ 98-68-0 ]
3-Chloro-4-methyl-2-oxo-2H-chromen-7-yl 4-methoxybenzenesulfonate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
88%	With triethylamine; In tetrahydrofuran; at 20℃; for 4h;	General procedure: Coumarin sulfonates 1-38 were synthesized by reactingdifferent hydroxylated coumarin derivatives (1 mmol) withcommercially available sulfonyl chlorides derivatives (1.2 mmol) inTHF (15 mL) and triethyl amine (1 mmol) was used as base. Reactionmixture was stirred for 4 h at room temperature to afford avariety of coumarin sulfonate esters 1e38. TLC monitoring wasused to determine the progress of the reaction. After the completionof reaction, THF was evaporated under reduced pressure andthe solid product obtained was washed with distilled water anddried under vacuum. The products were recrystallized in methanoland gave good yields. All the synthetic compounds 1-38 werecharacterized by different spectroscopic techniques such as EI-MS,HREI-MS, 1H-NMR, and 13C-NMR.

References: [1]European Journal of Medicinal Chemistry,2017,vol. 131,p. 29 - 47.

26
[ 98-68-0 ]
[ 56293-29-9 ]
12-N-(4-methoxybenzenesulfonyl)aloperine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
80%	With potassium carbonate; In dichloromethane; at 0 - 20℃;	General procedure: At 0 ° C,Take buprofezin(1) 0.5 g (0.002 mol)Was added to 20 ml of dichloromethane, And then to the reaction solution 1.8 g (0.006 mol) of anhydrous potassium carbonate and the substituted benzenesulfonyl chloride or benzoyl chloride (0.0018 mol) were successively added, and the mixture was stirred at room temperature mix. TLC was detected until the reaction was complete. Organic phase concentrated evaporated, add methylene chloride solvent dissolved, followed by water, saturated salt water washing. Drying the dichloromethane layer and evaporating the solvent with a rotary evaporator to obtain a crude product of a 12-N acyl or sulfonylsuccinate derivative, Add 20ml methylene chloride solvent dissolved, mixed with silica gel, and then by column chromatography separation, to be 12-N-acyl or sulfonyl-podic acid pure 3Or 4.

References: [1]Patent: CN106892920,2017,A .Location in patent: Paragraph 0117; 0118; 0119; 0153; 0154; 0155.

27
[ 1080-12-2 ]
[ 98-68-0 ]
(E)-2-methoxy-4-(3-oxobut-1-enyl)phenyl 4-methoxybenzenesulfonate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82.2%	With triethylamine; In methanol; at 20℃;	General procedure: Solutions of selected methyl ketones (2 mmol) in methanol(6 mL) were stirred and corresponding sulfonylchlorides (2.4 mmol) were added. Then, triethylamine(0.6 mL) was added dropwise. The mixtures were stirredovernight at room temperature. After completion of thereactions, mixtures were poured into iced water withstirring. In some cases (for our compounds 7f, 7g, 8e, 8f,8g, and 9g; see below), the formed precipitate was filteredand washed with cold diethyl ether. In other cases, whenno precipitate formed, the organic layer was extractedwith dichloromethane (3 × 50 mL), dried over anhydrousNa2SO4 and evaporated under vacuum. The residue waspurified by short column chromatography on silica gel,using dichloromethane as eluent. The oil obtained usuallycrystallized; if not, the oily residue was dissolved indiethyl ether from which products crystallized on standingin a deepfreeze. Crude products were washed with coldether, and 21 pure, mostly white crystals were obtained, asfollows:

References: [1]Medicinal Chemistry Research,2019,vol. 28,p. 279 - 291.

28
[ 98-68-0 ]
[ 5294-61-1 ]
N-(2,6-dimethylphenyl)-2-(4-((4-methoxyphenyl)sulfonyl)piperazin-1-yl)acetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
91%	With triethylamine; In dichloromethane; at 25℃; for 8.0h;	General procedure: An equimolar mixture of N-(2,6-dimethy lphenyl)-2-(piperazin-1-yl)acetamide 4 (0.001 mol) and different substituted benzene sulfonyl chlorides 5a-e (0.001 mol) in methylene dichloride were stirred for about 8 h in presence of triethylamine at 25oC. The completion of the reaction was checked by TLC. Then it was poured into ice-cold water and extracted with MDC. The organic layer was washed with brine solution, dried over anhydrous sodium sulphate and concentrated under reduced pressure to get piperazine sulphonamide derivatives 6a-e in high yield.

References: [1]Oriental Journal of Chemistry,2019,vol. 35,p. 157 - 166.

29
[ 38226-86-7 ]
[ 98-68-0 ]
5-hydroxy-2-(4-methoxyphenyl)-8,8-dimethyl-4-oxo-4,8,9,10-tetrahydropyrano[2,3-f]chromen-3-yl 4-methoxybenzenesulfonate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82.8%	With triethylamine; In dichloromethane; at 25℃; for 4h;	General procedure: To a mechanically stirred suspension of suspension of 1 (0.21 g, 0.53 mmol) in 30 ml CH2Cl2 were added triethylamine (0.5 ml) and aromatic sulfonyl chloride (0.53 mmol) at 25 C for 4 h. The reaction process was detected by TLC method. Then, antagonized by dilute sodium hydroxide, extracted, and washed with ether and water, evaporated under vacuum. Finally, the mixture was recrys-tallizated from ethyl acetate , providing a total product yield of 65.4%-88.6 %.

References: [1]Pharmazie,2019,vol. 74,p. 73 - 78.

30
[ 101601-80-3 ]
[ 98-68-0 ]
4-methoxy-N-(2-phenylpyridin-3-yl)benzenesulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
83%	With pyridine; dmap; In dichloromethane; at 20 - 60℃; for 6h;	General procedure: 2-bromopyridin-3-amine (1) (500 mg, 2.89 mmol) and (2-methoxyphenyl)boronic acid (483 mg, 3.18 mmol) was dissolvedin toluene/H2O (2/1, v/v, 15 mL). Then, K2CO3 (1.6 g, 11.56 mmol)and Pd(PPh3)4 (167 mg, 0.145 mmol) were added, the reactionmixture was stirred at 80 C for 8 h with N2 atmosphere. The solventwas removed under reduced pressure, then the mixture wasextracted with EA/H2O (3/1, v/v, 50 mL) for three times and the EAlayer was merged. The organic layer was dried with Na2SO4 andconcentrated under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography(PE: EA 2: 1) to give a yellowish solid 2-(2-methoxyphenyl)pyridin-3-amine (2a) (310 mg, 60%).Compound 2a (100 mg, 0.499 mmol) and DMAP (61 mg,0.499 mmol) was dissolved in CH2Cl2 (8 mL), and pyridine (1 mL)was added subsequently. 4-methoxybenzenesulfonyl chloride(103 mg, 0.499 mmol) was added dropwise into the mixture atroom temperature. Then, the mixture turned to 60 C and stirredunder reflux for 6 h. CH2Cl2 was removed and the mixture wasextracted with EA/H2O (3/1, v/v, 30 mL) for three times. The organiclayer was collected and dried with Na2SO4, then concentrated underreduced pressure to obtain the crude product. The crudeproduct was purified by silica gel column chromatography (PE:EA 3: 1) to give a white solid HoAn1 (122 mg, 66%).

References: [1]European Journal of Medicinal Chemistry,2021,vol. 211.

Historical Records

Technical Information

• Alkyl Halide Occurrence • Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Friedel-Crafts Reaction • General Reactivity • Grignard Reaction • Hiyama Cross-Coupling Reaction • Hydrogenolysis of Benzyl Ether • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Nomenclature of Ethers • Preparation of Alkylbenzene • Preparation of Ethers • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Ethers • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Vilsmeier-Haack Reaction

Related Functional Groups of
[ 98-68-0 ]

Aryls

A556789 [23095-31-0]

3,4-Dimethoxybenzenesulfonyl chloride

Similarity: 0.94

A755689 [63624-28-2]

2,4-Dimethoxybenzene-1-sulfonyl chloride

Similarity: 0.91

A602500 [10130-87-7]

2-Methoxybenzenesulfonyl chloride

Similarity: 0.91

A852681 [2688-85-9]

2-Phenoxybenzene sulfonyl chloride

Similarity: 0.88

A150365 [39614-62-5]

3,4,5-Trimethoxybenzene-1-sulfonyl chloride

Similarity: 0.88

Chlorides

A556789 [23095-31-0]

3,4-Dimethoxybenzenesulfonyl chloride

Similarity: 0.94

A755689 [63624-28-2]

2,4-Dimethoxybenzene-1-sulfonyl chloride

Similarity: 0.91

A602500 [10130-87-7]

2-Methoxybenzenesulfonyl chloride

Similarity: 0.91

A852681 [2688-85-9]

2-Phenoxybenzene sulfonyl chloride

Similarity: 0.88

A150365 [39614-62-5]

3,4,5-Trimethoxybenzene-1-sulfonyl chloride

Similarity: 0.88

Ethers

A556789 [23095-31-0]

3,4-Dimethoxybenzenesulfonyl chloride

Similarity: 0.94

A755689 [63624-28-2]

2,4-Dimethoxybenzene-1-sulfonyl chloride

Similarity: 0.91

A602500 [10130-87-7]

2-Methoxybenzenesulfonyl chloride

Similarity: 0.91

A852681 [2688-85-9]

2-Phenoxybenzene sulfonyl chloride

Similarity: 0.88

A150365 [39614-62-5]

3,4,5-Trimethoxybenzene-1-sulfonyl chloride

Similarity: 0.88

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

{[proInfo.proName]}

CAS No.: 98-68-0

{[proInfo.proName]}

CAS No.: 98-68-0

Alternative Products

Product Details of [ 98-68-0 ]

Safety of [ 98-68-0 ]

Computational Chemistry of [ 98-68-0 ] Show Less

Physicochemical Properties

Lipophilicity

Water Solubility

Pharmacokinetics

Druglikeness

Medicinal Chemistry

Application In Synthesis of [ 98-68-0 ]

[ 98-68-0 ] Synthesis Path-Upstream 1~1

[ 98-68-0 ] Synthesis Path-Downstream 1~30

Related Products

Historical Records

Technical Information

Categories

Related Functional Groups of
[ 98-68-0 ]

Aryls

Chlorides

Ethers

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Molarity Calculator

Total Compounds Calculator

Dissolution Calculator

{[proInfo.proName]}

CAS No.: 98-68-0

{[proInfo.proName]}

CAS No.: 98-68-0

Alternative Products

Product Details of [ 98-68-0 ]

Safety of [ 98-68-0 ]

Computational Chemistry of [ 98-68-0 ] Show Less

Physicochemical Properties

Lipophilicity

Water Solubility

Pharmacokinetics

Druglikeness

Medicinal Chemistry

Application In Synthesis of [ 98-68-0 ]

[ 98-68-0 ] Synthesis Path-Upstream 1~1

[ 98-68-0 ] Synthesis Path-Downstream 1~30

Related Products

Historical Records

Technical Information

Categories

Related Functional Groups of [ 98-68-0 ]

Aryls

Chlorides

Ethers

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Molarity Calculator

Total Compounds Calculator

Dissolution Calculator

Related Functional Groups of
[ 98-68-0 ]