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Chemical Structure| 945724-02-7 Chemical Structure| 945724-02-7

Structure of 945724-02-7

Chemical Structure| 945724-02-7

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Product Details of [ 945724-02-7 ]

CAS No. :945724-02-7
Formula : C11H12BrNO2
M.W : 270.12
SMILES Code : O=C(C1=CC=C(Br)C=C1O)/C=C/N(C)C
MDL No. :MFCD28402337
InChI Key :RPUCSDNSVNQXSP-AATRIKPKSA-N
Pubchem ID :11737295

Safety of [ 945724-02-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 945724-02-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 945724-02-7 ]

[ 945724-02-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 4637-24-5 ]
  • [ 55736-69-1 ]
  • [ 945724-02-7 ]
YieldReaction ConditionsOperation in experiment
71% In benzene; for 4.0h;Heating / reflux; Intermediate 3;(2.pound.)-1-(4-bromo-2-hydroxyphenyl)-3-(dlmethylamlno)prop-2-en-1-one.; To a solution of i-(2-bromo-6-hydroxyphenyI)ethanone (35.8 g, 167 mmol) in dry benzene (800 mL) was added N.N-dimethylformamide dimethylacetal (44 mL, 333 mmol) and <n="23"/>the solution was heated to reflux for 4 h. The reaction mixture was then evaporated to dryness, dissolved in CHCI3 (300 rrL) and filtered through SiO2 (63-100 mum, 200 mL) to give after evaporation the title compound (31,9 g, 71percent) as a bright yellow solid. LC/MS data; 270.0 (M+Hf (Calculated for C11H12BrNO2 270.13). (calc. monoisotopic mass is 269.01, calc. monoisotopic mass (M+Hf = 270.01). 1H NMR data (DMSO-d6): 14.96 (s, 1H, OH), 7.93 (d, 1H, J=12.0 Hz, =CH), 7.87 (d, 1H, J = 9.0 Hz, Ar-H), 7.03 (d, 1H, J = 2.2 Hz, Ar-H)1 6,99 (dd, 1H, J1=S-O Hz7 J2=2.2 Hz, Ar-H), 5.94 (d, 1H, J=12.0 Hz, =CH), 3.21 (s, 3H, CH3), 3.00 (S, 3H1 CH3).
 

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• Alkyl Halide Occurrence • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Bucherer-Bergs Reaction • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Chan-Lam Coupling Reaction • Clemmensen Reduction • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Fischer Indole Synthesis • Friedel-Crafts Reaction • General Reactivity • Grignard Reaction • Henry Nitroaldol Reaction • Hiyama Cross-Coupling Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Hydrogenolysis of Benzyl Ether • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Lawesson's Reagent • Leuckart-Wallach Reaction • Mannich Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Alkylbenzene • Preparation of Amines • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Dihalides • Reformatsky Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Ketenes • Specialized Acylation Reagents-Vilsmeier Reagent • Stille Coupling • Stobbe Condensation • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Tebbe Olefination • Ugi Reaction • Vilsmeier-Haack Reaction • Wittig Reaction • Wolff-Kishner Reduction

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