Home Cart Sign in  
Chemical Structure| 939979-43-8 Chemical Structure| 939979-43-8

Structure of 939979-43-8

Chemical Structure| 939979-43-8

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 939979-43-8 ]

CAS No. :939979-43-8
Formula : C7H5Cl2N3
M.W : 202.04
SMILES Code : CC1=C2N=C(Cl)C=C(Cl)N2N=C1
MDL No. :MFCD10000839
Boiling Point : No data available
InChI Key :SHZDPXWKNQJIMX-UHFFFAOYSA-N
Pubchem ID :49761309

Safety of [ 939979-43-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H320-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 939979-43-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 939979-43-8 ]

[ 939979-43-8 ] Synthesis Path-Downstream   1~4

  • 2
  • 3-methylpyrazolo[1,5-a]pyrimidine-5,7-diol [ No CAS ]
  • [ 939979-43-8 ]
YieldReaction ConditionsOperation in experiment
400 mg With trichlorophosphate; at 110.0℃; for 3.0h; A solution of 3-methylpyrazolo[l,5-a]pyrimidine-5,7-diol (500 mg, 3.03 mmol, 1 eq) in POCb (5 mL) was stirred at 110 C for 3 h. The reaction mixture was concentrated under reduced pressure. The residue was diluted DCM (20 mL x 2) and concentrated under reduced pressure. The residue was diluted DCM (20 mL), adjusted to pH to 9-10 with DIEA and concentrated under reduced pressure to yield a residue which was purified on silica gel column chromatography (from PE/EtOAc = 1/0 to 5/1, TLC: PE/EtOAc = 10/1, Rf = 0.68) to yield product of 5,7-dichloro-3- methyl-pyrazolo[l,5-a]pyrimidine (400 mg, 1.98 mmol, 65.3% yield, 99.8% purity) as a white solid. NMR (400 MHz, CDCb) delta ppm 8.09 (s, 1H), 6.93 (s, 1H), 2.37 (s, 3H); ES-LCMS m/z 202.0, 204.0 [M+H]+.
  • 3
  • [ 939979-43-8 ]
  • 7-(5-fluoro-3-pyridyl)-N-[2-(1H-indol-3-yl)ethyl]-3-methylpyrazolo[1,5-a]pyrimidin-5-amine dihydrochloride [ No CAS ]
  • 4
  • [ 939979-43-8 ]
  • [ 872041-86-6 ]
  • 5-chloro-7-(5-fluoro-3-pyridyl)-3-methylpyrazolo[1,5-a]pyrimidine [ No CAS ]
YieldReaction ConditionsOperation in experiment
52.7% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,4-dioxane; water; at 110.0℃; for 1.0h;Microwave irradiation; Sealed tube; 5,7-Dichloro-3-methyl-pyrazolo[l,5-a]pyrimidine (190 mg, 938.52 mupiiotaomicron, 1 eq), (5-fluoro-3- pyridyl)boronic acid (138.86 mg, 985.45 muiotaetaomicron, 1.05 eq), Pd(dppf)Cl2 (68.67 mg, 93.85 muiotaetaomicron, 0.1 eq) and Cs2C03 (611.58 mg, 1.88 mmol, 2 eq) were taken up into a microwave tube in 1,4-dioxane (3 mL) and H20 (1 mL). The sealed tube was heated at 110 C for 1 h under microwave. The mixture was concentrated and water (10 mL) was added. The mixture was extracted with EtOAc (20 mL x 3). The combined organic layers were dried over Na2S04, filtered and concentrated to yield a residue which was purified on silica gel column chromatography (from PE/EtOAc = 1/0 to 10/3, TLC: PE/EtOAc = 3/1, Rf = 0.50) to yield 5-chloro-7-(5-fluoro-3-pyridyl)-3-methyl- pyrazolo[l,5-a]pyrimidine (130 mg, 494.92 mupiiotaomicron, 52.7% yield, 100.0%) purity) as a yellow solid. NMR (400 MHz, CDC13) delta ppm 8.97 (s, 1H), 8.69 (d, J = 2.7 Hz, 1H), 8.38-8.31 (m, 1H), 8.04 (s, 1H), 6.92 (s, 1H), 2.40 (s, 3H); ES-LCMS m/z 263.0, 265.0 [M+H]+.
 

Historical Records

Technical Information

Categories