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Chemical Structure| 943606-84-6 Chemical Structure| 943606-84-6

Structure of 943606-84-6

Chemical Structure| 943606-84-6

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Product Details of [ 943606-84-6 ]

CAS No. :943606-84-6
Formula : C10H7ClN2O2
M.W : 222.63
SMILES Code : O=[N+](C1=C(C)C=CC2=C1C=CN=C2Cl)[O-]
MDL No. :MFCD09264575
InChI Key :IWLPTUUERGDBAR-UHFFFAOYSA-N
Pubchem ID :22622221

Safety of [ 943606-84-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H320-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 943606-84-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 943606-84-6 ]

[ 943606-84-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 943606-84-6 ]
  • [ 475250-52-3 ]
  • 1-(4-methoxybenzyl)-6-methyl-5-nitroisoquinoline [ No CAS ]
YieldReaction ConditionsOperation in experiment
110 mg With tripotassium phosphate tribasic; palladium diacetate; tricyclohexylphosphine; In lithium hydroxide monohydrate; toluene; at 120℃; for 12h;Inert atmosphere; Compound 1h (100 mg, 449.18 μmol), 5a (668.72 mg, 2.70 mmol), palladium acetate (20.17 mg, 89.84 μmol),Potassium phosphate (333.72 mg, 1.57 mmol) and tricyclohexylphosphine (25.19 mg, 89.84 μmol) were added to toluene (5.0 mL) and water (1.0 mL), replaced with nitrogen three times, and stirred at 120 C. for 12 hours.After the reaction was completed, it was diluted with EA, washed with saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated. The crude product was separated and purified by silica gel column chromatography (DCM/MeOH=98/2) to obtain compound 5b (110.0 mg).
 

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