There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
Structure of 383-62-0
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
4.5
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Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 383-62-0 |
Formula : | C4H5ClF2O2 |
M.W : | 158.53 |
SMILES Code : | O=C(OCC)C(F)(Cl)F |
MDL No. : | MFCD00013662 |
InChI Key : | GVCAWQUJCHZRCB-UHFFFAOYSA-N |
Pubchem ID : | 67843 |
GHS Pictogram: |
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Signal Word: | Danger |
Hazard Statements: | H225-H314 |
Precautionary Statements: | P210-P280-P305+P351+P338-P310 |
Class: | 3(8) |
UN#: | 2924 |
Packing Group: | Ⅱ |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
78.5% | With toluene-4-sulfonic acid; In dichloromethane; at 20 - 33℃; for 38.5h;Heating / reflux; | (VO 504. 3 G (3. 87MOL) CHLORDIFLUORESSIGSaURE UND 5. 0 G p-Toluolsulfonsaure werden in 775 ml Methylenchlorid gelost und bei Raumtemperatur innerhalb von 30min mit 311. 6 G (6. 76 MOL) Ethanol versetzt (Temperaturanstieg auf 33oC). Man ruhrt 38 h unter Ruckfluss am Wasserabscheider nach und kuhlt auf Raumtemperatur ab. Zur Aufarbeitung wascht man mit Wasser (200 ml), gesattigter Natriumhydrogencarbonatlosung (200 ml) und erneut mit Wasser (200 ml), trocknet uber Natriumsulfat, filtriert und destilliert das Losungsmittel ab. Anschliesend wird durch fraktionierte Destillation WEITER AUFGEREINIGT ;-- Man erhalt 488.9 g (98% ig, 78.5 % der Theorie) an Chlordifluoressigsaureethylester (Siedepunkt 94- 96oC). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
>= 75% | With palladium on activated charcoal; hydrogen; triethylamine; In ethanol; at 30℃; under 750.075 - 3000.3 Torr; | 1 part of <strong>[383-62-0]ethyl difluorochloroacetate</strong>Triethylamine 0.5 part5 parts of ethanolPalladium on carbon 0.002 partsThe preparation of the above ethyl ethyl difluoroacetate comprises the following steps:(1) 1 part of <strong>[383-62-0]ethyl difluorochloroacetate</strong>, 0.5 part of triethylamine, 5 parts of solvent ethanol and 0.002 part of palladium on carbon were successively charged in a high pressure reactor;(2) the first nitrogen replacement reactor air at least 3 times, and then replaced with hydrogen at least 3 times, slowly warming to 30 C, then the pressure in the O.IMPa around;(3) and then slowly through the hydrogen to the pressure of 0.4MPa to carry out hydrogenation reaction, when the pressure inside the kettle down to O.IMPa, again through the hydrogen to the kettle pressure 0.4MPa;(4) Repeat step (3) several times until the pot pressure is no longer falling and the reaction is over;(5) sample analysis of the reactants in the raw materials ethyl dichloroacetate content;(6) Distillation: The product obtained in step (4) is subjected to atmospheric distillation in a glass bottle, and the product is separated from ethyl difluoroacetate and solvent ethanol. The bottoms are filtered and washed with water to recover the catalyst. In the next reaction. |