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Chemical Structure| 917251-86-6 Chemical Structure| 917251-86-6

Structure of 917251-86-6

Chemical Structure| 917251-86-6

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Product Details of [ 917251-86-6 ]

CAS No. :917251-86-6
Formula : C10H5BrF3N
M.W : 276.05
SMILES Code : FC(F)(F)C1=CC2=C(N=C1)C(Br)=CC=C2
MDL No. :MFCD15144568
InChI Key :AQBADHOMRVAOTB-UHFFFAOYSA-N
Pubchem ID :46941511

Safety of [ 917251-86-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of [ 917251-86-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 917251-86-6 ]

[ 917251-86-6 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 917251-85-5 ]
  • [ 81290-20-2 ]
  • [ 917251-86-6 ]
YieldReaction ConditionsOperation in experiment
A mixture of cuprous iodide (0.25 g) and potassium fluoride (0.077 g) was placed under a high vacuum and heated until the solid assumed a sight green color. The cooled solid mass was suspended in anhydrous N-methylpyrrolidinone (5 mL) and then treated with <strong>[917251-85-5]8-bromo-3-iodoquinoline</strong> (Step 1, 0.40 g), followed by trifluoromethyl-trimethylsilane (0.17 g). The resulting mixture was stirred at 50 C. for 18 hours. The mixture was then cooled to room temperature and poured into 15% aqueous NH4OH and then extracted with Et2O. The organic layer was washed with water and brine, dried over anhydrous Na2SO4, filtered and concentrated on a rotary evaporator. The crude product was purified by flash chromatography on silica gel using hexane/ethyl acetate to give 0.24 g of the desired product as a brown oil; MS (ES) m/z (relative intensity); 277 (M+H)+ (100).
  • 2
  • [ 917251-85-5 ]
  • [ 10112-11-5 ]
  • [ 917251-86-6 ]
 

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