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Chemical Structure| 917918-80-0 Chemical Structure| 917918-80-0

Structure of 917918-80-0

Chemical Structure| 917918-80-0

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Product Details of [ 917918-80-0 ]

CAS No. :917918-80-0
Formula : C8H8N2O2
M.W : 164.16
SMILES Code : O=C1C(NC=C2)=C2C(OC)=CN1
MDL No. :MFCD09907831

Safety of [ 917918-80-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 917918-80-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 917918-80-0 ]

[ 917918-80-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 917918-80-0 ]
  • [ 619331-35-0 ]
YieldReaction ConditionsOperation in experiment
27% E1 7-Bromo-4-methoxy-6-azaindole To a flask containing 7-hydroxy-4-methoxy-6-azaindole (0.200 g, 1.22 mmol) was added anisole (3 mL) and then POBr3 (1.57 g, 6.09 mmol). The system was purged with Ar and then it was heated at 160 C. (oil bath temperature) for 1 h. The reaction mixture was then allowed to cool to room temperature, quenched with 2M HBr (5 mL) and extracted with methyl t-butyl ether. The aqueous phase was separated and the pH was adjusted to 6-7, after which it was extracted with EtOAc. The resulting organic phase was dried (MgSO4) and evaporated to give a solid residue which was chromatographed (SiO2/5% MeOH-DCM) to afford the title compound (0.076 g, 27%) as a white solid: LCMS m/e 227 (M+H)+.
 

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