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Chemical Structure| 949556-71-2 Chemical Structure| 949556-71-2

Structure of 949556-71-2

Chemical Structure| 949556-71-2

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Product Details of [ 949556-71-2 ]

CAS No. :949556-71-2
Formula : C20H16FIN4O2
M.W : 490.27
SMILES Code : NC1=CC=C(OC2=C3C(N(CC4=CC=C(OC)C=C4)N=C3I)=NC=C2)C(F)=C1

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Application In Synthesis of [ 949556-71-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 949556-71-2 ]

[ 949556-71-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 389621-84-5 ]
  • [ 949556-71-2 ]
  • [ 949558-41-2 ]
YieldReaction ConditionsOperation in experiment
12% Step C: Preparation of (4-(4-(4-amino-2-fluorophenoxy)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)phenyl)(morpholino)methanone: A mixture of 4-(1-(4-methoxybenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorobenzenamine (0.30 g, 0.612 mmol; prepared as in Example 7, Step B), Cs2CO3 (0.299 g, 0.918 mmol), and <strong>[389621-84-5]4-(morpholine-4-carbonyl)phenylboronic acid</strong> (0.151 g, 0.643 mmol) in DME (3 mL) was degassed under nitrogen for 10 minutes and tetrakistriphenylphosphinepalladium (0.035 g, 0.03 mmol) was added. The reaction mixture was heated at 85 C. for 15 hours. The precipitate was removed by filtration with a mixture of EtOAc and MeOH. The filtrate was concentrated and the crude material was purified by silica gel flash column chromatography (1% MeOH in CH2Cl2) to afford 39 mg (12%) of the desired product. LRMS (APCI pos) m/e 554.1 (M+1).
 

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