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Chemical Structure| 936092-38-5 Chemical Structure| 936092-38-5

Structure of 936092-38-5

Chemical Structure| 936092-38-5

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Product Details of [ 936092-38-5 ]

CAS No. :936092-38-5
Formula : C17H23N5O
M.W : 313.40
SMILES Code : NC1=NC(NC2=CC=C(OCCN3CCCC3)C=C2)=NC=C1C

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Application In Synthesis of [ 936092-38-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 936092-38-5 ]

[ 936092-38-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 936092-87-4 ]
  • [ 936092-38-5 ]
  • N2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-5-methyl-N4-(7-methyl-1H-indol-4-yl)pyrimidine-2,4-diamine hydrochloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
15% [0246] A mixture of intermediate 38 (410 mg, 1.3 mmol), 4-bromo-7-methyl-lH-indole (275 mg, 1.3 mmol), Pd2(dba)3 (92 mg, 0.1 mmol), Xantphos (180 mg, 0.3 mmol) and cesium carbonate (1.3 g, 4 mmol) was suspended in dioxane (50 mL) and heated at reflux under the argon atmosphere for 20 h. The mixture was filtered and the filtrate concentrated in vacuo. The residue was purified by HPLC to afford the title compound (92 mg of HCl salt, 15%) as a white solid.[0247] 1H NMR (500 MHz, DMSO-d6): δ 1.88-1.90 (m, 2H), 1.93-2.02 (m, 2H), 2.21 (s, 3H), 2.55 (s, 3H), 3.06-3.10 (m, 2H), 3.51-3.54 (m, 4H), 4.26 (t, J= 4.9 Hz, 2H), 6.33-6.34 (m, IH), 6.61 (br d, 2H), 6.93-6.95 (m, 2H), 7.03 (d, J= 8.9 Hz, 2H), 7.34 (t, J= 2.8 Hz, IH), 7.85 (s, IH), 10.07 (s, IH), 10.33 (s, IH), 10.91 (br s, IH), 11.34 (s, IH), 12.15 (br s, H). MS (ES+): m/z 443 (M+H)+.
 

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