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Chemical Structure| 933752-44-4 Chemical Structure| 933752-44-4

Structure of 933752-44-4

Chemical Structure| 933752-44-4

5-Bromo-1,3-thiazole-2-carbaldehyde

CAS No.: 933752-44-4

4.5 *For Research Use Only !

Cat. No.: A133020 Purity: 98%

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Product Details of [ 933752-44-4 ]

CAS No. :933752-44-4
Formula : C4H2BrNOS
M.W : 192.03
SMILES Code : O=CC1=NC=C(Br)S1
MDL No. :MFCD09870032
InChI Key :DYDCPFNVIPHVKC-UHFFFAOYSA-N
Pubchem ID :26370427

Safety of [ 933752-44-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 933752-44-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 933752-44-4 ]

[ 933752-44-4 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 933752-44-4 ]
  • [ 911052-85-2 ]
YieldReaction ConditionsOperation in experiment
66% at 20℃; for 1.16667 h; 00188] To a solution of sodium borohydride (0.030 g, 0.781 mmol) in MeOH (2.0 mL) was added a solution of 5-bromothiazole-2-carbaldehyde (0.100 g, 0.521 mmol) in MeOH (1.00 mL) dropwise over a period of 5 min at room temperature. Upon the conclusion of this period, the reaction mixture was stirred at room temperature for 1 h. After this time, the solvent was removed in vacuo and the resulting residue was partitioned between EtOAc and water. The organic layer was separated and the aqueous phase was extracted with EtOAc. The combined organic layer was dried over anhydrous MgS04, filtered, and concentrated in vacuo to afford the title compound (0.067 g, 66percent yield) as a dark oil. LCMS, [M+H]+ = 195.9.
References: [1] Patent: WO2012/149236, 2012, A1, . Location in patent: Page/Page column 136.
[2] Patent: WO2004/46101, 2004, A2, . Location in patent: Page 31-32.
  • 2
  • [ 68-12-2 ]
  • [ 933752-44-4 ]
References: [1] Patent: WO2004/46101, 2004, A2, . Location in patent: Page 31-32.
 

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