Home Cart Sign in  
Chemical Structure| 937263-42-8 Chemical Structure| 937263-42-8

Structure of 937263-42-8

Chemical Structure| 937263-42-8

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 937263-42-8 ]

CAS No. :937263-42-8
Formula : C14H13N3O
M.W : 239.27
SMILES Code : NC1=CC=C(OC2=CC3=NC=CN3C=C2)C(C)=C1
MDL No. :MFCD13177248

Safety of [ 937263-42-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 937263-42-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 937263-42-8 ]

[ 937263-42-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 98556-31-1 ]
  • [ 937263-42-8 ]
  • N-(4-(imidazo[1,2-a]pyridin-7-yloxy)-3-methylphenyl)-6-iodoquinazolin-4-amine hydrochloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
24% In isopropyl alcohol; at 80℃; for 4h; Step C: Preparation of N-(4-(H-imidazo[1,2-a]pyridin-7-yloxy)-3-methylphenyl)-6-iodoquinazolin-4-amine hydrochloride: To a solution of <strong>[98556-31-1]4-chloro-6-iodoquinazoline</strong> (6.07 g, 20.9 mmol) in isopropanol (83 mL) was added 4-(H-imidazo[1,2-a]pyridin-7-yloxy)-3-methylbenzenamine (5.00 g, 20.9 mmol). After heating to 80 C for 4 hours, the mixture was cooled to room temperature and filtered. The solid was washed with cold isopropanol and recrystallized from isopropanol to provide the product (2.66 g, 24%) as yellow solid.
  • 2
  • [ 937263-42-8 ]
  • [ 56844-12-3 ]
  • [ 937263-60-0 ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; isopropyl alcohol; at 60℃; for 64h; Step C: Preparation of N-(4-(H-imidazo[1,2-a]pyridin-7-yloxy)-3-methylpheal)-6-broLnothieno[2,3-d]pyrimidin-4-amine: To a solution of <strong>[56844-12-3]6-bromo-4-chlorothieno[2,3-d]pyrimidine</strong> (0.569 g, 2.58 mmol) and 4-(H-imidazo[1,2-a]pyridin-7-yloxy)-3-methylbenzenamine (0.60 g, 2.51 mmol) in dichloroethane/isopropanol (11 mL) was added DIEA (0.44 mL, 2.51 mmol). After heating to 60 C for 64 hours, the reaction mixture was worked up with isopropanol/dichloromethane. The organic solution was dried and concentrated under reduced pressure. The residue was chromatographed (gradient 0% to 8% methanol/7N NH3/ethyl acetate). The crude product was purified further by reverse phase liquid chromatography. MS ESI (+) m/z 452, 454 (M+1, Br pattern) detected; 1H NMR (400 MHz, DMSO-d6) delta 9.69 (s, 1H), 8.63 (d, 1H, J = 7 Hz), 8.52 (s, 1H), 8.10 (s, 1H), 7.94 (s, 1H), 7.82 (d, 1H, J = 3 Hz), 7.78 (dd, 1H, J = 3 Hz, 9 Hz), 7.59 (s, 1H), 7.16 (d, 1H, J = 9 Hz), 6.96 (dd, 1H, J = 2 Hz, 7 Hz), 6.63 (s, 1H), 2.19 (s, 3H).
 

Historical Records

Technical Information

Categories