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Chemical Structure| 914348-04-2 Chemical Structure| 914348-04-2

Structure of 914348-04-2

Chemical Structure| 914348-04-2

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Product Details of [ 914348-04-2 ]

CAS No. :914348-04-2
Formula : C11H14N2O2
M.W : 206.24
SMILES Code : O=C(NC1CNC1)OCC1=CC=CC=C1
MDL No. :MFCD07368913

Safety of [ 914348-04-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 914348-04-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 914348-04-2 ]

[ 914348-04-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 914348-04-2 ]
  • [ 1071017-49-6 ]
  • 3-bromo-N1-(7-pyridin-4-ylisoquinolin-5-yl)propane-1,2-diamine trihydrobromide [ No CAS ]
YieldReaction ConditionsOperation in experiment
53% Example 88: 3-Bromo-N*1*-(7-pyridin-4-yl-isoquinolin-5-yl)-propane-1 ,2-diamine; To a solution of 1-chloro-3-pyridin-4-yl-[2,6]naphthyridine (108 mg, 0.447 mmol) in 1-Methyl- pyrrolidin-2-one (1.5 ml_) is added azetidin-3-yl-carbamic acid benzyl ester (276 mg, 1.34 mmol). The reaction mixture is heated to 900C for 16 h, cooled to rt and diluted with ethyl acetate. The organic layer is washed with NaHCO3, brine, dried over MgSO4, filtered and concentrated. Addition of ethyl acetate affords a precipitated that is filtered off. The precipitate is dissolved in acetic acid and HBr 33% in acetic acid (1 ml_) is added at rt. The mixture is stirred 15 min. at rt. Diethyl ether is added to the reaction mixture and the formed precipitate filtered off and dried under vacuum to yield to the title compound as a orange solid (142.6 mg, 0.23 mmol, 53%, 3HBr salt). MS: (358.17 and 360.2.1 ) [M+1]+
 

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