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Chemical Structure| 927689-68-7 Chemical Structure| 927689-68-7

Structure of 927689-68-7

Chemical Structure| 927689-68-7

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Product Details of [ 927689-68-7 ]

CAS No. :927689-68-7
Formula : C16H14INO2
M.W : 379.19
SMILES Code : OC[C@H]1N=C(C2=CC=CC=C2)O[C@@H]1C3=CC=C(I)C=C3
MDL No. :MFCD10687188

Safety of [ 927689-68-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 927689-68-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 927689-68-7 ]

[ 927689-68-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 927689-68-7 ]
  • [ 927689-69-8 ]
YieldReaction ConditionsOperation in experiment
53% With diethylamino-sulfur trifluoride; In dichloromethane; at -78 - 20℃; 4-FIuoromethyl-5-(4-iodo-phenyl)-2-phenyl-4,5-dihydro-oxazoIe (7): A solution of 6 (21 g, 55.40 mmol) in methylenechloride (800 ml) was cooled to -78 °C and DAST (1 1.62 ml, 88.67 mmol) was added dropwise. After addition, the mixture was slowly warmed up to room temperature and stirred at room temperature overnight before quenched with 10 ml of water. The mixture then washed with water (500 ml), saturated sodium bicarbonate (500 ml) and concentrated. The crude product was triturated with methylenechloride (50 ml) and filtered. The filtrate was concentrated and purified by flash cliiOmatography (silica gel, 15percent EtOAc in hexane) to afford 7 as with solid (12.5 g, 53percent). 'NMR (300 MHz, CDC13): delta 8.02 ( d, J = 7.4 Hz, 2H), 7.72 ( d, J = 7.4 Hz, 2H), 7.56 (m, 1H), 7.52 (m, 2H), 7.1 1 (d, J = 5.4 Hz, 2H), 5.52 (d, J = 6.9 Hz, 1H), 4.75 (ddd, J = 3.8, 9.5, 28.2 Hz, 1H), 4.60 (ddd, J = 3.8, 9.5, 28.2 Hz, 1H), 4.36 (m, 1H); C16Hi3FINO, LCMS (EI) m/z: 381 (M+)
 

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