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Chemical Structure| 908140-15-8 Chemical Structure| 908140-15-8

Structure of 908140-15-8

Chemical Structure| 908140-15-8

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Product Details of [ 908140-15-8 ]

CAS No. :908140-15-8
Formula : C11H18N2O3
M.W : 226.27
SMILES Code : OC1(C#N)CCN(C(OC(C)(C)C)=O)CC1
MDL No. :MFCD11845430

Safety of [ 908140-15-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 908140-15-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 908140-15-8 ]

[ 908140-15-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 908140-15-8 ]
  • [ 392331-66-7 ]
YieldReaction ConditionsOperation in experiment
59% Step 2. tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate To a suspension of lithium alminium hydride (84 mg, 2.2 mmol) in THF (5 mL), a solution of tert-butyl 4-cyano-4-hydroxypiperidine-1-carboxylate (200 mg, 0.88 mmol, step 1 of Example 22) in THF (1 mL) was added dropwise at 0 C. The mixture was stirred for 1 h at that temperature and Na2SO4.10H2O (400 mg) was added slowly, and the mixture was stirred for 5 h at room temperature. The mixture was filtered though a pad of Celite, washed with CH2Cl2 (20 mL*2), the filtrate was concentrated to give clear colorless oil. The residue was chromatographed on a column of silica gel eluding with CH2Cl2/MeOH/NH4OH (14:1:0.1) to give 120 mg (59%) of the title compound as white solid. 1H-NMR (CDCl3) delta: 3.98-3.75 (2H, m), 3.17 (2H, t, J=10.8 Hz), 2.56 (2H, s), 1.46 (9H, s), 1.60-1.25 (4H, m). Signals due to O and N were not observed.
 

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