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Chemical Structure| 95360-33-1 Chemical Structure| 95360-33-1
Chemical Structure| 95360-33-1

*Storage: Inert atmosphere,2-8°C.

Methyl 2-(2-(chloromethyl)phenyl)acetate

CAS No.: 95360-33-1

4.5 *For Research Use Only !

Cat. No.: A566121 Purity: 98%

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Product Details of [ 95360-33-1 ]

CAS No. :95360-33-1
Formula : C10H11ClO2
M.W : 198.65
SMILES Code : O=C(OC)CC1=CC=CC=C1CCl
MDL No. :MFCD09832998

Safety of [ 95360-33-1 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H314
Precautionary Statements:P264-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P403+P233-P501
Class:8
UN#:3265
Packing Group:

Application In Synthesis [ 95360-33-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 95360-33-1 ]

[ 95360-33-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 95360-33-1 ]
  • [ 34486-06-1 ]
  • [ 187327-30-6 ]
YieldReaction ConditionsOperation in experiment
83% With sodium hydroxide; sodium iodide; In hexane; N,N-dimethyl-formamide; toluene; EXAMPLE 2 This Example illustrates the preparation of methyl 2-(6-trifluoromethylpyrid-2-yloxymethyl)phenylacetate (Compound No.3 in Table 1) and its conversion to the corresponding 3-methoxyacrylate (Compound No.177 in Table I of EP-A-0278595). A mixture of <strong>[34486-06-1]2-hydroxy-6-trifluoromethylpyridine</strong> (2.0 g, 12.3 mmol), sodium hydroxide (0.52 g, 12.9 mmol) and 15-crown-5 (1 drop) in dry toluene (25 ml) were stirred at reflux for 2 hours. The toluene was removed under reduced pressure and the white salt residue was dissolved in dry DMF (15 ml). Methyl 2-chloromethylphenylacetate (2.44 g, 12.3 mmol) in dry DMF (15 ml) was added dropwise along with sodium iodide (10 mg). The mixture was stirred at 75° C. for 2 hours, poured into water and extracted with diethyl ether. The ether extracts were washed with water, dried and the ether removed in vacuo leaving an oil which was purified by column chromatography (silica eluted with 10percent ethyl acetate in hexane) to give methyl 2-(6-tri-fluoromethylpyrid-2-yloxymethyl)phenylacetate (3.3 g, 83percent) (Compound No.5 in Table 1) as a yellow oil; 1 H NMR (270 MHz)delta: 3.68(3H,s), 3.84(2H,s), 5.46(2H,s), 6.89(1H,d), 7,20-7.70(6H,m) ppm.
83% A mixture of <strong>[34486-06-1]2-hydroxy-6-trifluoromethylpyridine</strong> (2.0 g, 12.3 mmol), sodium hydroxide (0.52 g, 12.9 mmol) and 15-crown-S (1 drop) in dry toluene (25 mL) was stirred under reflux for 2 hours. Toluene was removed under reduced pressure and the white salt residue was dissolved in dry dimethylformamide (DMF) (15 mL). Methyl 2-chloromethylphenylacetate (2.44 g, 12.3 mmol) in dry DMF (15 mL) was added dropwise along with sodium iodide (10 mg). The mixture was stirred at 75 °C for 2 hours, then poured into water and extracted with diethyl ether. The ether extracts were washed with water, dried and the remaining ether removed in vacuo leaving an oil, which was purified by column chromatography (silica eluted with 10percent ethyl acetate in hexane) to give methyl 2-(6-tri-fluoromethylpyrid-2-yloxymethyl)phenylacetate(3.3 g, 83percent).
 

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