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Chemical Structure| 92367-50-5 Chemical Structure| 92367-50-5

Structure of 92367-50-5

Chemical Structure| 92367-50-5

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Product Details of [ 92367-50-5 ]

CAS No. :92367-50-5
Formula : C11H13NO
M.W : 175.23
SMILES Code : CC1=C(CNC)OC2=CC=CC=C12
MDL No. :MFCD18453528

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Application In Synthesis of [ 92367-50-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 92367-50-5 ]

[ 92367-50-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 92367-50-5 ]
  • [ 167837-43-6 ]
  • [ 709652-70-0 ]
YieldReaction ConditionsOperation in experiment
54% EDC (231 mg, 1.2 mmol) was added to a solution of (E)-3- (6-AMINO-PYRIDIN-3- yl) acrylic acid (164 mg, 1.0 mmol), methyl- (3-methyl-benzofuran-2-ylmethyl) amine (193 mg, 1.1 mmol), HOBTNo.H2O (149 mg, 1.1 mmol) and DIPEA (525 PL, 3.0 mmol) in dry DMF (10 mL). After 18 hr of stirring, the mixture was diluted with water (60 mL) and extracted with EtOAc (2X20 mL). The oraganic layer was washed with brine (2 x 30 mL), dried and evaporated. Flash chromatography (silica 1-3% MEOH in CH2Cl2) of the residue furnished pure free base which was dissolved in CH2C12 (10 mL). After addition OF HCL (1.5 mL, 1M in ether), the solvents were evaporated, washed with ether and dried to afford the title compound (195 mg, 54%). 1H NMR (300 MHz, DMSO-d6) 8 8.36 (m, 3H), 7.50 (m, 3H), 7.25 (m, 3H), 7.02 (m, 1H), 4.98 and 4.79 (rotamers, 2s, 2H), 3.17 and 2.92 (rotamers, 2s, 3H), 2.26 (s, 3H). MS (ESI) nile 322 (M+H) +.
 

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