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Chemical Structure| 956137-23-8 Chemical Structure| 956137-23-8

Structure of 956137-23-8

Chemical Structure| 956137-23-8

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Product Details of [ 956137-23-8 ]

CAS No. :956137-23-8
Formula : C20H24N2O2
M.W : 324.42
SMILES Code : O=C(OC)C[C@H]1CC[C@H](C2=CC=C(C3=NC=C(N)C=C3)C=C2)CC1

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Application In Synthesis of [ 956137-23-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 956137-23-8 ]

[ 956137-23-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 956137-23-8 ]
  • [ 134872-23-4 ]
  • (4-{4-[5-(5-methylsulfanyl-pyridin-2-ylamino)-pyridin-2-yl]-phenyl}-cyclohexyl)-acetic acid methyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
With caesium carbonate;tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 80℃; for 18h;Sealed vessel; 2-Bromo-5-methylsulfanyl-pyridiϖe (51 mg, 0.25 mmol) and {4-[4-(5-Amino-pyridin-2-yl)- phenyl]-cyclohexyl}-acetic acid methyl ester (75 mg, 0.25 mmol) were dissolved in 1 ,4- dioxane (2 mL) in a pressure vessel. Pd2dba3 (7 mg, 0.008 mmol) and XANTPHOS (6 mg, 0.01 mmol) were added, followed by cesium carbonate (163 mg, 0.50 mmol). The mixture was sparged with nitrogen for 10 minutes, then the vessel was sealed and heated at 800C for 18 hours. The mixture was partitioned between EtOAc and water, then the organic layer was washed with brine, dried with magnesium sulfate, filtered, and concentrated via rotary evaporation. The crude material was used in the next step without further purification; MS (M+H)+ 448.3.
 

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