918523-66-7|5-Methyl-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine| Ambeed

Yield	Reaction Conditions	Operation in experiment
95%	With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 1 h;	Step 2-Preparation of 5-methyl-1H-pyrrolo[2,3-b]pyridine (15)To 5-Methyl-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine (14, 0.160 g, 0.55 mmol) in tetrahydrofuran (3.0 mL) was added tetra-n-butylammonium fluoride (0.145 g, 0.55 mmol). The reaction was stirred for 1 hour at room temperature. The reaction was poured into water and extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated and purified by silica gel column chromatography eluting with 3percent methanol in dichloromethane to provide light yellow solid (15, 0.07 g, 95percent). MS (ESI)[M+H⁺]⁺=133.2.
95%	With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 1 h;	To 5-Methyl-l -triisopropylsilanyl-lH-pyrrolo[2,3-b]pyridine (100, 0.16O g, 0.55 mmol) in tetrahydrofuran (3.0 mL) was added tetra-n-butylammonium fluoride (0.145 g, 0.55 mmol). The reaction was stirred for 1 hour at room temperature. The reaction was poured into water and extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated and purified by silica gel column chromatography eluting with 3percent methanol in dichloromethane to provide light yellow solid (101, 0.07 g, 95percent).

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5-Methyl-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine

CAS No.: 918523-66-7

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[ 918523-66-7 ] Synthesis Path-Upstream 1~1

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