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Type HazMat fee for 500 gram (Estimated)
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Chemical Structure| 90915-18-7 Chemical Structure| 90915-18-7

Structure of 90915-18-7

Chemical Structure| 90915-18-7

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Product Details of [ 90915-18-7 ]

CAS No. :90915-18-7
Formula : C10H10N2O2
M.W : 190.20
SMILES Code : O=C(C1=CC=C2N(C)C(C)=NC2=C1)O
MDL No. :MFCD01240945

Safety of [ 90915-18-7 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H315-H319-H335
Precautionary Statements:P233-P260-P261-P264-P270-P271-P280-P301+P310-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P330-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 90915-18-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 90915-18-7 ]

[ 90915-18-7 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 67-56-1 ]
  • [ 90915-18-7 ]
  • [ 256936-11-5 ]
YieldReaction ConditionsOperation in experiment
75% Heating / reflux A room temperature solution of 1, 2-dimethyl-1H-benzoimidazole-5-carboxylic acid (1.00 g, 5. 26 mmol) in MEOH (20 mL) is treated with H2SO4 (0.6 mL). The reaction mixture is then heated to reflux and allowed to stir overnight. Upon completion, the reaction is cooled to room temperature then quenched with saturated aqueous NAHC03 (100 mL) and extracted with EtOAc (3 X 100 mL). The combined organic layers are dried (MGS04), filtered and concentrated to give the sub-title compound (810 mg, 75percent) as a yellow oil. Rf0. 69 (85: 15 CH2CL2/MEOH). 1H NMR (300 MHz, CDC13) 6 2.61 (s, 3H), 3.72 (s, 3H), 3.92 (s, 3H), 7.27 (d, J= 8.5 Hz, 1H), 7. 98 (d, J = 8.2 HZ,, LH), 8. 35 (s, 1H). APCI MS 7N/Z 205 [CLLHL2N202 + H] +.
References: [1] Organic Letters, 2008, vol. 10, # 6, p. 1183 - 1186.
[2] Patent: WO2004/67529, 2004, A1, . Location in patent: Page 213 - 214.
 

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