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Chemical Structure| 944401-75-6 Chemical Structure| 944401-75-6

Structure of 944401-75-6

Chemical Structure| 944401-75-6

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Product Details of [ 944401-75-6 ]

CAS No. :944401-75-6
Formula : C11H16BFN2O2
M.W : 238.07
SMILES Code : NC1=NC=C(B2OC(C)(C)C(C)(C)O2)C=C1F
MDL No. :MFCD12923417
InChI Key :OAEDVIUUNHFXLJ-UHFFFAOYSA-N
Pubchem ID :59252052

Safety of [ 944401-75-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

Application In Synthesis of [ 944401-75-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 944401-75-6 ]

[ 944401-75-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 944401-75-6 ]
  • [ 1798-85-2 ]
  • 5-(3-cyclopropylphenyl)-3-fluoropyridin-2-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
21.5% With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In 1,4-dioxane; water; at 80℃; for 2h;Inert atmosphere; Monomer Synthesis V Pd(PPh3)4 (1.1 g, 1.03 mmol, 0.1 eq.) and Na2CO3 (1.6 g, 15.37mmol, 1.5 eq.) were added to a stirred solution of 1-bromo-3- cyclopropylbenzene (2.0 g, 10.25 mmol, 1 .0 eq.) and 3-fluoro-5-(4,4,5,5- tetramethyl-1 ,3,2-dioxaborolan-2-yl)pyridin-2-amine (2.6 g, 11.28 mmol, 1.1eq.) in a mixture of dioxane (3 mL) and water (1 .5 mL) previously degassed with argon for 30 mm. The reaction mixture was heated to 80 C for 2 h after which time it was allowed to cool to RT. The reaction mixture was then filtered through a bed of celite and the filtrate was concentrated under reduced pressure. The residue was dissolved in ethyl acetate (100 mL) thenwashed with water and brine (100 mL each). The organic layer was dried over Na2504 and concentrated under reduced pressure to afford crude product. This material was purified by flash chromatography (over silica gel 100-200 mesh) eluting with 100 % EtOAc to afford pure 5-(3- cyclopropylphenyl)-3-fluoropyridin-2-amine (500 mg; 21 .5 %)
 

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