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Chemical Structure| 92534-73-1 Chemical Structure| 92534-73-1

Structure of 92534-73-1

Chemical Structure| 92534-73-1

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Product Details of [ 92534-73-1 ]

CAS No. :92534-73-1
Formula : C5H8N4O
M.W : 140.14
SMILES Code : O=C(C1=C(N)C=NN1C)N
MDL No. :MFCD00464001

Safety of [ 92534-73-1 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H317
Precautionary Statements:P280-P301+P310
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 92534-73-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 92534-73-1 ]

[ 92534-73-1 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 39067-29-3 ]
  • [ 92534-73-1 ]
  • [ 1161414-23-8 ]
YieldReaction ConditionsOperation in experiment
With pyridine; O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate; In chloroform; at 20℃; for 70h; Preparation of N-[5-(aminocarbonyl)-1-methyl-1H-pyrazol-4-yl]-2-(3-pyridinyl)-4-thiazolecarboxamide by amide coupling with HATU: 2-(3-Pyridyl)thiazole-4-carboxylic acid (82 mg, 0.4 mmol) and 4-amino-2-methyl-2H-pyrazole-3-carboxamide (56 mg, 0.4 mmol) are introduced into chloroform (3 ml) and pyridine (0.2 ml). Then HATU O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (228 mg) is added, and the mixture is stirred in a closed vessel at room temperature for 70 h. The precipitated solid is filtered off with suction, washed with ethyl acetate, water and again with ethyl acetate and dried in vacuo. Purification of the solid by HPLC results in Example 1.16 as a white foam.C14H12N6O2S, M=328.4, LC-MS (ZQ): Rt=0.72, m/z=329 [M+H]+. 1H-NMR (300 MHz, D6-DMSO): δ=3.99 (s, 3H), 7.58 (m, 1H), 7.85 (br. s., 2H), 7.93 (s, 1H), 8.36 (m, 1H), 8.53 (m, 1H), 8.70 (m, 1H), 9.24 (m, 1H), 10.7 (s, 1H).
 

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