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Chemical Structure| 943541-40-0 Chemical Structure| 943541-40-0

Structure of 943541-40-0

Chemical Structure| 943541-40-0

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Product Details of [ 943541-40-0 ]

CAS No. :943541-40-0
Formula : C13H11F2NO2
M.W : 251.23
SMILES Code : O=C(OCC)C(F)(F)C1=CC=C2N=CC=CC2=C1
MDL No. :MFCD09908063

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Application In Synthesis of [ 943541-40-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 943541-40-0 ]

[ 943541-40-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 13327-31-6 ]
  • [ 383-62-0 ]
  • [ 943541-40-0 ]
YieldReaction ConditionsOperation in experiment
2.6 g With copper; In dimethyl sulfoxide; at 70℃;Inert atmosphere; 6-iodoquinoline (10.2 g, 40.0 mmol) and copper powder (6.4 g, 100.0 mmol) were added to 40 mL of DMSO, Nitrogen, and <strong>[383-62-0]ethyl 2-chloro-2,2-difluoroacetate</strong> (6.2 mL, 48.0 mmol) was added. Heated to 70 C and reacted overnight. LC-MS detection, the reaction is complete. After cooling, The filtrate was charged with saturated K2CO3 solution and EtOAc, filtered, partitioned, The aqueous phase was extracted with EtOAc. The organic phase was concentrated and chromatographed to give a yellow oil (2.6 g).
 

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