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Chemical Structure| 383-62-0 Chemical Structure| 383-62-0

Structure of 383-62-0

Chemical Structure| 383-62-0

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Product Details of [ 383-62-0 ]

CAS No. :383-62-0
Formula : C4H5ClF2O2
M.W : 158.53
SMILES Code : O=C(OCC)C(F)(Cl)F
MDL No. :MFCD00013662
InChI Key :GVCAWQUJCHZRCB-UHFFFAOYSA-N
Pubchem ID :67843

Safety of [ 383-62-0 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225-H314
Precautionary Statements:P210-P280-P305+P351+P338-P310
Class:3(8)
UN#:2924
Packing Group:

Application In Synthesis of [ 383-62-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 383-62-0 ]

[ 383-62-0 ] Synthesis Path-Downstream   1~35

  • 4
  • [ 383-62-0 ]
  • [ 3757-76-4 ]
  • [ 328-03-0 ]
  • 5
  • [ 383-62-0 ]
  • phenylmagnesium bromide [ No CAS ]
  • [ 6312-18-1 ]
  • 6
  • [ 64-17-5 ]
  • [ 76-04-0 ]
  • [ 383-62-0 ]
YieldReaction ConditionsOperation in experiment
78.5% With toluene-4-sulfonic acid; In dichloromethane; at 20 - 33℃; for 38.5h;Heating / reflux; (VO 504. 3 G (3. 87MOL) CHLORDIFLUORESSIGSaURE UND 5. 0 G p-Toluolsulfonsaure werden in 775 ml Methylenchlorid gelost und bei Raumtemperatur innerhalb von 30min mit 311. 6 G (6. 76 MOL) Ethanol versetzt (Temperaturanstieg auf 33oC). Man ruhrt 38 h unter Ruckfluss am Wasserabscheider nach und kuhlt auf Raumtemperatur ab. Zur Aufarbeitung wascht man mit Wasser (200 ml), gesattigter Natriumhydrogencarbonatlosung (200 ml) und erneut mit Wasser (200 ml), trocknet uber Natriumsulfat, filtriert und destilliert das Losungsmittel ab. Anschliesend wird durch fraktionierte Destillation WEITER AUFGEREINIGT ;-- Man erhalt 488.9 g (98% ig, 78.5 % der Theorie) an Chlordifluoressigsaureethylester (Siedepunkt 94- 96oC).
  • 7
  • [ 64-17-5 ]
  • [ 648-48-6 ]
  • [ 383-62-0 ]
  • 8
  • [ 64-17-5 ]
  • [ 1717-64-2 ]
  • [ 383-62-0 ]
  • 10
  • [ 75-89-8 ]
  • [ 383-62-0 ]
  • [ 152538-73-3 ]
  • 11
  • [ 383-62-0 ]
  • [ 1445-75-6 ]
  • diisopropyl 3,3,3-trifluoroprop-1-ynylphosphonate [ No CAS ]
  • 12
  • [ 383-62-0 ]
  • [ 1445-75-6 ]
  • ((Z)-3-Chloro-3,3-difluoro-2-hydroxy-propenyl)-phosphonic acid diisopropyl ester [ No CAS ]
  • (3-Chloro-3,3-difluoro-2-oxo-propyl)-phosphonic acid diisopropyl ester [ No CAS ]
  • 13
  • [ 383-62-0 ]
  • [ 104-54-1 ]
  • [ 17531-34-9 ]
  • 14
  • [ 383-62-0 ]
  • [ 2356-16-3 ]
  • [ 126275-27-2 ]
  • [ 126275-28-3 ]
  • 15
  • [ 383-62-0 ]
  • [ 873-75-6 ]
  • [ 155820-88-5 ]
  • 17
  • [ 383-62-0 ]
  • [ 5056-07-5 ]
  • [ 121898-05-3 ]
  • [ 133343-42-7 ]
  • 18
  • [ 383-62-0 ]
  • [ 5056-07-5 ]
  • [ 132164-16-0 ]
  • [ 133343-49-4 ]
  • 19
  • [ 383-62-0 ]
  • [ 15931-69-8 ]
  • [ 135217-71-9 ]
  • 20
  • [ 383-62-0 ]
  • [ 69490-70-6 ]
  • [ 162363-02-2 ]
  • 21
  • [ 383-62-0 ]
  • [ 54962-15-1 ]
  • [ 155094-65-8 ]
  • 22
  • [ 383-62-0 ]
  • [ 47562-49-2 ]
  • [ 141708-75-0 ]
  • 23
  • [ 383-62-0 ]
  • (3,3-Diethoxy-propyl)-triphenyl-phosphonium [ No CAS ]
  • [ 162363-03-3 ]
  • 24
  • [ 383-62-0 ]
  • [ 1517-82-4 ]
  • [ 136310-09-3 ]
  • 25
  • [ 383-62-0 ]
  • [ 105852-47-9 ]
  • [ 119352-51-1 ]
  • [ 119352-52-2 ]
  • 26
  • [ 383-62-0 ]
  • [ 126300-18-3 ]
  • [ 126275-27-2 ]
  • [ 126275-28-3 ]
  • 27
  • [ 383-62-0 ]
  • [ 85846-13-5 ]
  • [ 136101-45-6 ]
  • 28
  • [ 383-62-0 ]
  • [ 454-31-9 ]
YieldReaction ConditionsOperation in experiment
>= 75% With palladium on activated charcoal; hydrogen; triethylamine; In ethanol; at 30℃; under 750.075 - 3000.3 Torr; 1 part of <strong>[383-62-0]ethyl difluorochloroacetate</strong>Triethylamine 0.5 part5 parts of ethanolPalladium on carbon 0.002 partsThe preparation of the above ethyl ethyl difluoroacetate comprises the following steps:(1) 1 part of <strong>[383-62-0]ethyl difluorochloroacetate</strong>, 0.5 part of triethylamine, 5 parts of solvent ethanol and 0.002 part of palladium on carbon were successively charged in a high pressure reactor;(2) the first nitrogen replacement reactor air at least 3 times, and then replaced with hydrogen at least 3 times, slowly warming to 30 C, then the pressure in the O.IMPa around;(3) and then slowly through the hydrogen to the pressure of 0.4MPa to carry out hydrogenation reaction, when the pressure inside the kettle down to O.IMPa, again through the hydrogen to the kettle pressure 0.4MPa;(4) Repeat step (3) several times until the pot pressure is no longer falling and the reaction is over;(5) sample analysis of the reactants in the raw materials ethyl dichloroacetate content;(6) Distillation: The product obtained in step (4) is subjected to atmospheric distillation in a glass bottle, and the product is separated from ethyl difluoroacetate and solvent ethanol. The bottoms are filtered and washed with water to recover the catalyst. In the next reaction.
  • 29
  • [ 383-62-0 ]
  • [ 541-41-3 ]
  • [ 141546-96-5 ]
  • 30
  • [ 383-62-0 ]
  • [ 100-52-7 ]
  • [ 92207-60-8 ]
  • 31
  • [ 383-62-0 ]
  • [ 630-19-3 ]
  • [ 118460-38-1 ]
  • 32
  • [ 383-62-0 ]
  • [ 107-18-6 ]
  • [ 1524-26-1 ]
  • 33
  • [ 383-62-0 ]
  • [ 67373-56-2 ]
  • [ 68-12-2 ]
  • 3-Dimethylamino-3-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-2,2-difluoro-propionic acid ethyl ester [ No CAS ]
  • 35
  • [ 383-62-0 ]
  • [ 68-12-2 ]
  • [ 80-40-0 ]
  • [ 141546-96-5 ]
 

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