942190-61-6|1-tert-Butyl 3-methyl 3-hydroxypyrrolidine-1,3-dicarboxylate| Ambeed

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Quality Control of [ 942190-61-6 ] Purity: 97% SDS Specification

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Product Details of [ 942190-61-6 ]

CAS No. :	942190-61-6
Formula :	C₁₁H₁₉NO₅
M.W :	245.27
SMILES Code :	O=C(N1CC(C(OC)=O)(O)CC1)OC(C)(C)C
MDL No. :	MFCD12400943
InChI Key :	ALAIMDFVDAWVMO-UHFFFAOYSA-N
Pubchem ID :	42609292

Safety of [ 942190-61-6 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335-H412
Precautionary Statements:	P261-P273-P305+P351+P338

Computational Chemistry of [ 942190-61-6 ] Show Less

Physicochemical Properties

Num. heavy atoms	17
Num. arom. heavy atoms	0
Fraction Csp3	0.82
Num. rotatable bonds	5
Num. H-bond acceptors	5.0
Num. H-bond donors	1.0
Molar Refractivity	63.88
TPSA ? Topological Polar Surface Area: Calculated from Ertl P. et al. 2000 J. Med. Chem.	76.07 Å²

Lipophilicity

Log P_o/w (iLOGP)? iLOGP: in-house physics-based method implemented from Daina A et al. 2014 J. Chem. Inf. Model.	2.53
Log P_o/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by XLOGP program, version 3.2.2, courtesy of CCBG, Shanghai Institute of Organic Chemistry	0.34
Log P_o/w (WLOGP)? WLOGP: Atomistic method implemented from Wildman SA and Crippen GM. 1999 J. Chem. Inf. Model.	0.15
Log P_o/w (MLOGP)? MLOGP: Topological method implemented from Moriguchi I. et al. 1992 Chem. Pharm. Bull. Moriguchi I. et al. 1994 Chem. Pharm. Bull. Lipinski PA. et al. 2001 Adv. Drug. Deliv. Rev.	0.22
Log P_o/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	0.29
Consensus Log P_o/w? Consensus Log P_o/w: Average of all five predictions	0.71

Water Solubility

Log S (ESOL):? ESOL: Topological method implemented from Delaney JS. 2004 J. Chem. Inf. Model.	-1.24
Solubility	14.0 mg/ml ; 0.0569 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Very soluble
Log S (Ali)? Ali: Topological method implemented from Ali J. et al. 2012 J. Chem. Inf. Model.	-1.5
Solubility	7.73 mg/ml ; 0.0315 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Very soluble
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	-0.72
Solubility	46.5 mg/ml ; 0.19 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble

Pharmacokinetics

GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg	High
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg	No
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) and tested on 415 molecules (test set) 10-fold CV: ACC=0.72 / AUC=0.77 External: ACC=0.88 / AUC=0.94	No
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.83 / AUC=0.90 External: ACC=0.84 / AUC=0.91	No
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.80 / AUC=0.86 External: ACC=0.80 / AUC=0.87	No
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) and tested on 2075 molecules (test set) 10-fold CV: ACC=0.78 / AUC=0.85 External: ACC=0.71 / AUC=0.81	No
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) and tested on 1068 molecules (test set) 10-fold CV: ACC=0.79 / AUC=0.85 External: ACC=0.81 / AUC=0.87	No
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) and tested on 2579 molecules (test set) 10-fold CV: ACC=0.77 / AUC=0.85 External: ACC=0.78 / AUC=0.86	No
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from Potts RO and Guy RH. 1992 Pharm. Res.	-7.55 cm/s

Druglikeness

Lipinski? Lipinski (Pfizer) filter: implemented from Lipinski CA. et al. 2001 Adv. Drug Deliv. Rev. MW ≤ 500 MLOGP ≤ 4.15 N or O ≤ 10 NH or OH ≤ 5	0.0
Ghose? Ghose filter: implemented from Ghose AK. et al. 1999 J. Comb. Chem. 160 ≤ MW ≤ 480 -0.4 ≤ WLOGP ≤ 5.6 40 ≤ MR ≤ 130 20 ≤ atoms ≤ 70	None
Veber? Veber (GSK) filter: implemented from Veber DF. et al. 2002 J. Med. Chem. Rotatable bonds ≤ 10 TPSA ≤ 140	0.0
Egan? Egan (Pharmacia) filter: implemented from Egan WJ. et al. 2000 J. Med. Chem. WLOGP ≤ 5.88 TPSA ≤ 131.6	0.0
Muegge? Muegge (Bayer) filter: implemented from Muegge I. et al. 2001 J. Med. Chem. 200 ≤ MW ≤ 600 -2 ≤ XLOGP ≤ 5 TPSA ≤ 150 Num. rings ≤ 7 Num. carbon > 4 Num. heteroatoms > 1 Num. rotatable bonds ≤ 15 H-bond acc. ≤ 10 H-bond don. ≤ 5	0.0
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat implemented from Martin YC. 2005 J. Med. Chem.	0.55

Medicinal Chemistry

PAINS? Pan Assay Interference Structures: implemented from Baell JB. & Holloway GA. 2010 J. Med. Chem.	0.0 alert
Brenk? Structural Alert: implemented from Brenk R. et al. 2008 ChemMedChem	1.0 alert: heavy_metal
Leadlikeness? Leadlikeness: implemented from Teague SJ. 1999 Angew. Chem. Int. Ed. 250 ≤ MW ≤ 350 XLOGP ≤ 3.5 Num. rotatable bonds ≤ 7	No; 1 violation:MW<1.0
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) based on 1024 fragmental contributions (FP2) modulated by size and complexity penaties, trained on 12'782'590 molecules and tested on 40 external molecules (r² = 0.94)	3.01

Application In Synthesis of [ 942190-61-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 942190-61-6 ]

[ 942190-61-6 ] Synthesis Path-Downstream 1~24

1
[ 67-56-1 ]
[ 24424-99-5 ]
[ 942190-61-6 ]

Yield	Reaction Conditions	Operation in experiment
71%		A mixture of compound 2W (5.3 g, 25 mmol), MeOH (50 ml), 4N solution of HCI in dioxane (10 ml) was heated in a sealed tube at 70 0C for overnight. The reaction mixture was concentrated and THF (20 ml) was added followed by CH2CI2 (50 ml), triethylamine (16 ml) and di-tert-butyl dicarbonate (11g). The reaction mixture was stirred at room temperature for overnight and then concentrated. Diluted the residue with ether (200 ml) and washed with water (100 ml). The organic layer was separated, dried over Na2SO4, filtered and concentrated. The residue was purified on silica gel eluting with 1/1 EtOAc/hexane then 2/1 EtOAC/hexane to give the desired product 3W (4.35 g, 71%).

References: [1]Patent: WO2007/70398,2007,A1 .Location in patent: Page/Page column 440.

2
[ 942190-61-6 ]
[ 57842-27-0 ]
[ 942190-62-7 ]

Yield	Reaction Conditions	Operation in experiment
61%	With pyridine; In dichloromethane; at 20℃; for 120h;	To a solution of compound 3W (2.8 g, 11.4 mmol) in CH2CI2 (100 ml) was added 1 ,3-ben2:odithiol-2-yIium tetrafluoroborate (5.4 g, 22.8 mmol) followed by pyridine (0.2 ml). The reaction mixture was stirred at room temperature for five days. Quenched the reaction mixture with triethylamine (9.6 ml) and stirred for 15 minutes. The reaction mixture was washed with water (100 ml), dried over Na2SO4, filtered and <n="443"/>concentrated. The residue was purified on silica gel eluting with 1/4 EtOAc/hexane then 1/2 EtOAC/hexane to give the desired product 4W (2.75 g, 61%).

References: [1]Patent: WO2007/70398,2007,A1 .Location in patent: Page/Page column 440-441.

3
[ 942190-61-6 ]
[ 74-88-4 ]
1-(tert-butyl) 3-methyl 3-methoxypyrrolidine-1,3-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
0.23 g	With caesium carbonate; In acetonitrile; at 80℃; for 20h;	Step c. To a solution of methyl 1 -(tert-butyl) 3-methyl 3-hydroxypyrrolidine-l,3- dicarboxylate (0.27 g, 1.10 mmol) in MeCN (10 ml) was added Cs2C03 (1.79 g, 5.51 mmol) at rt. The reaction mixture was stirred at rt for 5 min. CI (0.78 g, 5.51 mmol) was added to the reaction mixture at rt. The reaction mixture was heated at 80C for 20 h. The resulting reaction mixture was poured into cold water (15 ml) and extracted with EtOAc (3 x 10 ml). The combined organic phase was collected, dried over Na2SC>4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography (10% EtOAc in hexane) yielding 1 -(tert-butyl) 3-methyl 3-methoxypyrrolidine-l,3-dicarboxylate (0.23 g, 0.88 mmol). LCMS: Method A, 2.13 min, MS: ES+ 260.30.
		To a solution of <strong>[942190-61-6]1-(tert-butyl) 3-methyl 3-hydroxypyrrolidine-1,3-dicarboxylate</strong> (250 mg, 1.02mmol) in DMF (5 mL) was added NaH (81.53 mg, 2.04 mmol) at 0C. The reaction was stirredfor 10 mm, and methyl iodide (434 mg, 3.06 mmol) was added. The resulting mixture was stirred at 28C for 3 h. The mixture was poured into water (20 mL) and extracted with EtOAc (3 x 30 mL). The organic layer was washed with brine (3 x 20 mL), dried over Na2SO4, filtered and concentrated to provide 1 -(tert-butyl) 3-methyl 3-methoxypyrrolidine- 1,3 -dicarboxylate whichwas used without purification.

References: [1]Patent: WO2016/46530,2016,A1 .Location in patent: Page/Page column 86-87.
[2]Patent: WO2019/74809,2019,A1 .Location in patent: Page/Page column 35.

4
[ 24424-99-5 ]
methyl 3-hydroxypyrrolidine-3-carboxylate hydrochloride [ No CAS ]
[ 942190-61-6 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydrogencarbonate; In water; ethyl acetate; at 20℃; for 8h;	Step b. To the suspension of methyl 3-hydroxypyrrolidine-3-carboxylate HC1 (0.55 g, 3.03 mmol) in sat. NaHCOs solution (2 ml) and EtOAc (5 ml) was added BOC anhydride (1.32 g, 6.07 mmol) and stirred at rt for 8 h. The resulting reaction mixture was poured into water (15 ml) and extracted with EtOAc (3 x 10 ml). The combined organic phase was collected, dried over Na2S04, filtered and concentrated under reduced pressure yielding l-(tert-butyl) 3- methyl 3-hydroxypyrrolidine-l,3-dicarboxylate (0.29 g, 1.18 mmol). This material was used directly for the next step without further purification. LCMS: Method A, 1.88 min, MS: ES+ 246.30.
2.2 g	With sodium hydrogencarbonate; In ethyl acetate; at 20℃; for 16h;	To a stirred solution of methyl 3-hydroxypyrrolidine-3-carboxylate HC1 salt (4.2 g, 23.204 mmol) in EtOAc (42 ml) was added saturated NaHC03solution (42 ml) at rt. Boc anhydride (10.12 g, 46.4 mmol) was added to the reaction mixture at rt. The reaction mixture was stirred at rt for 16 h. The resulting reaction mixture was poured into saturated NaHC03(200 ml) and extracted with EtOAc (2 x 100 ml). The combined organic phase was dried over Na2S0 , filtered and concentrated under reduced pressure. The resulting residue was purified by flash chromatography (30% EtOAc in hexane) yielding 1 -(tert-butyl) 3-methyl 3-hydroxypyrrolidine-l,3-dicarboxylate (2.2 g, 8.979 mmol). LCMS: Method 1, 1.90 min, MS: ES+ 246.2; NMR (400 MHz, DMSO-d6) delta ppm: 5.87 (s, 1 H), 3.68 (s, 3 H), 3.41 - 3.52 (m, 2 H), 3.28 - 3.32 (M, 2 H), 2.09 - 2.18 (m, 1 H), 1.91 - 1.94 (m, 1 H), 1.39 (s, 9 H).

References: [1]Patent: WO2016/46530,2016,A1 .Location in patent: Page/Page column 86.
[2]Patent: WO2017/149313,2017,A1 .Location in patent: Page/Page column 48; 49.

5
[ 1194376-31-2 ]
[ 942190-61-6 ]

References: [1]Patent: WO2016/46530,2016,A1 .

6
[ 942190-61-6 ]
1-(tert-butoxycarbonyl)-3-methoxypyrrolidine-3-carboxylic acid [ No CAS ]

References: [1]Patent: WO2016/46530,2016,A1 .

7
[ 942190-61-6 ]
tert-butyl 7-bromo-2-oxo-1,2-dihydrospiro[pyrido[2,3-b][1,4]oxazine-3,3'-pyrrolidine]-1'-carboxylate [ No CAS ]

References: [1]Patent: WO2017/149313,2017,A1 .

8
[ 942190-61-6 ]
tert-butyl 7-bromo-2-oxo-1,2-dihydrospiro[pyrido[2,3-b][1,4]oxazine-3,3'-pyrrolidine]-1'-carboxylate [ No CAS ]
1-(tert-butyl) 3-methyl 3-((3-amino-5-bromopyridin-2-yl)oxy)pyrrolidine-1,3-dicarboxylate [ No CAS ]

References: [1]Patent: WO2017/149313,2017,A1 .

9
[ 942190-61-6 ]
tert-butyl 2-oxo-1,2-dihydrospiro[pyrido[2,3-b][1,4]oxazine-3,3'-pyrrolidine]-1'-carboxylate [ No CAS ]

References: [1]Patent: WO2017/149313,2017,A1 .

10
[ 942190-61-6 ]
spiro[pyrido[2,3-b][1,4]oxazine-3,3'-pyrrolidin]-2(1H)-one trifluoroacetic acid [ No CAS ]

References: [1]Patent: WO2017/149313,2017,A1 .

11
[ 942190-61-6 ]
tert-butyl 2-oxo-7-phenyl-1,2-dihydrospiro[pyrido[2,3-b][1,4]oxazine-3,3'-pyrrolidine]-1'-carboxylate [ No CAS ]

References: [1]Patent: WO2017/149313,2017,A1 .
[2]Patent: WO2017/149313,2017,A1 .

12
[ 942190-61-6 ]
7-phenylspiro[pyrido[2,3-b][1,4]oxazine-3,3'-pyrrolidin]-2(1H)-one trifluoroacetic acid [ No CAS ]

References: [1]Patent: WO2017/149313,2017,A1 .
[2]Patent: WO2017/149313,2017,A1 .

13
[ 942190-61-6 ]
(S)-2-oxo-7-phenyl-1,2-dihydrospiro[pyrido[2,3-b][1,4]oxazine-3,3'-pyrrolidine]-1'-carbonitrile [ No CAS ]
(R)-2-oxo-7-phenyl-1,2-dihydrospiro[pyrido[2,3-b][1,4]oxazine-3,3'-pyrrolidine]-1'-carbonitrile [ No CAS ]

References: [1]Patent: WO2017/149313,2017,A1 .
[2]Patent: WO2017/149313,2017,A1 .

14
[ 942190-61-6 ]
1-(tert-butyl) 3-methyl 3-((2-aminobenzyl)oxy)pyrrolidine-1,3-dicarboxylate [ No CAS ]

References: [1]Patent: WO2017/149313,2017,A1 .

15
[ 942190-61-6 ]
tert-butyl 2-oxo-1,5-dihydro-2H-spiro[benzo[e][1,4]oxazepine-3,3'-pyrrolidine]-1'-carboxylate [ No CAS ]

References: [1]Patent: WO2017/149313,2017,A1 .

16
[ 942190-61-6 ]
1,5-dihydro-2H-spiro[benzo[e][1,4]oxazepine-3,3'-pyrrolidin]-2-one trifluoroacetic acid [ No CAS ]

References: [1]Patent: WO2017/149313,2017,A1 .

17
[ 942190-61-6 ]
2-oxo-1,2-dihydrospiro[pyrido[2,3-b][1,4]oxazine-3,3'-pyrrolidine]-1'-carbonitrile [ No CAS ]

References: [1]Patent: WO2017/149313,2017,A1 .

18
[ 942190-61-6 ]
2-oxo-7-phenyl-1,2-dihydrospiro[pyrido[2,3-b][1,4]oxazine-3,3'-pyrrolidine]-1'-carbonitrile [ No CAS ]

References: [1]Patent: WO2017/149313,2017,A1 .
[2]Patent: WO2017/149313,2017,A1 .

19
[ 942190-61-6 ]
2-oxo-1,5-dihydro-2H-spiro[4,1-benzo[e][1,4]oxazepine-3,3'-pyrrolidine]-1'-carbonitrile [ No CAS ]

References: [1]Patent: WO2017/149313,2017,A1 .

20
[ 942190-61-6 ]
2-fluoro-3-nitro-5-bromopyridine [ No CAS ]
1-(tert-butyl) 3-methyl 3-((5-bromo-3-nitropyridin-2-yl)oxy)pyrrolidine-1,3-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1.65 g		To a stirred solution of 1 -(tert-butyl) 3-methyl 3-hydroxypyrrolidine-l,3-dicarboxylate (Intermediate C; 0.5 g, 2.04 mmol) in THF (30 ml) was added sodium bis(trimethylsilyl)amide solution (1M in THF; 2.04 ml, 2.04 mmol) dropwise at -78C. The reaction mixture was stirred at - 78C for 5 min. A solution of 2-fluoro-3-nitro-5-bromopyridine (CAS Number 886372-98-1; 0.493 g, 2.24 mmol) in THF (1 ml) was added to the reaction mixture at -78C. The reaction mixture was stirred at -78C to -40C for 5 h. The resulting reaction mixture was quenched by slow addition of saturated ammonium chloride solution (20 ml) at -40C. The resulting reaction mixture was warmed to rt and combined with three other batches on the same scale prepared by an identical method. The reaction mixture was diluted with water (50 ml) and extracted with EtOAc (3 x 50 ml). The combined organic phase was separated and washed with brine (30 ml). The organic phase was separated, dried over Na2S04, filtered and concentrated under reduced pressure. The resulting residue was purified by flash chromatography (12% EtOAc in hexane) yielded 1 -(tert-butyl) 3-methyl 3-((5-bromo-3- nitropyridin-2-yl)oxy)pyrrolidine-l,3-dicarboxylate (1.65 g, 3.697 mmol). LCMS: Method 1, 2.539 min, MS: ES+ 390.2, 392.2 (M-2) (M-56); 1HNMR (400 MHz, DMSO-d6) delta ppm: 8.78 (s, 1 H), 8.63 (s, 1 H), 4.00 (d, J=12.0 Hz, 1 H), 3.70 (d, J=12.8 Hz, 1 H), 3.65 (s, 3 H), 3.48 - 3.54 (m, 1 H), 3.37 - 3.46 (m, 1 H), 2.39 - 2.45 (m, 2 H), 1.39 (d, J=6.4 Hz, 9 H).

References: [1]Patent: WO2017/149313,2017,A1 .Location in patent: Page/Page column 49.

21
[ 942190-61-6 ]
[ 3958-60-9 ]
1-(tert-butyl) 3-methyl 3-((2-nitrobenzyl)oxy)pyrrolidine-1,3-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
0.13 g	With potassium carbonate; In N,N-dimethyl-formamide; at 20℃; for 16h;	To a solution of l-(tert-butyl) 3-methyl 3-hydroxypyrrolidine-l,3-dicarboxylate (Intermediate C, 0.7 g, 2.857 mmol) in DMF (10 ml) were added K2C03(1.18 g, 8.571 mmol) and 2-nitrobenzyl bromide (CAS Number 3958-60-9; 0.74 g, 3.428 mmol) at rt. The reaction mixture was stirred at rt for 16 h then poured into water (150 ml) and extracted with EtOAc (3 x 100 ml). The combined organic phase was separated, dried over Na2S04, filtered and concentrated under reduced pressure. The resulting residue was purified by flash chromatography (neutral aluminium oxide, 5% EtOAc in hexane) yielding l-(tert-butyl) 3-methyl 3-((2-nitrobenzyl)oxy)pyrrolidine-l,3- dicarboxylate (0.13 g, 0.342 mmol). LCMS: Method 1, 2.557 min, MS: ES+ 325.5 (M-56); 1H NMR (400 MHz, DMSO-d6) delta ppm: 8.04 (d, J=8.0 Hz, 1 H), 7.76 (d, J=4.0 Hz, 2 H), 7.57 - 7.60 (m, 1 H), 4.78 - 4.91 (m, 2 H), 3.71 (s, 3 H), 3.58 - 3.61 (m, 2 H), 3.41 - 3.48 (m, 1 H), 3.33 - 3.35 (m, 1 H), 2.26 - 2.28 (m, 2 H), 1.38 (d, J=13.6 Hz, 9 H).

References: [1]Patent: WO2017/149313,2017,A1 .Location in patent: Page/Page column 97; 98.

22
[ 5470-18-8 ]
[ 942190-61-6 ]
1-(tert-butyl) 3-methyl 3-((3-nitropyridin-2-yl)oxy)pyrrolidine-1,3-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
0.12 g	With caesium carbonate; In N,N-dimethyl-formamide; at 60℃; for 16h;	To a stirred solution of 2-chloro-3-nitropyridine (CAS Number 5470-18-8; 0.5 g, 3.154 mmol) in DMF (10 ml) was added l-(tert-butyl) 3-methyl 3-hydroxypyrrolidine-l,3-dicarboxylate (Intermediate C; 0.62 g, 2.524 mmol) and Cs2C03(3.08 g, 9.463 mmol) at rt. The reaction mixture was stirred at 60C for 16 h. The resulting reaction mixture was poured into ice cold water (100 ml) and extracted with EtOAc (2 x 70 ml). The combined organic phase was dried over Na2S04, filtered and concentrated under reduced pressure. The resulting residue was purified by flash chromatography using neutral alumina (25% EtOAc in hexane) yielding l-(tert-butyl) 3-methyl 3-((3-nitropyridin-2- yl)oxy)pyrrolidine-l,3-dicarboxylate (0.12 g, 0.327 mmol). LCMS: Method 1, 2.20 min, MS: ES+ 368.5; 1H NMR (400 MHz, DMSO-d6) delta ppm: 8.51 (d, J=8.0 Hz, 1 H), 8.44 (dd, J=1.6 Hz, 4.8 Hz, 1 H), 7.30 -7.34 (m, 1 H), 3.97 - 4.04 (m, 1 H), 3.68 - 3.71 (m, 1 H), 3.63 (s, 3 H), 3.44 - 3.48 (m, 2 H), 2.41 - 2.45 (m, 2 H), 1.38 (s, 9 H).

References: [1]Patent: WO2017/149313,2017,A1 .Location in patent: Page/Page column 71.

23
[ 942190-61-6 ]
tert-butyl 3-(2-hydroxypropan-2-yl)-3-methoxypyrrolidine-1-carboxylate [ No CAS ]

References: [1]Patent: WO2019/74809,2019,A1 .

24
[ 942190-61-6 ]
C₈H₁₇NO₂*C₂HF₃O₂ [ No CAS ]

References: [1]Patent: WO2019/74809,2019,A1 .

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P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 942190-61-6

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CAS No.: 942190-61-6

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