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Chemical Structure| 919278-09-4 Chemical Structure| 919278-09-4

Structure of 919278-09-4

Chemical Structure| 919278-09-4

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Product Details of [ 919278-09-4 ]

CAS No. :919278-09-4
Formula : C13H11ClN4O
M.W : 274.71
SMILES Code : NC1=CC=C(OC2=C(N(C)C=C3)C3=NC=N2)C=C1Cl

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Application In Synthesis of [ 919278-09-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 919278-09-4 ]

[ 919278-09-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 25475-67-6 ]
  • [ 919278-09-4 ]
  • [ 7693-46-1 ]
  • N-{2-chloro-4-[(5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy]phenyl}-N'-isoquinolin-3-ylurea [ No CAS ]
YieldReaction ConditionsOperation in experiment
16% With pyridine; In ISOPROPYLAMIDE; at 90℃; for 18h; To a solution of <strong>[25475-67-6]3-aminoisoquinoline</strong> (210 mg, 1.5 mmol), EPO <DP n="223"/>pyridine (236 muL, 2.9 mmol) and 4-nitrophenyl chlorocarbonate (294 mg, 1.5 mmol) in N,N-dimethylacetamide (6 mL) was added 2-chloro-4- [ (5-methyl-5H-pyrrolo [3, 2-d] pyrimidin-4- yl) oxy]"aniline (200 mg, 0.73 mmol), and the mixture was stirred at 900C for 18 hr. The reaction mixture was diluted with water, and extracted with ethyl acetate (chil) . The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and filtrated. The filtrate was concentrated under reduced pressure, and the residue was purified by column chromatography (NH silica gel, ethyl acetate) and recrystallized from ethyl acetate-hexane to give the title compound (53 mg, 16percent) as a colorless solid.1H-NMR (DMSO-de, 300 MHz) delta 4.11 (3H, s) , 6.61 (IH, d, J = 3.0 Hz), 7.30 - 8.40 (1OH, m) , 9.19 (IH, -s) , 10.08 (IH, s) .
 

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