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Chemical Structure| 932032-16-1 Chemical Structure| 932032-16-1

Structure of 932032-16-1

Chemical Structure| 932032-16-1

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Product Details of [ 932032-16-1 ]

CAS No. :932032-16-1
Formula : C6HNO5S
M.W : 199.14
SMILES Code : O=C(C1=CSC([N+]([O-])=O)=C12)OC2=O

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Application In Synthesis of [ 932032-16-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 932032-16-1 ]

[ 932032-16-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 253168-94-4 ]
  • [ 932032-16-1 ]
  • [ 1255908-80-5 ]
YieldReaction ConditionsOperation in experiment
Example 1 5-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1-nitro-5H-thiophene [3,4-c]pyrrole-4,6-diketone To a 250 ml of round-bottom flask equipped with an electromagnetic stirrer and a drying tube were added 1.99 g of compound 9, 2.73 g of compound 3a and 100 ml of THF. The mixture was stirred overnight at the room temperature. 1.944 g of CDI was added. The resultant mixture was refluxed in an oil-bath for 2 hours. The mixture was cooled to the room temperature in the open air. 200 ml of ethyl acetate and 150 ml of water were added. The mixture was extracted and separated. The organic layer was washed with 100 ml of 0.5N HCl, 100 ml of saturated NaCl, then dried over anhydrous MgSO4 and filtered. The solvent was evaporated. 3.541 g of a light yellow solid was given after purified with column chromatography. MS (m/z): 453 [M-1]+.
  • 2
  • [ 608141-42-0 ]
  • [ 932032-16-1 ]
  • [ 1255908-99-6 ]
YieldReaction ConditionsOperation in experiment
79% A mixture of 4-nitrothieno[3,4-c]furan-1,3-dione (5.5 g, 27.64 mmol), and (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine (7.54 g, 27.64 mmol) in THF (250 mL) was stirred at RT for 16 h.Then 1,1'-carbonyldiimidazol (CDI) (5.37 g, 33.1 mmol) was added and the reaction was heated to reflux for 3 h.The mixture was concentrated and purified on silica gel eluting with EA/PE from 30% to 50% to give (S)-5-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1-nitro-4H-thieno[3,4-c]pyrrole-4,6(5H)-dione (10.0 g, 79%) as a yellow solid.
 

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