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Chemical Structure| 92059-86-4 Chemical Structure| 92059-86-4

Structure of 92059-86-4

Chemical Structure| 92059-86-4

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Product Details of [ 92059-86-4 ]

CAS No. :92059-86-4
Formula : C13H10BrCl
M.W : 281.58
SMILES Code : ClC1=CC(C2=CC=CC=C2)=CC=C1CBr
MDL No. :MFCD28965930

Safety of [ 92059-86-4 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H314
Precautionary Statements:P261-P280-P305+P351+P338-P310
Class:8
UN#:3261
Packing Group:

Application In Synthesis of [ 92059-86-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 92059-86-4 ]

[ 92059-86-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 201286-95-5 ]
  • [ 92059-86-4 ]
  • 1-(2-chloro-4-phenylbenzyl)-6-(methoxycarbonyl)-3-methyl-1H-indazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium hydride; Preparation Example 60-1 1-(2-Chloro-4-phenylbenzyl)-<strong>[201286-95-5]6-(methoxycarbonyl)-3-methyl-1H-indazole</strong> In the same manner as in Preparation Example 39-5, a crude product of the object compound (1.10 g) was obtained from <strong>[201286-95-5]6-(methoxycarbonyl)-3-methyl-1H-indazole</strong> (0.475 g), 60% sodium hydride (0.10 g) and 2-chloro-4-phenylbenzyl bromide (0.70 g).. The crude product was used in the next step without purification. 1H-NMR(CDCl3, delta ppm): 2.64(3H, s), 3.94(3H, s), 5.73(2H, s), 6.74(1H, d, J=8.1 Hz), 7.31(1H, dd, J=8.1 and 1.8 Hz), 7.33-7.38(1H, m), 7.42(2H, t, J=7.5 Hz), 7.50-7.53(2H, m), 7.64-7.67(2H, m), 7.74(1H, d, J=8.4 Hz), 7.82(1H, dd, J=8.4 and 1.3 Hz), 8.13(1H, s)
  • 2
  • [ 201286-95-5 ]
  • [ 92059-86-4 ]
  • 2-(2-chloro-4-phenylbenzyl)-6-(methoxycarbonyl)-3-methyl-2H-indazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In water; ethyl acetate; at 70℃; for 14h; Preparation Example 152-1 2-(2-Chloro-4-phenylbenzyl)-6-(methoxycarbonyl)-3-methyl-2H-indazole A mixture of <strong>[201286-95-5]6-(methoxycarbonyl)-3-methyl-1H-indazole</strong> (1.90 g), 2-chloro-4-phenylbenzyl bromide (3.37 g), potassium carbonate (2.76 g), ethyl acetate(10 ml) and water (5 ml) was stirred for 14 hr at 70 C. Hexane and water were added, and the precipitated solid was collected by filtration and washed with a mixed solvent of ethyl acetate and hexane (2/3).. This was dried under reduced pressure to give the objective compound (1.02 g). 1H-NMR (CDCl3, delta ppm): 2.61(3H, s), 3.96(3H, s), 5.77(2H, s), 6.66(1H, d, J=8.1 Hz), 7.33-7.39(2H, m), 7.43(2H, t, J=7.6 Hz), 7.51(2H, d, J=7.5 Hz), 7.62-7.66(2H, m), 7.69(1H, d, J=8.8 Hz), 8.49(1H, s)
 

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