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Chemical Structure| 959163-01-0 Chemical Structure| 959163-01-0

Structure of 959163-01-0

Chemical Structure| 959163-01-0

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Product Details of [ 959163-01-0 ]

CAS No. :959163-01-0
Formula : C8H9ClN2O
M.W : 184.62
SMILES Code : O=CC1=CN=C(C=C1NCC)Cl
MDL No. :MFCD18452001

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Application In Synthesis of [ 959163-01-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 959163-01-0 ]

[ 959163-01-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 959163-01-0 ]
  • [ 500912-18-5 ]
  • [ 1588424-20-7 ]
YieldReaction ConditionsOperation in experiment
61% With potassium carbonate; In N,N-dimethyl-formamide; at 100℃; for 16h;Inert atmosphere; A mixture of 6-chloro-4-(ethyl amino) nicotinaldehyde (Scheme 1 compound 6) (1.7 g, 9.32 mmol), Scheme 56 compound 4 (2.0 g, 12.11 mmol) and K2C03 (3.8 g, 27.96 mmol) in dry DMF (10 mL) was heated to 100 C under nitrogen atmosphere for 16 h. After TLC showed the starting material was completely consumed, the reaction mixture was cooled to RT, diluted with EtOAc (2 x 50 mL), washed with water (2 x 20 mL) and brine (10 mL) then dried over Na2S04 and concentrated to give a residue which was purified by flash chromatography on silica gel (eluting with petroleum ether/EtOAc 100/0 gradually increasing to 60/40) to give 7-chloro-l-ethyl-3-(2-fluoro-6-methoxyphenyl)-l,6-naphthyridin-2(lH)- imine (800 mg, 26%) as a yellow solid. 1H NMR (400 MHz, DMSO-d6): delta 8.41 (s, 1H), 7.51 (q, J= 8.0 Hz, 1H), 7.41 (d, J= 10.6 Hz, 2H), 7.07-6.92 (m, 2H), 4.26 (m, 2H), 3.77 (d, J = 2.4 Hz, 3H), 1.22-1.16 (m, 3H). MS [ESI, MH+] = 332.09.
 

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