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Chemical Structure| 943442-82-8 Chemical Structure| 943442-82-8

Structure of 943442-82-8

Chemical Structure| 943442-82-8

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Product Details of [ 943442-82-8 ]

CAS No. :943442-82-8
Formula : C14H9FN4O2
M.W : 284.25
SMILES Code : O=C(C1=CN2C(C=C1)=NC=N2)C(C3=NC(C)=C(F)C=C3)=O

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Application In Synthesis of [ 943442-82-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 943442-82-8 ]

[ 943442-82-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 3382-18-1 ]
  • [ 943442-82-8 ]
  • C23H17FN6 [ No CAS ]
YieldReaction ConditionsOperation in experiment
17% Example 11:; [001861 A mixture of l-(5-fluoro-6-methyl-pyridm-2-yl)-2-[l,2,4]triazolo[l,5-a]pyridin-6- yl-ethane-l,2-dione (0.552 g, 0.00194 mol), 3,4-dihydro-isoquinoline (0.3 g, 0.002 mol) , ammonium acetate (0.627 g, 0.008 mol) and acetic acid (1.57 mL, 0.0276 mol) in 7 mL of 2- methoxy-2-methylpropane was refhαxed for 15 hours. Additional (0.3 g, 0.001 mol) diketone was added and the reaction mixture refluxed for 2 hours. After cooling to room temperature, the mixture was partitioned between CH2Cl2 and a saturated aqueous solution OfNa2CO3. The organic phases were dried over MgSO4, filtered and concentrated under vacuum. The resulting crude material that was purified by reverse phase preparative HPLC. Fractions containing the product by LC-MS were combined, concentrated and partitioned between CH2CI2 and a saturated aqueous solution OfNa2CO3. The organic phase was dried over MgSO4, filtered and concentrated under vacuum and triturated with Et2O to afford the title compound as a white solid (0.130 g, 17%).1H-NMR (300 MHz, CDCl3): 8.91 (s, IH), 8.44 (m, IH), 8.25 (m, broad, IH), 7.92 (m, broad, IH), 7.83 (dd, IH, J = 9 Hz, 2.8 Hz), 7.67-7.64 (m, IH), 7.44-7.27 (m, 4H), 4.12 (t, 2H, J = 6.5 Hz), 3.2 (t, 2H, J= 6.5Hz), 2.27 (d, 3H, J= 2.5 Hz). MS (ES+) m/z 396 [M+].
 

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