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Chemical Structure| 960492-85-7 Chemical Structure| 960492-85-7

Structure of 960492-85-7

Chemical Structure| 960492-85-7

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Product Details of [ 960492-85-7 ]

CAS No. :960492-85-7
Formula : C11H13ClF3N
M.W : 251.68
SMILES Code : FC(C1=CC=CC=C1CC2CNC2)(F)F.[H]Cl
MDL No. :MFCD12406975

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Application In Synthesis of [ 960492-85-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 960492-85-7 ]

[ 960492-85-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 960492-85-7 ]
  • [ 65202-50-8 ]
  • methyl 6-{3-[2-(trifluoromethyl)benzyl]azetidin-1-yl}pyridazine-3-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In 1,4-dioxane; for 48h;Heating / reflux; Step 5: Methyl 6-{3-[2-(trifluoromethyl)benzyllazetidin-l-vUpyridazine-3-carboxylate; To a solution of 3-[2-(trifluoromethyl)benzyl]azetidine hydrochloride (327 mg, 1.3 mmol) and methyl beta-chloropyridazine-S-carboxylate (329 mg, 1.3 mmol) in 5 mL of dioxane was added potassium carbonate (539 mg, 3.9 mmol). It was heated to reflux for 2 days. The reaction mixture was allowed to cool to room temperature and poured into a separatory funnel containing KH2PO4 buffer. The aqueous layer was extracted with 3 portions of ethyl acetate. The combined organic layers were washed with brine, dried over MgSO4, filtered and concentrated to give the desired product.
 

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