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Chemical Structure| 943519-37-7

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Product Details of [ 943519-37-7 ]

CAS No. :943519-37-7
Formula : C11H14O4
M.W : 210.23
SMILES Code : O=C(OC)C1=CC(C(C)C)=C(O)C=C1O
MDL No. :MFCD16037579
InChI Key :NAOCXJWZGXUTCQ-UHFFFAOYSA-N
Pubchem ID :59167875

Safety of [ 943519-37-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 943519-37-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 943519-37-7 ]

[ 943519-37-7 ] Synthesis Path-Upstream   1~3

  • 1
  • [ 912545-08-5 ]
  • [ 943519-37-7 ]
YieldReaction ConditionsOperation in experiment
100% With hydrogen In methanol; ethanol at 20℃; PREPARATION A2Methyl 2,4-dihydroxy-5-isopropylbenzoateMethyl 2,4-dihydroxy-5-isopropylbenzoate10percent Palladium on carbon (350 mg) was added to a suspension of methyl 2,4-bis- benzyloxy-5-isopropenylbenzoate [prepared as per WO 2006/109085 A1] (3.88 g, 10.0 mmol) in ethanol (30 ml) and the mixture was stirred at room temperature under a hydrogen atmosphere for 1 hour. Methanol (20 ml) was added to aid dissolution and the mixture was stirred at room temperature under a hydrogen atmosphere for 16 hours. The mixture was filtered, the catalyst was rinsed with methanol (3 x 20 ml) and the combined filtrates were evaporated in vacuo to afford methyl 2,4-dihydroxy-5-isopropylbenzoate (2.1O g, 100percent) as a colourless solid. 1H NMR (DMSO-d6) 10.54 (1 H, s), 10.44 (1 H, br s), 7.52 (1 H, s), 6.37 (1 H, s), 3.85 (3H, s), 3.08 (1 H, m), 1.13 (6H, d). MS: [M+H]+ 211.
References: [1] Patent: WO2009/125230, 2009, A1, . Location in patent: Page/Page column 102.
  • 2
  • [ 2150-47-2 ]
  • [ 75-26-3 ]
  • [ 943519-37-7 ]
YieldReaction ConditionsOperation in experiment
45% With aluminum (III) chloride In dichloromethane at 50℃; for 24 h; Inert atmosphere A mixture of compound 6 (3.9g, 23.0mmol), 2-bromopropane (4.3mL, 46.0mmol), and aluminum chloride (6.1g, 46.0mmol) in CH2Cl2 was stirred at 50°C for 24h, equipped with a refluxing condenser under argon. 2-Bromopropane (4.3mL, 46.0mmol) was added to the reaction mixture three times every 6h. The mixture was neutralized with 10percent NaOH to pH 5, concentrated under reduced pressure, and then extracted with ethyl aceatate. The organic layer was washed with saturated NaHCO3 solution three times, dried over Na2SO4, concentrated under reduced pressure, and purified by column to afford compound 16 in 45percent yield. Rf=0.21 (1:4 ethyl acetate: hexane). 1H NMR (400MHz, CDCl3) δ 10.8 (s, 1H), 7.64 (s, 1H), 6.34 (s, 1H), 5.50 (s, 1H), 3.90 (s, 3H), 3.15–3.08 (m, 1H), 1.25 (d, J=10.8Hz, 6H). 13C NMR (100MHz, CDCl3) δ 170.7, 161.6, 159.6, 128.1, 127.1, 105.7, 103.2, 52.2, 26.7, 22.8.
45% With aluminum (III) chloride In dichloromethane at 50℃; for 24 h; Inert atmosphere Compound 7 was synthesized in the same manner as in Reaction Scheme 1 above.Compound 6 (3.9 g, 23.0 mmol), 2-bromopropane (4.3 mL, 46.0 mmol) and aluminum chloride (6.1 g, 46.0 mmol) were added in CH2Cl2 and stirred in a reflux condenser at 50 C for 24 hours under argon.2-Bromopropane (4.3 mL, 46.0 mmol) was added to the reaction mixture three times every 6 hours. The mixture was then neutralized by the addition of 10percent NaOH (pH 5), concentrated under reduced pressure and extracted with ethyl acetate.The organic layer was washed three times with saturated NaHCO3 solution, dried over Na2SO4 and concentrated under reduced pressure. The concentrate was then purified by silica gel chromatography to give compound 7 in 45percent yield.
45% With aluminum (III) chloride In dichloromethane at 50℃; for 30 h; Methylene chloride (CH2Cl2), the compound 4 (3.9 g, 23.0 mmol), 2-bromopropane (4.3 mL, 46.00 mmol) and aluminum chloride (6.1 g, , 46.0 mmol) were added and stirred at 50 ° C for 24 hours. 4.3 mL (46.0 mmol) of 2-bromopropane was then added to the reaction mixture three times for a total of 6 hours. The mixture was neutralized with 10percent sodium hydroxide until the pH reached 5, concentrated in a reduced pressure environment and extracted with ethyl acetate. The organic layer was washed three times with saturated NaHCO3 solution, dried in the presence of Na2SO4 and concentrated again under reduced pressure. It was then purified on a silica gel column to give compound 5 with a yield of 45percent. Rf = 0.21 (1: 4 ethyl acetate: hexane).
45% With aluminum (III) chloride In dichloromethane at 50℃; for 24 h; Inert atmosphere; Microwave irradiation 21.
Methyl 2,4-dihydroxy-5-isopropylbenzoate (12)
Compound 6 (3.9 g, 23.0 mmol), 2-bromopropane (4.3 mL, 46.0 mmol) and aluminum chloride (6.1 g, 46.0 mmol) were dissolved in CH2Cl2 and then stirred under argon at 50° C. for 24 hours with a reflux condenser under a microwave irradiation (Biotage Initiator).
3-Bromopropane (4.3 ml, 46.0 mmol) was added to the reaction mixture three times every 6 hours.
The mixture was neutralized with 10percent NaOH to pH 5, concentrated under pressure and extracted with ethyl acetate.
The organic layer was washed with saturated NaHCO3 solution three times, dried over Na2SO4, concentrated under pressure and purified by column to obtain Compound 12 in a yield of 45percent.
Rf=0.21 (1:4 ethyl acetate:hexane).
1H NMR (400 MHz, CDCl3) δ 10.8 (s, 1H), 7.64 (s, 1H), 6.34 (s, 1H), 5.53 (s, 1H), 3.92 (s, 3H), 3.15-3.08 (m, 1H), 1.25 (d, J=10.8 Hz, 6H).
13C NMR (100 MHz, CDCl3) δ 170.7, 161.6, 159.6, 128.1, 127.1, 105.7, 103.2, 52.2, 26.7, 22.8

References: [1] European Journal of Medicinal Chemistry, 2016, vol. 124, p. 1069 - 1080.
[2] Patent: KR101641829, 2016, B1, . Location in patent: Paragraph 0043-0044; 0051-0055.
[3] Patent: KR101789269, 2017, B1, . Location in patent: Paragraph 0046; 0048; 0054; 0055.
[4] Patent: US2019/31620, 2019, A1, . Location in patent: Paragraph 0190; 0191; 0192; 0193; 0194; 0290; 0291; 0292.
[5] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 390 - 401.
  • 3
  • [ 89-86-1 ]
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References: [1] European Journal of Medicinal Chemistry, 2016, vol. 124, p. 1069 - 1080.
[2] Patent: KR101641829, 2016, B1, .
[3] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 390 - 401.
[4] Patent: KR101789269, 2017, B1, .
[5] Patent: US2019/31620, 2019, A1, .
 

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