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Chemical Structure| 94226-55-8 Chemical Structure| 94226-55-8

Structure of 94226-55-8

Chemical Structure| 94226-55-8

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Product Details of [ 94226-55-8 ]

CAS No. :94226-55-8
Formula : C17H19NO2
M.W : 269.34
SMILES Code : O=C(OC)CN(CC1=CC=CC=C1)CC2=CC=CC=C2
MDL No. :MFCD02668205

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Application In Synthesis of [ 94226-55-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 94226-55-8 ]

[ 94226-55-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 94226-55-8 ]
  • [ 925-90-6 ]
  • [ 428855-17-8 ]
YieldReaction ConditionsOperation in experiment
With titanium(IV) isopropylate; magnesium; In diethyl ether; at 15 - 20℃;Inert atmosphere; To a solution of methyl 2-(dibenzylamino)acetate (20.0 g, 74.3 mmol) in dry diethyl ether (250 ml) under a stream of argon was added dropwise a solution of titanium tetraisopropoxide (5.28 g, 18.6 mmol, 5.5 mL) in diethyl ether (50 mL). Ethylmagnesium bromide in diethyl ether (1M solution freshly prepared from bromoethane (24.3 g, 222 mmol,16.6 mL) and magnesium (5.69 g, 234 mmol) was added dropwise at 15-20C under Ar. The reaction mixture was stirred overnight, then cooled to 0C and quenched by dropwise addition of sat. aq. NH4C1 solution (300 mL). The reaction mixture was stirred at r.t. for 2 h and filtered. The organic phase was separated and the aqueous phase was extracted with MTBE (100 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated to afford crude 1-[(diben.zylamino)methyl]cyclopropan-1-ol (17.5 g, 50.0% purity, 32.73 mmol, 44% yield) as yellow oil, that was used in the next step without purification.
 

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