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Chemical Structure| 920501-58-2 Chemical Structure| 920501-58-2

Structure of 920501-58-2

Chemical Structure| 920501-58-2

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Product Details of [ 920501-58-2 ]

CAS No. :920501-58-2
Formula : C16H25IN2Si
M.W : 400.38
SMILES Code : CC([Si](N1C=CC2=C(I)C=CN=C21)(C(C)C)C(C)C)C

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Application In Synthesis of [ 920501-58-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 920501-58-2 ]

[ 920501-58-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 319474-34-5 ]
  • [ 13154-24-0 ]
  • [ 920501-58-2 ]
YieldReaction ConditionsOperation in experiment
Example 4; Preparation of N-[(1S)-2-amino-1-benzylethyl]-6,7-dihydro-2H-2,3-diazabenzo[cd]azulene-8-carboxamide dihydrochloride [(Ic), (A= -CH=, X= -CH2-CH2-, Y= -CH=, R2= H, R1 = (1S)-2-amino-1-benzylethyl)]; Step 1. 4-iodo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine, [(XX) (R9= TIPS) ]; 1.8 g (7.4 mmol) of <strong>[319474-34-5]4-iodo-1H-pyrrolo[2,3-b]pyridine</strong> (X) were dissolved with 30 mL of dry tetrahydrofuran. The resulting solution was cooled to 0C and 8.2 ml of 1N solution in THF of sodium bis(trimethylsilyl)amide were added under stirring and in argon atmosphere. After 15 minutes in the same conditions 2 mL of trisopropylsilyl chloride (9.3 mmol) were added dropwise. The reaction mixture was stirred at 0C for 30 minutes and further 30 minutes at room temperature. The solvent was then removed in vacuo, the residue taken up with dichloromethane and icy water and the layers separated. The organic phase was dried over sodium sulfate and evaporated to dryness. The crude was chromatographed on a silica gel column (eluent: n-hexane) to afford the title compound (1.7 g 57 % yield) as an yellowish oil.
  • 2
  • [ 920501-58-2 ]
  • [ 640735-23-5 ]
 

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