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Chemical Structure| 95262-10-5 Chemical Structure| 95262-10-5

Structure of 95262-10-5

Chemical Structure| 95262-10-5

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Product Details of [ 95262-10-5 ]

CAS No. :95262-10-5
Formula : C9H8FNO3
M.W : 197.16
SMILES Code : O=C(O)CC(NC1=CC=C(F)C=C1)=O
MDL No. :MFCD00201972

Safety of [ 95262-10-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P264-P270-P301+P312-P330-P501

Application In Synthesis of [ 95262-10-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 95262-10-5 ]

[ 95262-10-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 95262-10-5 ]
  • [ 102877-78-1 ]
  • N-(4-fluorophenyl)-N-(4-(pyridin-4-yloxy)phenyl)malonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
76% With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 20℃; for 2h; A solution of <strong>[102877-78-1]4-(4-aminophenoxy)pyridine</strong> (93 mg, 0.50 mmol) in DMF was treated with 3-(4-fluorophenylamino)-3-oxopropanoic acid (99 mg, 0.50 mmol), DIPEA (113 muL, 0.65 mmol) and TBTU (209 mg, 0.65 mmol) and the mixture was stirred at RT for 2 h. The mixture was concentrated to remove the DMF and the residue partitioned between EtOAc and saturated sodium bicarbonate solution. The EtOAc phase was washed with saturated sodium bicarbonate solution, brine, dried (MgSO4) and concentrated to give the title compound as an off-white foam (140 mg, 76%). 1H NMR (DMSO-d6) delta 10.30 (s, 1H), 10.24 (s, 1H), 8.43 (dd, 2H, J=5.5, 1.5 Hz), 7.70 (d, 2H, J=9.1 Hz), 7.63-7.60 (m, 2H), 7.17-7.14 (m, 4H), 6.89 (dd, 2H, J=5.5, 1.5 Hz), 3.46 (s, 2H); MS (ESI+) m/z 365.9 (M+H)+.
 

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