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Chemical Structure| 959992-61-1 Chemical Structure| 959992-61-1

Structure of 959992-61-1

Chemical Structure| 959992-61-1

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Product Details of [ 959992-61-1 ]

CAS No. :959992-61-1
Formula : C7H6Br2N2O3
M.W : 325.94
SMILES Code : O=[N+](C1=NC(Br)=CC=C1OCCBr)[O-]
MDL No. :MFCD26397782

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Application In Synthesis of [ 959992-61-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 959992-61-1 ]

[ 959992-61-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 959992-61-1 ]
  • [ 959992-62-2 ]
YieldReaction ConditionsOperation in experiment
55% To a solution of 6-bromo-3-(2-bromoethoxy)-2-nitropyridine (4.5 g, 13.8 mmol) in glacial acetic acid (23 ml) was added iron (powder, 3.08 g, 55.2 mmol) in one portion. The reaction mixture was heated to 90C during 5 hours, then cooled down, diluted in ethyl acetate and filtered through a silica gel plug using ethyl acetate as eluent. After evaporation, the residue was dissolved in DMF (50 ml). Potassium carbonate (5.72 g, 41.4 mmol) was added and the mixture was heated to 90C for 2 hours, then to 70C overnight. After evaporation of solvent, the residue was dissolved in DCM, salts were removed by filtration, and the crude compound was purified by silica gel flash chromatography (30 to 50% ethyl acetate in petroleum ether) to give 6-bromo-3,4-dihydro-2H-pyrido[3,2- b][l,4]oxazine as a pale yellow oil (1.64 g, 55%); Mass Spectrum [M+H]+ = 215; 1H NMR Spectrum (CDC13) 3.54-3.60 (m, 2H), 4.19 (t, 2H), 5.35 (bs, IH), 6.66 (d, IH), 6.82 (d, IH).
 

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