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Chemical Structure| 958646-69-0 Chemical Structure| 958646-69-0

Structure of 958646-69-0

Chemical Structure| 958646-69-0

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Product Details of [ 958646-69-0 ]

CAS No. :958646-69-0
Formula : C6H7BClNO2
M.W : 171.39
SMILES Code : ClC1=CC=C(N)C=C1B(O)O

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 958646-69-0 ]

[ 958646-69-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 958646-69-0 ]
  • [ 235426-31-0 ]
  • [ 1128191-82-1 ]
YieldReaction ConditionsOperation in experiment
50% With potassium acetate;tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; water; at 100.0℃; for 1.41667h;Microwave irradiation; Example 12N-[4-chloro-3-(l,5-dimethylimidazol-2-yl)phenyl]-2-methoxy-pyridine-3-carboxamide12A. 4-Chloro-3-(l,5-dimethylimidazol-2-yl)aniline; In a 35 mL vial was placed 5-amino-2-chlorophenylboronic acid (0.7 g, 4.08 mmol), 2- bromo-l,5-dimethyl-lH-imidazole (1.072 g, 6.13 mmol), and KOAc (1.203 g, 12.25 mmol) in dioxane (8 mL) to give a yellow suspension. The reaction mixture was diluted with water (2.0 mL) and after bubbling in nitrogen for 10 min, Pd(PPlIs)4 (0.472 g, 0.41 mmol) was added. The reaction was heated using a microwave at 100 0C for 85 min. After concentration in vacuo, the residue was purified by ISCO MPLC (10% MeOH in DCM) to give the product (0.45 g, 50% yield). 1H NMR (DMSO-d6) delta 2.19 (s, 3 H), 3.30 (s, 3 H), 5.41 (s, 2 H), 6.56 (d, 1 H), 6.66 (m, 2 H), 7.16 (d, 1 H). MS (M+H+) = 222.
 

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